UH3HL154297

Community Intervention to Reduce Cardiovascular Disease in Chicago (CIRCL-Chicago) - 1. Project Summary/Abstract

Hypertension affects 1 in every 3 adults in the US and contributes to 410,000 deaths annually. Hypertension and its associated complications disproportionately affect minority populations living in urban areas. In Chicago, health status indicators show worsening disparities between black and white residents, with the highest rates of hypertension, heart disease, and stroke clustering in the predominantly black South and West Sides.

Kaiser Permanente demonstrated that a bundle of evidence-based interventions implemented within a large, integrated health system in Northern California significantly increased blood pressure control rates. However, it is unclear whether a health system-centered intervention can be adapted to other settings, particularly under-resourced urban communities.

Therefore, our overall goal is to support a community-centered design and adaptation of the Kaiser bundle. Our adaptation shifts the Kaiser bundle to be centered within churches within the South Side of Chicago, one of the most medically underserved communities in the United States.

The proposed interventions are the same as in the Kaiser bundle (e.g., registry/audit and feedback, simplified treatment regimens, accurate blood pressure measurement) but implementation of the components of the bundle will be adapted for delivery in the community. The intervention will be carried out by local community health workers and ministry facilitators, with health clinics and hospitals in the community as support, all connected through a common data platform.

Thus, our proposed project will identify the best strategies to support adoption, implementation with fidelity, and sustainability of the Kaiser bundle in the community setting. The proposed study will follow the Exploration, Preparation, Implementation and Sustainment (EPIS) process model and implementation is rigorously evaluated using a multimethod approach to the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) evaluation framework.

Our specific aims are:

AIM 1: Convene community stakeholders in order to adapt implementation strategies using the Dynamic Adaptation Process Model.

AIM 2: Design, implement, and evaluate pilot projects in order to optimize implementation strategies within our community.

AIM 3: Implement, test, and evaluate an adapted implementation strategy to control hypertension through faith-based organizations in the South Side of Chicago.

Our overall implementation is a hybrid Type 2 effectiveness-implementation design based within one primary community area (South Side Chicago) and in two settings (church and clinic). The overall study outcome is the public health impact metric (Reach * Effect Size of the Intervention).

AIM 4: Disseminate findings internally to community stakeholders and externally through creation of community implementation toolkits.

Northwestern University

NOT APPLICABLE

93.837 - Cardiovascular Diseases Research

National Heart Lung and Blood Institute (NHLBI) [HHS - NIH]

Chicago, Illinois 60611 United States

Single Zip Code

Disparities Elimination through Coordinated Interventions to Prevent and Control Heart and Lung Disease Risk (DECIPHeR) (UG3/UH3 Clinical Trial Optional) (RFA-HL-20-003)

Amendment Since initial award the total obligations have increased 238% from $1,173,836 to $3,968,134.