UG1HD107691
Cooperative Agreement
Overview
Grant Description
Clinical Center for NIH's Nutrition for Precision Health: The All of Us New England Research Collaborative - Project Summary
The All of Us New England Clinical Center (AOU-NE-CC) is a collaboration of New England-based research teams with the necessary expertise and resources in nutrition and clinical translational science to implement successfully all 3 modules of the NIH Common Fund's Nutrition for Precision Health (NPH) Clinical Center Program.
The Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (Tufts-HNRCA) and Massachusetts General Hospital (MGH) will lead the AOU-NE-CC and partner with All of Us New England to ensure the diversity of participants and scientific rigor required to identify inter-individual variability of response to dietary patterns.
The AOU-NE-CC is committed to All of Us core values and has implemented best practices of team science throughout its development. The AOU-NE-CC will serve as a key partner in the development of a rigorous NPH common protocol and examine habitual dietary intake (Module 1), measure physiological responses to a mixed-meal challenge (Modules 1-3), and identify responses to 3 intervention diets in both free-living (Module 2) and domiciled (Module 3) controlled feeding conditions.
Coupled with standard All of Us data, the physiological responses collected through these modules will be used to develop predictive algorithms that inform precision nutrition approaches for long-term health.
To attain maximum metabolic and microbiome response variability, we propose the following 14-day isocaloric diets for Modules 2 and 3, separated by 4-week washout periods: (1) a high-adherence Dietary Approaches to Stop Hypertension (DASH) diet; (2) a low-adherence DASH diet; and (3) a ketogenic diet.
We also propose the use of the thoroughly tested mixed-meal challenge PhenFlex, which can be standardized across clinical centers to provide a multisystem assessment of metabolic flexibility.
With its outstanding core facilities, including metabolic kitchens and domiciled feeding and nursing centers, as well as a rich legacy of conducting rigorous feeding studies, the AOU-NE-CC is uniquely skilled and positioned to serve as a clinical center for the NPH.
Additional strengths of the AOU-NE-CC include extensive experience in recruiting clinical populations and biobanking, engaging volunteers through community outreach, active participation in global precision nutrition initiatives, and an outstanding track record of productive multisite collaborations in nutrition, omics, and precision health.
Importantly, the Tufts-HNRCA and MGH teams are closely aligned with the All of Us New England team and its record of high participant recruitment and retention and its diverse cohort, which will support the NPH consortium goals.
By partnering with NPH and All of Us in this novel modular discovery science study, the AOU-NE-CC and its experienced, forward-thinking, highly collaborative team will contribute to the development of precision nutrition approaches that support optimal health across the adult lifespan.
The All of Us New England Clinical Center (AOU-NE-CC) is a collaboration of New England-based research teams with the necessary expertise and resources in nutrition and clinical translational science to implement successfully all 3 modules of the NIH Common Fund's Nutrition for Precision Health (NPH) Clinical Center Program.
The Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (Tufts-HNRCA) and Massachusetts General Hospital (MGH) will lead the AOU-NE-CC and partner with All of Us New England to ensure the diversity of participants and scientific rigor required to identify inter-individual variability of response to dietary patterns.
The AOU-NE-CC is committed to All of Us core values and has implemented best practices of team science throughout its development. The AOU-NE-CC will serve as a key partner in the development of a rigorous NPH common protocol and examine habitual dietary intake (Module 1), measure physiological responses to a mixed-meal challenge (Modules 1-3), and identify responses to 3 intervention diets in both free-living (Module 2) and domiciled (Module 3) controlled feeding conditions.
Coupled with standard All of Us data, the physiological responses collected through these modules will be used to develop predictive algorithms that inform precision nutrition approaches for long-term health.
To attain maximum metabolic and microbiome response variability, we propose the following 14-day isocaloric diets for Modules 2 and 3, separated by 4-week washout periods: (1) a high-adherence Dietary Approaches to Stop Hypertension (DASH) diet; (2) a low-adherence DASH diet; and (3) a ketogenic diet.
We also propose the use of the thoroughly tested mixed-meal challenge PhenFlex, which can be standardized across clinical centers to provide a multisystem assessment of metabolic flexibility.
With its outstanding core facilities, including metabolic kitchens and domiciled feeding and nursing centers, as well as a rich legacy of conducting rigorous feeding studies, the AOU-NE-CC is uniquely skilled and positioned to serve as a clinical center for the NPH.
Additional strengths of the AOU-NE-CC include extensive experience in recruiting clinical populations and biobanking, engaging volunteers through community outreach, active participation in global precision nutrition initiatives, and an outstanding track record of productive multisite collaborations in nutrition, omics, and precision health.
Importantly, the Tufts-HNRCA and MGH teams are closely aligned with the All of Us New England team and its record of high participant recruitment and retention and its diverse cohort, which will support the NPH consortium goals.
By partnering with NPH and All of Us in this novel modular discovery science study, the AOU-NE-CC and its experienced, forward-thinking, highly collaborative team will contribute to the development of precision nutrition approaches that support optimal health across the adult lifespan.
Awardee
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Place of Performance
Boston,
Massachusetts
021111524
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 1223% from $553,946 to $7,327,710.
Trustees Of Tufts College was awarded
Precision Nutrition for Health: AOU-NE-CC's New England Research
Cooperative Agreement UG1HD107691
worth $7,327,710
from the National Institute of Allergy and Infectious Diseases in December 2021 with work to be completed primarily in Boston Massachusetts United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.310 Trans-NIH Research Support.
The Cooperative Agreement was awarded through grant opportunity Nutrition for Precision Health, powered by the All of Us Research Program: Clinical Centers (UG1 Clinical Trial Required).
Status
(Ongoing)
Last Modified 12/17/24
Period of Performance
12/10/21
Start Date
11/30/26
End Date
Funding Split
$7.3M
Federal Obligation
$0.0
Non-Federal Obligation
$7.3M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for UG1HD107691
Transaction History
Modifications to UG1HD107691
Additional Detail
Award ID FAIN
UG1HD107691
SAI Number
UG1HD107691-897731445
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Private Institution Of Higher Education
Awarding Office
75NT00 NIH EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
C1F5LNUF7W86
Awardee CAGE
3G627
Performance District
MA-07
Senators
Edward Markey
Elizabeth Warren
Elizabeth Warren
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Office of the Director, National Institutes of Health, Health and Human Services (075-0846) | Health research and training | Grants, subsidies, and contributions (41.0) | $2,452,811 | 100% |
Modified: 12/17/24