UH3OD035546
Cooperative Agreement
Overview
Grant Description
Enriching ECHO cohorts with high-risk pregnancies and children with health challenges (ENRICHING ECHO) - Project/Narrative.
The overarching goal of the ENRICHING ECHO with high-risk pregnancies and children with health challenges (ENRICHING ECHO) cohort is to advance ECHO research by investigating environmental exposures that are associated with suboptimal and positive health outcomes in children with and without physical, sensory and developmental challenges.
Investigating factors associated with the full range of outcomes in children will enable us to identify critical predictors and inflection points to promote positive health for a lifetime.
Our scientific premise is that prenatal and perinatal environmental exposures and modifiable personal factors (e.g., parenting style, social supports) impact the wellbeing of children with chronic health challenges resulting in definable outcomes of function, life satisfaction, and participation in community and family life.
Our hypothesis is that we can identify modifiable factors associated with better-than-expected positive health outcomes along the continuum of development that allow children with chronic health challenges, and, by extension, all children, to thrive.
The ENRICHING ECHO award will address this hypothesis via the following specific aims:
Aim 1: Award 301 will (A) recruit participants with high-risk pregnancies who are most likely to deliver children at risk for chronic health challenges; (B) collaborate with community stakeholders with physical limitations and sensory impairments to design engagement, retention, and dissemination strategies; (C) standardize early ECHO surveillance for chronic health challenges; (D) ensure the ECHO protocol is implemented with high fidelity.
Aim 2: Leveraging ECHO core data elements, we will (A) compare trajectories from birth to school-age of typically developing children and those with sensory-motor impairments, and with cognitive/behavioral challenges with positive health (child well-being) as the primary outcome.
We will (B) evaluate the effect of prenatal environmental exposures and (C) the moderating effects of child postnatal nutrition, sleep health and physical activity on the slopes of positive health trajectories from birth to school-age.
Aim 3: In the entire ECHO cohort (A) we will identify maternal pre- and peri-natal psychosocial and chemical exposures associated with postnatal outcomes (birthweight, prematurity, birth defects, early life health challenges, neurodevelopment) in high-risk and in uncomplicated pregnancies.
(B) We will test which pre-, peri- and post-natal factors best predict the primary outcome of child well-being (positive health) at school-age.
(C) Comparing children with and without a reported chronic health condition, we will examine whether parenting style and caregiver social support are modifiable exposures associated with better-than-expected positive health.
Aim 4: In a cohort of ECHO participants with second pregnancies, we will explore whether the peri-natal environmental exposures associated with positive child health in the older ECHO sibling are predictive of post-natal birth outcomes in the second ECHO pregnancy.
The overarching goal of the ENRICHING ECHO with high-risk pregnancies and children with health challenges (ENRICHING ECHO) cohort is to advance ECHO research by investigating environmental exposures that are associated with suboptimal and positive health outcomes in children with and without physical, sensory and developmental challenges.
Investigating factors associated with the full range of outcomes in children will enable us to identify critical predictors and inflection points to promote positive health for a lifetime.
Our scientific premise is that prenatal and perinatal environmental exposures and modifiable personal factors (e.g., parenting style, social supports) impact the wellbeing of children with chronic health challenges resulting in definable outcomes of function, life satisfaction, and participation in community and family life.
Our hypothesis is that we can identify modifiable factors associated with better-than-expected positive health outcomes along the continuum of development that allow children with chronic health challenges, and, by extension, all children, to thrive.
The ENRICHING ECHO award will address this hypothesis via the following specific aims:
Aim 1: Award 301 will (A) recruit participants with high-risk pregnancies who are most likely to deliver children at risk for chronic health challenges; (B) collaborate with community stakeholders with physical limitations and sensory impairments to design engagement, retention, and dissemination strategies; (C) standardize early ECHO surveillance for chronic health challenges; (D) ensure the ECHO protocol is implemented with high fidelity.
Aim 2: Leveraging ECHO core data elements, we will (A) compare trajectories from birth to school-age of typically developing children and those with sensory-motor impairments, and with cognitive/behavioral challenges with positive health (child well-being) as the primary outcome.
We will (B) evaluate the effect of prenatal environmental exposures and (C) the moderating effects of child postnatal nutrition, sleep health and physical activity on the slopes of positive health trajectories from birth to school-age.
Aim 3: In the entire ECHO cohort (A) we will identify maternal pre- and peri-natal psychosocial and chemical exposures associated with postnatal outcomes (birthweight, prematurity, birth defects, early life health challenges, neurodevelopment) in high-risk and in uncomplicated pregnancies.
(B) We will test which pre-, peri- and post-natal factors best predict the primary outcome of child well-being (positive health) at school-age.
(C) Comparing children with and without a reported chronic health condition, we will examine whether parenting style and caregiver social support are modifiable exposures associated with better-than-expected positive health.
Aim 4: In a cohort of ECHO participants with second pregnancies, we will explore whether the peri-natal environmental exposures associated with positive child health in the older ECHO sibling are predictive of post-natal birth outcomes in the second ECHO pregnancy.
Awardee
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding Agency
Place of Performance
Hackensack,
New Jersey
076011915
United States
Geographic Scope
Single Zip Code
HMH Hospitals Corporation was awarded
Enhancing Child Well-Being Through Environmental Exposures Study
Cooperative Agreement UH3OD035546
worth $5,019,949
from the National Institute of Allergy and Infectious Diseases in September 2023 with work to be completed primarily in Hackensack New Jersey United States.
The grant
has a duration of 6 years 8 months and
was awarded through assistance program 93.310 Trans-NIH Research Support.
The Cooperative Agreement was awarded through grant opportunity Open Competition: Environmental influences on Child Health Outcomes (ECHO) Pregnancy Cohort Study Sites. Clinical Trial Not Allowed (UG3/UH3).
Status
(Ongoing)
Last Modified 7/3/25
Period of Performance
9/1/23
Start Date
5/31/30
End Date
Funding Split
$5.0M
Federal Obligation
$0.0
Non-Federal Obligation
$5.0M
Total Obligated
Activity Timeline
Additional Detail
Award ID FAIN
UH3OD035546
SAI Number
UH3OD035546-620391492
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Nonprofit With 501(c)(3) IRS Status (Other Than An Institution Of Higher Education)
Awarding Office
75AGNA NIH AGGREGATE FINANCIAL ASSISTANCE DATA AWARDING OFFICE
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
LV8GL8MLU9A3
Awardee CAGE
37QX6
Performance District
NJ-05
Senators
Robert Menendez
Cory Booker
Cory Booker
Modified: 7/3/25