UM1DA058230
Cooperative Agreement
Overview
Grant Description
Data Analysis Center for Somatic Mosaicism Across Human Tissues Network - Project Summary
The goal of the Somatic Mosaicism Across Human Tissues (SMAHT) Network is to better characterize the occurrence of mosaic variants in human tissues and to understand their role in the regulation of biological processes that impact health and disease.
The SMAHT Data Analysis Center (DAC) aims to collect and curate all data generated in the network, assess, develop, and apply state-of-the-art analytical pipelines, and produce a variant catalog and a data portal for the scientific community.
We have assembled a team of investigators, bioinformatics scientists, data curators, and software developers with a strong track record in mosaic variant analysis, long-read data analysis, data portal development, visualization, large-scale data management and computing, and development of secure and flexible cloud technologies.
In Aim 1, we will work with the network members to define data and metadata standards and ensure that high-quality data are generated, processed, and annotated uniformly and efficiently.
In Aim 2, we will perform benchmark studies for the current tools and technologies for identification of mosaic variants and lead an effort to define and implement analytical pipelines on a cloud platform. We will also develop new approaches as needed. We will ensure that a comprehensive set of mosaic variants of all types (single nucleotide variants, indels, copy number variants, translocations, complex rearrangements, transposable element insertions, microsatellite mutations, repeat expansions, etc.) are identified, using short- and long-read platforms, genome-wide and targeted assays, and bulk and single cell technologies.
In Aim 3, we will build a user-friendly and interactive data portal containing a variant catalog and featuring a read-level variant browser to enable the scientific community to fully utilize the network data. We will ensure that all methods and processes are documented for full reproducibility and that all tools and data are freely available to the community.
The goal of the Somatic Mosaicism Across Human Tissues (SMAHT) Network is to better characterize the occurrence of mosaic variants in human tissues and to understand their role in the regulation of biological processes that impact health and disease.
The SMAHT Data Analysis Center (DAC) aims to collect and curate all data generated in the network, assess, develop, and apply state-of-the-art analytical pipelines, and produce a variant catalog and a data portal for the scientific community.
We have assembled a team of investigators, bioinformatics scientists, data curators, and software developers with a strong track record in mosaic variant analysis, long-read data analysis, data portal development, visualization, large-scale data management and computing, and development of secure and flexible cloud technologies.
In Aim 1, we will work with the network members to define data and metadata standards and ensure that high-quality data are generated, processed, and annotated uniformly and efficiently.
In Aim 2, we will perform benchmark studies for the current tools and technologies for identification of mosaic variants and lead an effort to define and implement analytical pipelines on a cloud platform. We will also develop new approaches as needed. We will ensure that a comprehensive set of mosaic variants of all types (single nucleotide variants, indels, copy number variants, translocations, complex rearrangements, transposable element insertions, microsatellite mutations, repeat expansions, etc.) are identified, using short- and long-read platforms, genome-wide and targeted assays, and bulk and single cell technologies.
In Aim 3, we will build a user-friendly and interactive data portal containing a variant catalog and featuring a read-level variant browser to enable the scientific community to fully utilize the network data. We will ensure that all methods and processes are documented for full reproducibility and that all tools and data are freely available to the community.
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding Agency
Place of Performance
Boston,
Massachusetts
021156030
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 168% from $1,999,999 to $5,359,235.
President And Fellows Of Harvard College was awarded
Data Analysis Center for Somatic Mosaicism Across Human Tissues Network
Cooperative Agreement UM1DA058230
worth $5,359,235
from the National Institute of Allergy and Infectious Diseases in May 2023 with work to be completed primarily in Boston Massachusetts United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.310 Trans-NIH Research Support.
The Cooperative Agreement was awarded through grant opportunity Somatic Mosaicism across Human Tissues (SMaHT) Program: Data Analysis Center (UM1 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 2/20/26
Period of Performance
5/1/23
Start Date
4/30/28
End Date
Funding Split
$5.4M
Federal Obligation
$0.0
Non-Federal Obligation
$5.4M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for UM1DA058230
Transaction History
Modifications to UM1DA058230
Additional Detail
Award ID FAIN
UM1DA058230
SAI Number
UM1DA058230-992018335
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Private Institution Of Higher Education
Awarding Office
75N600 NIH National Insitute on Drug Abuse
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
JDLVAVGYJQ21
Awardee CAGE
3Q2L2
Performance District
MA-07
Senators
Edward Markey
Elizabeth Warren
Elizabeth Warren
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Office of the Director, National Institutes of Health, Health and Human Services (075-0846) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,999,999 | 100% |
Modified: 2/20/26