UF1MH135970

PERSON-CENTERED DIAGNOSTICS AND PREDICTION FOR CHILD DYSREGULATORY PSYCHOPATHOLOGY USING NOVEL PHENOTYPES - PROJECT SUMMARY THIS U01 PROPOSAL IS SUBMITTED IN RESPONSE TO THE NIMH IMPACT RFA (RFA-MH-23-105). IT WILL EXTEND RESEARCH EFFORTS TO BOTH DEFINE NOVEL, DEPLOYABLE BEHAVIORAL PHENOTYPES (HIGHLIGHTING COGNITIVE AND EMOTIONAL TRANSDIAGNOSTIC MEASURES) AND DEVELOP AND TEST DIAGNOSTIC AND PROGNOSTIC PREDICTION MODELS, USING ADVANCED ANALYTICS, WITHIN THE CLINIC SETTING. IT DOES SO FOR CHILDREN AGED 7-17, PRESENTING WITH COMMON FORMS OF PSYCHOPATHOLOGY, CHARACTERIZED BY DYSREGULATION OF ATTENTION, BEHAVIOR, AND/OR EMOTION. AIM 1 USES ESTABLISHED LONGITUDINAL RESEARCH COHORTS TO FURTHER REFINE COMPUTATIONAL PHENOTYPES FOR COGNITION (EXECUTIVE FUNCTIONS, ALERTNESS/AROUSAL) AND LOW-COST TRAIT RATINGS RELEVANT TO EMOTIONAL REGULATION AND VALENCE, AND IN COMBINATION WITH KEY ENVIRONMENTAL VARIABLES, TESTS THEIR CROSS-SECTIONAL AND LONGITUDINAL PREDICTIVE UTILITY USING MACHINE LEARNING MODELS. AIM 2 USES LARGE ELECTRONIC MEDICAL RECORD (EMR) DATA TO REFINE SOPHISTICATED NEURAL NETWORK MODELS TO ENHANCE MENTAL HEALTH DIAGNOSTICS AND OUTCOME PREDICTION IN CHILDREN. AIMS 3 AND 4 ENTAIL NEW DATA COLLECTION OF SEVERAL THOUSAND PATIENTS IN FOUR PEDIATRIC AND PSYCHIATRY CLINIC SITES AROUND THE COUNTRY, AND THEN COMBINES AND EXTENDS FINDINGS FROM AIMS 1 AND 2 TO TEST THEIR DIAGNOSTIC AND PROGNOSTIC EFFECTIVENESS IN THESE DIVERSE PATIENT POPULATIONS. THE STUDY IS SIGNIFICANT IN ITS POTENTIAL TO OPEN THE WAY FOR CLINICAL CARE TO BENEFIT FROM YEARS OF SCIENTIFIC PROGRESS IN PHENOTYPE REFINEMENT THAT ARE LOW COST AND DEPLOYABLE. IT IS FURTHER SIGNIFICANT IN ITS POTENTIAL TO HARVEST FROM EXISTING EMR DATA FAR MORE CLINICALLY USEFUL PREDICTION ALGORITHMS THAN ARE CURRENTLY AVAILABLE. THE INCLUSION OF SEQUENTIAL BAYESIAN LOGIC FOR AIDING CLINICIANS IN DECIDING WHICH CASES REQUIRE ADDITIONAL ASSESSMENT AND WHICH DO NOT WILL BE TRANSFORMATIVE IN OPENING A PATH FOR SIGNIFICANT SAVINGS IN COST AND CLINICIAN TIME BY IMPROVING EFFICIENCY OF CARE. THE ABILITY TO BETTER PREDICT CRITICAL OUTCOMES, SUCH AS WORSENING OF MENTAL HEALTH SYMPTOMS, SUICIDALITY, OR INCREASED RESOURCE UTILIZATION IS URGENT AND WILL BE ADDRESSED IN OUR WORK. THIS PROJECT IS INNOVATIVE IN COMBINING LARGE MACHINE LEARNING MODELS FROM EMR DATA WITH SIMILAR MODELS USING NOVEL RESEARCH PHENOTYPES AND WILL BE THE FIRST PROSPECTIVE TEST OF THESE MODELS IN PATIENTS RECRUITED FROM ACTIVE CLINICS IN MULTIPLE LOCATIONS TO EVALUATE GENERALIZABILITY. FURTHER SIGNIFICANCE AND INNOVATION ARE ADDED BY CAREFUL ATTENTION TO THE ROLE OF ENVIRONMENTAL ADVERSITY AND EXTENSIVE PLANS TO MINIMIZE OR OVERCOME THE ASYNCHRONOUS BENEFIT OF SUCH EFFORTS TO HISTORICALLY UNDER-SERVED AND UNDER-REPRESENTED POPULATIONS. THE PROJECT DIRECTLY, SIGNIFICANTLY, AND WITH INNOVATION ADDRESSES THE GOALS AND PURPOSE OF THE IMPACT RFA BY AIMING TO DEMONSTRATE HOW NOVEL BEHAVIORAL PHENOTYPES CAN ENHANCE CLINICAL CARE EVEN AS MAXIMUM VALUE IS EXTRACTED FROM EMR DATA ALREADY IN HAND.

