UG3TR004501
Cooperative Agreement
Overview
Grant Description
Integration and interoperability of complex data and tissues from the human brain - project summary:
Health information is siloed and often suffers from the sheer volume and the heterogeneous nature of complex datasets. This is in stark contrast to what a physician does when a patient is evaluated. Data from electronic health records, blood tests, imaging, electrical recordings, genomic studies, and neuropsychological measures are combined in the clinician's mind to find the best diagnosis and treatment plan.
Nowhere is this more challenging than for studies of the human brain. We have developed a one-of-a-kind human brain tissue bank where each brain sample is spatially linked to a comprehensive multimodal dataset using standardized tissue processing techniques using a home-grown software platform called INTUITION. Highly curated and integrated data are assembled from patients to help both in clinical care and provide a unique research platform for the human brain that is linked to fresh human brain tissue samples.
Many patients undergo complex, multistep brain surgeries to treat their seizures. Studies using these standardized tissue methods and INTUITION software have already led to important new discoveries including molecular (genomic, proteomic, metabolomic) biomarkers, imaging methods, brain network discovery, and therapeutic targets that would otherwise not have been identified.
The major goals for this collaborative innovation award are to adapt, modify, and expand INTUITION and a brain tissue collection educational program into a standardized, virtual tissue bank and federated data platform for dissemination through 3 CTSA hubs with teams at 5 collaborating institutions in the city of Chicago. The platform leverages common data elements and will use a team of experts to develop new ones.
As part of this ambitious project, we will optimize brain image visualization and EEG tools, work with a highly diverse patient population that spans the age spectrum (pediatric and adult), and develop user-friendly tools that will be sustainable because of their combined utility for clinical care and research. Given the extraordinary value of highly curated fresh human brain tissues and the fact that brain surgeries are becoming less invasive, it is important that we take full advantage of these priceless tissues as soon as possible.
We will develop a hands-on education program followed by web-based training modules for human brain tissue localization and processing in parallel with standardized data processing, storage, and upload methods for images and EEG studies at each of the 5 sites. This is especially important for rare brain disorders that require collaboration from many centers to create a standardized, virtual pool of tissue samples and associated data.
Health information is siloed and often suffers from the sheer volume and the heterogeneous nature of complex datasets. This is in stark contrast to what a physician does when a patient is evaluated. Data from electronic health records, blood tests, imaging, electrical recordings, genomic studies, and neuropsychological measures are combined in the clinician's mind to find the best diagnosis and treatment plan.
Nowhere is this more challenging than for studies of the human brain. We have developed a one-of-a-kind human brain tissue bank where each brain sample is spatially linked to a comprehensive multimodal dataset using standardized tissue processing techniques using a home-grown software platform called INTUITION. Highly curated and integrated data are assembled from patients to help both in clinical care and provide a unique research platform for the human brain that is linked to fresh human brain tissue samples.
Many patients undergo complex, multistep brain surgeries to treat their seizures. Studies using these standardized tissue methods and INTUITION software have already led to important new discoveries including molecular (genomic, proteomic, metabolomic) biomarkers, imaging methods, brain network discovery, and therapeutic targets that would otherwise not have been identified.
The major goals for this collaborative innovation award are to adapt, modify, and expand INTUITION and a brain tissue collection educational program into a standardized, virtual tissue bank and federated data platform for dissemination through 3 CTSA hubs with teams at 5 collaborating institutions in the city of Chicago. The platform leverages common data elements and will use a team of experts to develop new ones.
As part of this ambitious project, we will optimize brain image visualization and EEG tools, work with a highly diverse patient population that spans the age spectrum (pediatric and adult), and develop user-friendly tools that will be sustainable because of their combined utility for clinical care and research. Given the extraordinary value of highly curated fresh human brain tissues and the fact that brain surgeries are becoming less invasive, it is important that we take full advantage of these priceless tissues as soon as possible.
We will develop a hands-on education program followed by web-based training modules for human brain tissue localization and processing in parallel with standardized data processing, storage, and upload methods for images and EEG studies at each of the 5 sites. This is especially important for rare brain disorders that require collaboration from many centers to create a standardized, virtual pool of tissue samples and associated data.
Awardee
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Chicago,
Illinois
60612
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 193% from $1,067,958 to $3,131,401.
University Of Illinois was awarded
Human Brain Tissue Integration and Interoperability Grant
Cooperative Agreement UG3TR004501
worth $3,131,401
from National Center for Advancing Translational Sciences in September 2023 with work to be completed primarily in Chicago Illinois United States.
The grant
has a duration of 2 years 10 months and
was awarded through assistance program 93.350 National Center for Advancing Translational Sciences.
The Cooperative Agreement was awarded through grant opportunity Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (UG3/UH3 Clinical Trial Optional).
Status
(Ongoing)
Last Modified 8/6/25
Period of Performance
9/20/23
Start Date
7/31/26
End Date
Funding Split
$3.1M
Federal Obligation
$0.0
Non-Federal Obligation
$3.1M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for UG3TR004501
Transaction History
Modifications to UG3TR004501
Additional Detail
Award ID FAIN
UG3TR004501
SAI Number
UG3TR004501-279062161
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NR00 NIH National Center for Advancing Translational Sciences
Funding Office
75NR00 NIH National Center for Advancing Translational Sciences
Awardee UEI
W8XEAJDKMXH3
Awardee CAGE
1YGW1
Performance District
IL-07
Senators
Richard Durbin
Tammy Duckworth
Tammy Duckworth
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Center for Advancing Translational Sciences, National Institutes of Health, Health and Human Services (075-0875) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,067,958 | 100% |
Modified: 8/6/25