93.121: Oral Diseases and Disorders Research
Alternate Name: Dental, Oral and Craniofacial Research.
Aug. 5, 2022
Aug. 5, 2022
To improve oral, dental and craniofacial health through performing and supporting basic, translational, and clinical research; conducting and funding research training and career development programs to ensure an adequate number of talented, well-prepared, and diverse investigators; coordinating and assisting relevant research and research-related activities among all sectors of the research community; and promoting the timely transfer of knowledge gained from research and its implications for health to the public, health professionals, researchers, and policy-makers. 1. The Behavioral and Social Sciences (BSS) Research Program supports basic and applied BSS research to promote oral health, to prevent oral diseases and related disabilities, and to improve management of craniofacial conditions, disorders and injury. 2. The Clinical and Practice-Based Research Program supports cross-sectional descriptive, case-control, prospective cohort and retrospective studies of dental, oral, and craniofacial diseases and disorders. The NIDCR-supported National Dental Practice-Based Research Network is a program in which national oral health studies are conducted in dental practices on topics of importance to practitioners and their patients. 3. The Clinical Trials Program supports improving oral health with high-quality evidence derived from well-executed Phase I, II, III, and IV clinical trials. 4. The Data Science, Computational Biology and Bioinformatics Program focuses on challenges in integrating and interpreting diverse and high-volume data to better understand dental, oral, and craniofacial conditions and their health consequences including the areas of bioinformatics, data science, computational biology and computational genomics, and systems biology approaches to dental, oral, and craniofacial research. 5. The Dental Materials and Biomaterials Program supports development of innovative approaches to restore tissue function by replacement and/or enhancement of dental, oral and craniofacial tissues compromised by trauma or disease. NIDCR encourages basic and translational extramural research in dental materials, medical devices, biosensors, imaging, dental implants, biocompatibility of dental materials, and biomaterials for craniofacial restoration and reconstruction. 6. The Developmental Biology and Genetics program supports basic and translational research to better understand the development of craniofacial structures from the early embryonic specification of the neural crest through the later development of teeth and craniofacial sutures. This program also supports research into the genetic and environmental contributions to craniofacial disorders, particularly their study in model organisms. 7. The Health Disparities Research Program supports studies that: provide a better understanding of the basis of oral health disparities and inequities; develop and test interventions tailored/targeted to underserved populations; seek to understand a broadened array of determinants of disparities/inequities in oral health status and care at multiple levels; take a holistic, social ecological, multi-level interventional approach designed to have a meaningful impact on oral health status and quality of life of vulnerable and underserved populations. 8. The HIV/AIDS and Oral Health Research Program supports extramural basic, translational and clinical research on HIV/AIDS to advance understanding of the underlying molecular, cellular, immunological and genetic mechanisms of HIV infection, the development of oral co-morbidities associated with HIV/AIDS, and the effects of HIV treatments on oral and dental tissues. 9. The Microbiology Program supports basic research examining the role of the oral microbiota (comprising bacteria, archaea, fungi and viruses) in dental health and disease as well as preclinical studies aimed at developing new prevention and treatment options for dental infections. Topics include examining the oral microbiota through studies in microbial ecology, physiology and genetics; polyomic technologies (genomics, metagenomics and systems biology); mechanisms of microbial virulence and pathogenesis; and classical prevention and treatment strategies for combating infectious disease. 10. The Mineralized Tissue Physiology Program supports basic and translational science research on craniofacial skeletal biology and pathobiology, and pharmacogenetics, and promotes interdisciplinary and multidisciplinary approaches to advance the understanding of normal and abnormal processes underlying oral, dental, and craniofacial diseases and disorders. 11. The Neuroscience of Orofacial Pain and Temporomandibular Disorders Program supports basic, translational, and clinical research on: orofacial pain and neuropathies, temporomandibular joint and muscle disorders, development of biomarkers for diagnostics and prognostics, and development of therapeutics. 