Oregon Health & Science University

THE MISSION OF THE NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) IS TO TRANSFORM THE UNDERSTANDING AND TREATMENT OF MENTAL ILLNESSES THROUGH BASIC AND CLINICAL RESEARCH, PAVING THE WAY FOR PREVENTION, RECOVERY, AND CURE. WE FULFILL THIS MISSION BY SUPPORTING AND CONDUCTING RESEARCH ON MENTAL ILLNESSES, HEALTH SERVICES, AND THE UNDERLYING BASIC SCIENCE OF THE BRAIN AND BEHAVIOR; SUPPORTING THE TRAINING OF SCIENTISTS TO CARRY OUT BASIC AND CLINICAL MENTAL HEALTH RESEARCH; AND COMMUNICATING WITH SCIENTISTS, PATIENTS, PROVIDERS, AND THE PUBLIC ABOUT MENTAL HEALTH RESEARCH ADVANCES AND PRIORITIES. IN MAY 2024, NIMH RELEASED ITS STRATEGIC PLAN FOR RESEARCH. THE STRATEGIC PLAN BUILDS ON THE SUCCESSES OF PREVIOUS NIMH STRATEGIC PLANS BY PROVIDING A FRAMEWORK FOR SCIENTIFIC RESEARCH AND EXPLORATION, AND ADDRESSING NEW CHALLENGES IN MENTAL HEALTH.THE NEW STRATEGIC PLAN OUTLINES FOUR HIGH-LEVEL GOALS: GOAL 1: DEFINE THE BRAIN MECHANISMS UNDERLYING COMPLEX BEHAVIORS GOAL 2: EXAMINE MENTAL ILLNESS TRAJECTORIES ACROSS THE LIFESPAN GOAL 3: STRIVE FOR PREVENTION AND CURES GOAL 4: STRENGTHEN THE PUBLIC HEALTH IMPACT OF NIMH-SUPPORTED RESEARCH THESE FOUR GOALS FORM A BROAD ROADMAP FOR THE INSTITUTES RESEARCH PRIORITIES OVER THE NEXT FIVE YEARS, BEGINNING WITH THE FUNDAMENTAL SCIENCE OF THE BRAIN AND BEHAVIOR, AND EXTENDING THROUGH EVIDENCE-BASED SERVICES THAT IMPROVE PUBLIC HEALTH OUTCOMES.

93.242 - Mental Health Research Grants

National Institute of Mental Health (NIMH) [HHS - NIH]

Portland, Oregon 972393011 United States

Single Zip Code

Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) (U01 Clinical Trial Optional) (RFA-MH-23-105)