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Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

ID: PAR-25-442 • Type: Posted
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Description

Posted: June 17, 2025, 12:00 a.m. EDT
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes.
Posted: June 17, 2025, 12:00 a.m. EDT
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Posted: May 28, 2025, 12:00 a.m. EDT
Posted: May 28, 2025, 12:00 a.m. EDT

Overview

On 6/17/25 the National Institutes of Health posted grant opportunity PAR-25-442 for Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed). The grant will be issued under grant program 93.121 Oral Diseases and Disorders Research.

Timing

Posted Date
June 17, 2025, 12:00 a.m. EDT
Closing Date
Feb. 17, 2028, 12:00 a.m. EST Due in 899 Days
Last Updated
July 29, 2025, 8:13 a.m. EDT
Version
2
Archive Date
March 24, 2028

Eligibility

Eligible Applicants
Public housing authorities/Indian housing authorities
Small businesses
City or township governments
Special district governments
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Independent school districts
State governments
Private institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Public and State controlled institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Info
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Contacts

Contact
National Institutes of Health
Contact Email
Email Description
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Contact Phone
(301) 402-2541
Additional Information
https://grants.nih.gov/grants/guide/pa-files/PAR-25-442.html

Documents

Posted documents for PAR-25-442

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