UG1HD107688
Cooperative Agreement
Overview
Grant Description
UAB Precision Nutrition Clinical Center - Abstract
The reasons for individual variability in the physiologic response to dietary patterns are not well understood but hamper efforts to provide optimum diets to our population. There is an urgent need to understand the complex interaction of demographic, genetic, metabolic, behavioral, psychosocial, and environmental factors that affect the responses to dietary patterns in order to prevent and treat nutrition-related chronic diseases. The field of "precision nutrition" holds great promise for elucidating these interactions to eventually predict the optimal diet for an individual or groups of individuals.
The overall objective of this application is to demonstrate that the University of Alabama at Birmingham (UAB) is uniquely positioned to join the consortium as a Nutrition for Precision Health Clinical Center (RFA-RM-21-005). The study team will collect a wide range of physiological and metabolic data from individuals in response to free-living (Module 1) and controlled diets (Modules 2 & 3), that will be used in analyses to determine potential predictors of response to diet. Sophisticated data methods (artificial intelligence, machine learning, mathematical modeling) will then be employed by the study group to identify the comprehensive phenotypes needed for individualizing diet prescriptions.
We aim to accomplish the following three specific aims:
Specific Aim 1 (Module 1): Conduct an observational study of 2000 free-living individuals consuming their usual diet for 14 days. The physiologic responses to a standardized test meal challenge will be assessed while they are consuming their usual diet.
Specific Aim 2 (Module 2): Conduct a free-living controlled feeding study in 400 subjects fed three isocaloric diets varying in macronutrient composition at maintenance energy requirements. Diets are designed to elicit a wide range of responses among participants. The physiologic responses to standardized test meals and diet-specific meals will be measured at the end of each 14-day diet period. We will also collect measures of 24-HR glucose, 24-HR blood pressure, 24-HR physical activity, cardiorespiratory fitness, and sleep during each diet period.
Specific Aim 3 (Module 3): Conduct a domiciled controlled feeding study in 150 subjects of three isocaloric diets (same diets as in Aim #1) fed at maintenance energy requirements. In addition to Module 2 outcomes, assessments including room calorimetry, doubly labelled water, cardiorespiratory fitness, and muscle and fat biopsies will be completed in Module 3 participants while they are domiciled in cottages at the Lakeshore Foundation Campus near UAB.
Achieving these aims will create a database that allows sophisticated data analysis (e.g., AI, machine learning) to develop algorithms to match people to optimum diets. UAB, with access to >16,000 All of Us participants in Birmingham, outstanding facilities for conducting diet interventions, and an outstanding research team, can be a valued member of the Nutrition for Precision Health Consortium.
The reasons for individual variability in the physiologic response to dietary patterns are not well understood but hamper efforts to provide optimum diets to our population. There is an urgent need to understand the complex interaction of demographic, genetic, metabolic, behavioral, psychosocial, and environmental factors that affect the responses to dietary patterns in order to prevent and treat nutrition-related chronic diseases. The field of "precision nutrition" holds great promise for elucidating these interactions to eventually predict the optimal diet for an individual or groups of individuals.
The overall objective of this application is to demonstrate that the University of Alabama at Birmingham (UAB) is uniquely positioned to join the consortium as a Nutrition for Precision Health Clinical Center (RFA-RM-21-005). The study team will collect a wide range of physiological and metabolic data from individuals in response to free-living (Module 1) and controlled diets (Modules 2 & 3), that will be used in analyses to determine potential predictors of response to diet. Sophisticated data methods (artificial intelligence, machine learning, mathematical modeling) will then be employed by the study group to identify the comprehensive phenotypes needed for individualizing diet prescriptions.
We aim to accomplish the following three specific aims:
Specific Aim 1 (Module 1): Conduct an observational study of 2000 free-living individuals consuming their usual diet for 14 days. The physiologic responses to a standardized test meal challenge will be assessed while they are consuming their usual diet.
Specific Aim 2 (Module 2): Conduct a free-living controlled feeding study in 400 subjects fed three isocaloric diets varying in macronutrient composition at maintenance energy requirements. Diets are designed to elicit a wide range of responses among participants. The physiologic responses to standardized test meals and diet-specific meals will be measured at the end of each 14-day diet period. We will also collect measures of 24-HR glucose, 24-HR blood pressure, 24-HR physical activity, cardiorespiratory fitness, and sleep during each diet period.
Specific Aim 3 (Module 3): Conduct a domiciled controlled feeding study in 150 subjects of three isocaloric diets (same diets as in Aim #1) fed at maintenance energy requirements. In addition to Module 2 outcomes, assessments including room calorimetry, doubly labelled water, cardiorespiratory fitness, and muscle and fat biopsies will be completed in Module 3 participants while they are domiciled in cottages at the Lakeshore Foundation Campus near UAB.
Achieving these aims will create a database that allows sophisticated data analysis (e.g., AI, machine learning) to develop algorithms to match people to optimum diets. UAB, with access to >16,000 All of Us participants in Birmingham, outstanding facilities for conducting diet interventions, and an outstanding research team, can be a valued member of the Nutrition for Precision Health Consortium.
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Place of Performance
Alabama
United States
Geographic Scope
State-Wide
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 1460% from $562,601 to $8,773,942.
University Of Alabama At Birmingham was awarded
UAB Precision Nutrition Clinical Center
Cooperative Agreement UG1HD107688
worth $8,773,942
from the National Institute of Allergy and Infectious Diseases in December 2021 with work to be completed primarily in Alabama United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.310 Trans-NIH Research Support.
The Cooperative Agreement was awarded through grant opportunity Nutrition for Precision Health, powered by the All of Us Research Program: Clinical Centers (UG1 Clinical Trial Required).
Status
(Ongoing)
Last Modified 1/28/25
Period of Performance
12/10/21
Start Date
11/30/26
End Date
Funding Split
$8.8M
Federal Obligation
$0.0
Non-Federal Obligation
$8.8M
Total Obligated
Activity Timeline
Transaction History
Modifications to UG1HD107688
Additional Detail
Award ID FAIN
UG1HD107688
SAI Number
UG1HD107688-3118031436
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NT00 NIH EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
YND4PLMC9AN7
Awardee CAGE
0DV74
Performance District
AL-90
Senators
Tommy Tuberville
Katie Britt
Katie Britt
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Office of the Director, National Institutes of Health, Health and Human Services (075-0846) | Health research and training | Grants, subsidies, and contributions (41.0) | $3,129,636 | 100% |
Modified: 1/28/25