R44DE031194
Project Grant
Overview
Grant Description
Next generation MEMS-VCSEL technology for ultra-low-cost dental and periodontal swept source optical coherence tomography imaging.
Awardee
Funding Goals
NIDCR EXTRAMURAL RESEARCH PROVIDES RESEARCH FUNDS TO SUPPORT BASIC, TRANSLATIONAL, AND CLINICAL RESEARCH IN DENTAL, ORAL, AND CRANIOFACIAL HEALTH AND DISEASE THROUGH GRANTS, COOPERATIVE AGREEMENTS, AND CONTRACTS THAT SUPPORT SCIENTISTS WORKING IN INSTITUTIONS THROUGHOUT THE UNITED STATES AND INTERNATIONALLY. EXTRAMURAL PROGRAMS PLAN, DEVELOP, AND MANAGE SCIENTIFIC PRIORITIES THROUGH PORTFOLIO ANALYSES AND CONSULTATION WITH STAKEHOLDERS, ENCOURAGING THE MOST PROMISING DISCOVERIES AND EMERGING TECHNOLOGIES FOR RAPID TRANSLATION TO CLINICAL APPLICATIONS. THE INTEGRATIVE BIOLOGY AND INFECTIOUS DISEASES PROGRAMS SUPPORTS BASIC AND TRANSLATIONAL RESEARCH PROGRAMS ON ORAL MICROBIOLOGY, SALIVARY BIOLOGY AND IMMUNOLOGY, ORAL AND SALIVARY GLAND CANCERS, NEUROSCIENCE OF OROFACIAL PAIN AND TEMPOROMANDIBULAR DISORDERS, MINERALIZED TISSUE PHYSIOLOGY, DENTAL BIOMATERIALS, AND TISSUE ENGINEERING AND REGENERATIVE MEDICINE. THE BRANCH AIMS TO ACCELERATE PROGRESS IN BASIC AND TRANSLATIONAL RESEARCH IN THESE AREAS, AND FURTHER STIMULATE THE DISCOVERY PIPELINE BASED ON CLINICAL NEEDS. THE TRANSLATIONAL GENOMICS RESEARCH PROGRAMS SUPPORTS BASIC AND TRANSLATIONAL RESEARCH IN GENETICS, GENOMICS, DEVELOPMENTAL BIOLOGY, AND DATA SCIENCE TOWARD THE GOAL OF IMPROVING DENTAL, ORAL, AND CRANIOFACIAL HEALTH. THE FOCUS IS ON DECIPHERING THE GENETIC, MOLECULAR, AND CELLULAR MECHANISMS UNDERLYING DENTAL, ORAL, AND CRANIOFACIAL DEVELOPMENT AND ANOMALIES. THE BEHAVIORAL AND SOCIAL SCIENCES RESEARCH PROGRAMS SUPPORTS BASIC AND APPLIED RESEARCH TO PROMOTE ORAL HEALTH, TO PREVENT ORAL DISEASES AND RELATED DISABILITIES, AND TO IMPROVE MANAGEMENT OF CRANIOFACIAL CONDITIONS, DISORDERS, AND INJURY. THE PROGRAM PRIORITIZES MECHANISTIC RESEARCH THAT CONTRIBUTES TO A CUMULATIVE SCIENCE OF BEHAVIOR CHANGE, TO MAXIMIZE THE RIGOR, RELEVANCE, AND DISSEMINATION OF EFFICACIOUS BEHAVIOR CHANGE INTERVENTIONS. THE CLINICAL RESEARCH PROGRAMS SUPPORTS PATIENT-ORIENTED, POPULATION, AND COMMUNITY BASED RESEARCH AIMED AT IMPROVING THE DENTAL, ORAL, AND CRANIOFACIAL HEALTH OF THE NATION. THE CENTER FOCUSES ON A VARIETY OF DISEASES AND CONDITIONS THROUGH CLINICAL TRIALS, EPIDEMIOLOGIC STUDIES, PRACTICE-BASED RESEARCH, THE HIV/AIDS AND ORAL HEALTH PROGRAM, AND STUDIES OF ORAL HEALTH DISPARITIES AND INEQUITIES IN ALL AREAS OF NIDCR PROGRAMMATIC INTEREST. THE PROGRAM ENCOURAGES INVESTIGATIONS THAT HAVE THE POTENTIAL TO TRANSLATE FINDINGS INTO EVIDENCE-BASED