UG3HL162967
Cooperative Agreement
Overview
Grant Description
Colorado Nurse Family Heart Trial for the Enrich Program - Project Summary
Cardiovascular disease (CVD) is the leading cause of death in the United States, with disproportionately greater impact on racial/ethnic minorities and lower-income individuals. Risk for CVD begins very early in life as adverse exposures during critical periods (fetal development, infancy, and reproductive years) shift the health trajectory toward overt disease. Thus, efforts to promote and maintain cardiovascular health (CVH) from pregnancy onward are crucial to reducing the intergenerational burden of CVD.
In response to the Early Intervention to Promote Cardiovascular Health of Mothers and Children Request for Applications (ENRICH RFA), we propose to leverage two widely-available interventions to promote CVH in diverse, under-resourced pregnant women and offspring: Nurse Family Partnership (NFP) and the National Diabetes Prevention Program (NDPP).
NFP is a home visiting program in which nurses support first-time, under-resourced mothers from pregnancy to 24 months postpartum to improve prenatal outcomes, child safety and developmental outcomes, and economic self-sufficiency. NFP is available at over 260 organizations nationwide, including our Denver Health partners who have delivered it to over 2400 urban, under-resourced women since 2000. While NFP addresses some putative causes of compromised maternal and child health, CVH has not been comprehensively addressed nor evaluated.
Thus, we propose to enhance NFP with CVH-focused programming adapted from the NDPP, a yearlong, evidence-based lifestyle intervention that promotes healthy eating and activity to reduce weight, dysglycemia, and other CVD risks. We have delivered the NDPP to over 1600 diverse, under-resourced adults at Denver Health since 2013, including over 340 young women.
By leveraging the unique strengths of NFP (home delivery model, professional nursing support, impact on social determinants of health [SDOH]) with those of NDPP (evidence-based content for CVH promotion), a combined intervention (NFP-HEART) rigorously evaluated in the ENRICH program has great potential to improve CVH outcomes in under-resourced populations.
Our Colorado Nurse Family Heart Trial will evaluate NFP-HEART versus usual care among 600 nulliparous women (and their offspring) recruited in early pregnancy from 10 clinics in a safety-net, urban healthcare system. NFP-HEART will promote intergenerational CVH with programming delivered from 20 weeks gestation to 24 months postpartum by home visiting nurses.
Our specific aims are:
1) Develop the local NFP-HEART and common ENRICH protocols, and conduct pilot studies to confirm feasibility and acceptability.
2) Evaluate the effect of NFP-HEART on maternal and offspring CVH metrics.
3) Assess the degree to which SDOH modify the effect of the NFP-HEART intervention on maternal and offspring CVH outcomes.
4) Examine the implementation of the NFP-HEART intervention and potential for sustainability using a mixed-methods approach.
Cardiovascular disease (CVD) is the leading cause of death in the United States, with disproportionately greater impact on racial/ethnic minorities and lower-income individuals. Risk for CVD begins very early in life as adverse exposures during critical periods (fetal development, infancy, and reproductive years) shift the health trajectory toward overt disease. Thus, efforts to promote and maintain cardiovascular health (CVH) from pregnancy onward are crucial to reducing the intergenerational burden of CVD.
In response to the Early Intervention to Promote Cardiovascular Health of Mothers and Children Request for Applications (ENRICH RFA), we propose to leverage two widely-available interventions to promote CVH in diverse, under-resourced pregnant women and offspring: Nurse Family Partnership (NFP) and the National Diabetes Prevention Program (NDPP).
NFP is a home visiting program in which nurses support first-time, under-resourced mothers from pregnancy to 24 months postpartum to improve prenatal outcomes, child safety and developmental outcomes, and economic self-sufficiency. NFP is available at over 260 organizations nationwide, including our Denver Health partners who have delivered it to over 2400 urban, under-resourced women since 2000. While NFP addresses some putative causes of compromised maternal and child health, CVH has not been comprehensively addressed nor evaluated.
Thus, we propose to enhance NFP with CVH-focused programming adapted from the NDPP, a yearlong, evidence-based lifestyle intervention that promotes healthy eating and activity to reduce weight, dysglycemia, and other CVD risks. We have delivered the NDPP to over 1600 diverse, under-resourced adults at Denver Health since 2013, including over 340 young women.
