HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain: Acute Pain Clinical Trials Program (U01 Clinical Trial Required)

Background
The Eunice Kennedy Shriver National Institute of Child Health and Human Development and participating NIH Institutes and Centers invite applications to this U01 Cooperative Agreement funding opportunity to support innovative, multi-site, large-scale investigator-initiated clinical trials to advance the understanding, assessment, measurement, treatment, and prevention of acute pain in infants, children, and adolescents, including those with disabilities and/or experiencing health disparities. This NOFO is part of the NIH Helping to End Addiction Long-Term (HEAL) Initiative, a trans-agency effort to fund research to find scientific solutions to the national opioid public health crisis.

Grant Details
The purpose of this Notice of Funding Opportunity (NOFO) is to advance the understanding, assessment, measurement, treatment, and prevention of pain in infants, children, and adolescents. The program supports research with high priority primary outcomes focused on improving the assessment, management, and/or treatment of acute pain in pediatric patients through innovative, multi-site clinical trials.

The program also encourages studies on acute pain assessment and treatments that cross through the continuum of care settings and include a primary or secondary focus on health equity and social determinants of health. The program aims to support multi-site clinical trials that seek to establish or implement systematic and/or multimodal approaches for the diagnosis, assessment, and effective treatment of acute pain for pediatric patients across various care settings.

Eligibility Requirements
Higher Education Institutions such as public/state controlled institutions of higher education and private institutions of higher education are eligible to apply for this grant opportunity.

Period of Performance
The maximum project period is 5 years.

Grant Value
The NIH HEAL (Helping to End Addiction Long-Term) Initiative intends to commit an estimated total cost of $11,000,000 to fund up to 3 to 5 awards in FY 2024. Applicants may request a budget for direct costs up to $2,100,000 per year.