CLINICAL APPLICATIONS. THE RESEARCH TRAINING AND CAREER DEVELOPMENT EXTRAMURAL PROGRAMS SPAN THE CAREER STAGES OF SCIENTISTS, SUPPORTING RESEARCH TRAINING AND CAREER DEVELOPMENT FOR PHD AND DUAL DEGREE DDS/DMD-PHD STUDENTS, POSTDOCTORAL SCHOLARS, AND EARLY CAREER, MIDCAREER, AND ESTABLISHED INVESTIGATORS. THE PROGRAMS MANAGE SUPPORT FOR FELLOWSHIPS, RESEARCH TRAINING GRANTS, CAREER DEVELOPMENT AND CAREER TRANSITION AWARDS, NIH LOAN REPAYMENT AWARDS, AND DIVERSITY SUPPLEMENTS TO SUPPORT RESEARCH EXPERIENCES FOR HIGH SCHOOL STUDENTS THROUGH INVESTIGATORS. NIDCR PARTICIPATES IN THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) AND SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAMS. THE SBIR PROGRAM IS INTENDED TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.THE STTR PROGRAM IS INTENDED TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. EXTRAMURAL PROGRAMS ARE ACCOUNTABLE FOR THE EFFICIENT AND EFFECTIVE USE OF TAXPAYER FUNDS TO SUPPORT RESEARCH ON DENTAL, ORAL, AND CRANIOFACIAL DISEASES AND DISORDERS AND IMPROVING THE ORAL HEALTH OF ALL AMERICANS. EXTRAMURAL PROGRAMS SUPPORT RESEARCH AND RESEARCH TRAINING TO ESTABLISH THE FOUNDATION FOR SCIENTIFIC DISCOVERIES THAT INCLUDE TRANSPARENT AND RIGOROUS PLANNING, PRIORITY SETTING, CONTINUOUS AND CONSISTENT REVIEWS OF PROGRESS, AND FOCUS ON THE DEVELOPMENT OF A DIVERSE, HIGHLY SKILLED, AND NIMBLE WORKFORCE THAT CAN RAPIDLY RESPOND TO SCIENTIFIC BREAKTHROUGHS AND PUBLIC HEALTH CHALLENGES. EXTRAMURAL PROGRAMS ARE ACCOUNTABLE FOR THE EFFICIENT AND EFFECTIVE USE OF TAXPAYER FUNDS TO SUPPORT RESEARCH ON DENTAL, ORAL, AND CRANIOFACIAL DISEASES AND EMPLOY EVALUATION DOMAINS, FROM NEEDS ASSESSMENT AND STRATEGIC PLANNING TO IMPLEMENTATION AND PROCESS EVALUATION, PERFORMANCE MEASUREMENT, AND OUTCOMES AND IMPACT ANALYSIS TO EVALUATE STRATEGIC OBJECTIVES
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
California
United States
Geographic Scope
State-Wide
Related Opportunity
Analysis Notes
Amendment Since initial award the End Date has been extended from 08/31/23 to 09/13/23 and the total obligations have increased 631% from $275,001 to $2,011,275.
Praevium Research was awarded
Project Grant R44DE031194
worth $2,011,275
from the National Institute of Dental and Craniofacial Research in September 2022 with work to be completed primarily in California United States.
The grant
has a duration of 1 year and
was awarded through assistance program 93.121 Oral Diseases and Disorders Research.
The Project Grant was awarded through grant opportunity Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R43/R44 Clinical Trial Not Allowed).