By leveraging the unique strengths of NFP (home delivery model, professional nursing support, impact on social determinants of health [SDOH]) with those of NDPP (evidence-based content for CVH promotion), a combined intervention (NFP-HEART) rigorously evaluated in the ENRICH program has great potential to improve CVH outcomes in under-resourced populations.
Our Colorado Nurse Family Heart Trial will evaluate NFP-HEART versus usual care among 600 nulliparous women (and their offspring) recruited in early pregnancy from 10 clinics in a safety-net, urban healthcare system. NFP-HEART will promote intergenerational CVH with programming delivered from 20 weeks gestation to 24 months postpartum by home visiting nurses.
Our specific aims are:
1) Develop the local NFP-HEART and common ENRICH protocols, and conduct pilot studies to confirm feasibility and acceptability.
2) Evaluate the effect of NFP-HEART on maternal and offspring CVH metrics.
3) Assess the degree to which SDOH modify the effect of the NFP-HEART intervention on maternal and offspring CVH outcomes.
4) Examine the implementation of the NFP-HEART intervention and potential for sustainability using a mixed-methods approach.
Funding Goals
TO FOSTER HEART AND VASCULAR RESEARCH IN THE BASIC, TRANSLATIONAL, CLINICAL AND POPULATION SCIENCES, AND TO FOSTER TRAINING TO BUILD TALENTED YOUNG INVESTIGATORS IN THESE AREAS, FUNDED THROUGH COMPETITIVE RESEARCH TRAINING GRANTS. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, USE SMALL BUSINESS TO MEET FEDERAL RESEARCH AND DEVELOPMENT NEEDS, FOSTER AND ENCOURAGE PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY SOCIALLY AND ECONOMICALLY DISADVANTAGED PERSONS, AND INCREASE PRIVATE-SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, FOSTER TECHNOLOGY TRANSFER THROUGH COOPERATIVE R&D BETWEEN SMALL BUSINESSES AND RESEARCH INSTITUTIONS, AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL R&D.
Grant Program (CFDA)
Awarding Agency
Place of Performance
Colorado
United States
Geographic Scope
State-Wide
Related Opportunity
Analysis Notes
Amendment Since initial award the End Date has been extended from 04/30/24 to 06/30/24 and the total obligations have increased 2423% from $43,750 to $1,103,621.
The Regents Of The Univ. Of Colorado was awarded
Colorado Nurse Family Heart Trial for the ENRICH program
Cooperative Agreement UG3HL162967
worth $1,103,621
from the National Institute of Allergy and Infectious Diseases in May 2022 with work to be completed primarily in Colorado United States.
The grant
has a duration of 2 years 1 months and
was awarded through assistance program 93.310 Trans-NIH Research Support.
The Cooperative Agreement was awarded through grant opportunity Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) Multisite Clinical Centers (Collaborative UG3/UH3 Clinical Trial Required).
Status
(Complete)
Last Modified 12/5/24
Period of Performance
5/5/22
Start Date
6/30/24
End Date
Funding Split
$1.1M
Federal Obligation
$0.0
Non-Federal Obligation
$1.1M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for UG3HL162967
Transaction History
Modifications to UG3HL162967
Additional Detail
Award ID FAIN
UG3HL162967
SAI Number
UG3HL162967-303592176
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NH00 NIH NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
MW8JHK6ZYEX8
Awardee CAGE
0P6C1
Performance District
CO-90
Senators
Michael Bennet
John Hickenlooper
John Hickenlooper
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Heart, Lung, and Blood Institute, National Institutes of Health, Health and Human Services (075-0872) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,158,033 | 82% |
| National Institute on Minority Health and Health Disparities, National Institutes of Health, Health and Human Services (075-0897) | Health research and training | Grants, subsidies, and contributions (41.0) | $125,000 | 9% |
| Office of the Director, National Institutes of Health, Health and Human Services (075-0846) | Health research and training | Grants, subsidies, and contributions (41.0) | $62,500 | 4% |
| National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Health and Human Services (075-0884) | Health research and training | Grants, subsidies, and contributions (41.0) | $62,500 | 4% |
Modified: 12/5/24