12. The Oral and Salivary Cancer Biology Program supports basic and translational research to improve detection and treatment of cancers of the oral cavity, pharynx, and salivary glands. Basic research focuses on susceptibilities and mechanisms that influence tumor initiation, promotion, and progression. Translational research focuses on development of innovative biomarkers, novel diagnostic technologies, and appropriate human specimens to better characterize cancers and improve medical decision making and treatment response evaluation. 13. The NIDCR research training and career development programs span the career stages of scientists, supporting training for basic, clinical, behavioral, and other research related to the NIDCR mission. 14. The Salivary Biology and Immunology Program encourages basic and translational research that furthers our understanding of the biology of saliva and salivary gland, immunology of oral diseases, and oral manifestations of systemic and infectious diseases; develops new tools and technologies to address challenges in these areas, and explores pathways toward commercialization and therapeutics. 15. The Tissue Engineering and Regenerative Medicine Program supports basic and translational research on employing bioengineering- and stem cell biology- based approaches for the reconstruction, repair, and regeneration of dental, oral, and craniofacial (DOC) tissues damaged because of disease or injury. The goal of this program is to advance engineering of biocompatible DOC tissue constructs and their functional integration into the host tissue microenvironment, and to support efforts aimed at healing and regeneration of endogenous host tissues. 16. The Translational Genetics and Genomics Program supports research designed to identify the genetic and molecular mechanisms underlying dental, oral, and craniofacial diseases and health. 17. The Small Business Innovation Research (SBIR) program seeks to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. 18. The Small Business Technology Transfer (STTR)STTR program seeks to stimulate and foster scientific and technological innovation and foster technology transfer through cooperative research and development carried out between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development; and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.
Type of Assistance
B - Project Grants
Research Project Grants: Scientists at universities, colleges, medical and dental schools, hospitals, laboratories, and other public or private nonprofit and for-profit institutions. NRSA and career development awards: (1) Nonprofit domestic organizations may apply for institutional awards. (2) Individual candidates or applicants must arrange sponsorship by a public or nonprofit private institution having staff and facilities appropriate to the proposed research training program. (3) All awardees must be citizens, or non-citizen nationals, of the United States or have been admitted to the United States for permanent residence, except for K99/R00, F99/K00, and T90/R90 grants. (4) To be eligible, postdoctoral NRSA and career development awardees must have a professional or scientific degree (M.D., Ph.D., D.D.S., D.V.M., Sc.D., D.Eng., or equivalent domestic or foreign degree). Institutional applicants must be able to provide the staff and facilities suitable for the proposed research training. SBIR and STTR grants: Can be awarded only to domestic small business concerns that meet the following criteria: 1) Is organized for profit, with a place of business located in the United States, which operates primarily within the United States or which makes a significant contribution to the United States economy through payment of taxes or use of American products, materials or labor; 2) Is in the legal form of an individual proprietorship, partnership, limited liability company, corporation, joint venture, association, trust or cooperative, except where the form is a joint venture, there must be less than 50 percent participation by foreign business entities in the joint venture; 3) Be a concern which is more than 50% directly owned and controlled by one or more individuals (who are citizens or permanent resident aliens of the United States), other business concerns (each of which is more than 50% directly owned and controlled by individuals who are citizens or permanent resident aliens of the United States), or any combination of these; no single venture capital operating company, hedge fund, or private equity firm may own more than 50% of the concern, 4) Has, including its affiliates, not more than 500 employees, and 5) meets the other regulatory requirements found in 13 C.F.R. Part 121. For STTR awards, the small business must partner with a research institution in a cooperative research and development project . In both Phase I and Phase II for both SBIR and STTR, the research must be performed in the U.S. and its possessions. To be eligible for funding, all grant applications must be evaluated for scientific merit and program relevance by a scientific peer review group and the National Advisory Dental and Craniofacial Research Council.
Health professionals, graduate students, undergraduate students, health professional students, scientists, researchers, and any nonprofit or for-profit organization, company or institution engaged in biomedical research.