SBIR Details
Research Type
SBIR Phase I
Title
Next generation MEMS-VCSEL technology for ultra-low-cost dental and periodontal swept source optical coherence tomography imaging
Abstract
This proposal aims to enable a new generation of high-speed, low-cost, wavelength-flexible swept source optical coherence tomography (SS-OCT) imaging device technology targeting applications in dental imaging and based on microelectromechanical systems vertical cavity surface emitting lasers (MEMS-VCSELs) and planar lightwave circuits (PLCs). MEMS-VCSELs provide an unmatched combination of high and variable axial scan rate, dynamic single mode operation enabling long imaging range, and the potential for low-cost volume manufacturing through wafer scale fabrication and testing. The proposed effort involves a collaboration between Praevium Research, which pioneered MEMS-VCSELs for SS-OCT, and the University of Washington (UW), a world leader in SS-OCT structural and angiographic imaging in dentistry. This work seeks both to advance dental imaging science through new imaging tools and promote commercialization in cost-sensitive dental markets.Praevium Research will develop new high axial scan rate MEMS-VCSEL swept sources near water absorption minima at 1700nm and 2200nm, to enable longer imaging range due to reduced scattering at longer wavelengths. Imaging at these wavelengths may be particularly important in improving the ability of OCT to noninvasively determine periodontal pocket depth. In addition, Praevium will combine emerging electrically pumped MEMS-eVCSELs at 1310nm with advanced PLC technology, replacing bulky and environmentally sensitive fiber networks commonly employed in SS-OCT by lithographically defined waveguide devices. This will allow a radically miniaturized low-cost and stable SS-OCT subsystem with MEMS-VCSEL, optical amplifier, wavelength monitoring, and MZI interferometers on a single chip in a compact butterfly package, overcoming long-standing cost barriers to SS-OCT in dentistry.UW collaborators will use various generations of high axial scan rate MEMS-VCSELs, starting at 1310nm and migrating to 1700nm and 2200nm as these latter sources are developed, to develop real-time wide field of view (FOV) whole mouth structural (OCT) and label-free angiographic (OCTA) periodontal imaging. Current methods for assessing periodontal disease rely on invasive probing, induce unnecessary pain and bleeding, and are error-prone due to inconsistent frequency and force of probing and due to the complexity of gingival thickness and appearance. The proposed SS-OCT technology, by contrast, has the potential to create qualitative and quantitative imaging of microstructure and vasculature in gingival tissue. This will enable a comprehensive periodontal imaging diagnostic suite which can assess periodontal attachment, alveolar bone quality and level, gingival inflammation, sub gingival calculus plaque and tissue biotype. Such a system can also provide an objective means to determine and evaluate the prognosis of periodontal, regenerative and restorative therapies, improve computer-aided design and machining (CAD/CAM) for dental restorative procedures and planning, and become a reliable tool for long term monitoring and maintenance in clinical practice for oral health.
Topic Code
NIDCR
Solicitation Number
PA19-022
Status
(Complete)
Last Modified 1/21/25
Period of Performance
9/16/22
Start Date
9/13/23
End Date
Funding Split
$2.0M
Federal Obligation
$0.0
Non-Federal Obligation
$2.0M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for R44DE031194
Transaction History
Modifications to R44DE031194
Additional Detail
Award ID FAIN
R44DE031194
SAI Number
R44DE031194-575231140
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Small Business
Awarding Office
75NP00 NIH NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
Funding Office
75NP00 NIH NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
Awardee UEI
UEN4RJGPDNR4
Awardee CAGE
4B7L1
Performance District
CA-90
Senators
Dianne Feinstein
Alejandro Padilla
Alejandro Padilla
Budget Funding
Federal Account | Budget Subfunction | Object Class | Total | Percentage |
---|---|---|---|---|
National Institute of Dental and Craniofacial Research, National Institutes of Health, Health and Human Services (075-0873) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,150,001 | 100% |
Modified: 1/21/25