UF1MH135901

DEVELOPING DATA-DRIVEN CLINICAL SIGNATURES FOR PEOPLE WHO EXPERIENCE HALLUCINATIONS - PROJECT SUMMARY HALLUCINATIONS ARE PREVALENT IN THE CONTEXT OF A WIDE VARIETY OF MENTAL DISORDERS BUT ALSO OCCUR IN APPROXIMATELY 10% OF THE GENERAL POPULATION. HALLUCINATORY EXPERIENCES ARE READILY IDENTIFIABLE BY THOSE EXPERIENCING THEM, BUT THEY ARE NOT ALWAYS INDICATORS OF CONDITIONS THAT LEAD TO SERIOUS NEGATIVE OUTCOMES SUCH AS HOSPITALIZATIONS, USE OF EMERGENCY SERVICES, AND SUICIDE ATTEMPT. OUR RISK EVALUATION CAPABILITIES ARE HAMPERED, IN PART, BY THE LIMITATIONS OF OUR ASSESSMENT STRATEGIES WHICH TYPICALLY INVOLVE RESOURCE INTENSIVE CLINICAL INTERVIEWS, ADMINISTERED BY TRAINED CLINICIANS, IN CLINIC SETTINGS. UBIQUITOUS SMARTPHONE TECHNOLOGIES OFFER US NOVEL OPPORTUNITIES TO ADMINISTER BEHAVIORAL MEASURES THAT CAN CAPTURE THE EXPERIENCE AND IMPACT OF HALLUCINATIONS AT A SCOPE, SCALE, AND ECOLOGICAL VALIDITY THAT FAR EXCEED CLINIC-BASED ASSESSMENT CAPABILITIES. APPLYING POWERFUL COMPUTATIONAL METHODS TO THE RICH DATA COLLECTED USING MOBILE BEHAVIORAL TASKS HAS THE POTENTIAL TO YIELD TOOLS FOR IDENTIFICATION OF THOSE AT HEIGHTENED RISK FOR MAJOR CLINICAL AND FUNCTIONAL IMPAIRMENTS. IN RESPONSE TO RFA-MH-23-105, WE PROPOSE TO RECRUIT A LARGE SAMPLE OF PEOPLE EXPERIENCING HALLUCINATIONS TO INSTALL A SMARTPHONE BEHAVIORAL MEASUREMENT PACKAGE THAT WILL PROMPT THEM TO COMPLETE TARGETED BRIEF SELF-REPORT MEASURES, AUDIO DIARIES DESCRIBING THEIR HALLUCINATORY EXPERIENCES, AND VALIDATED AUDIO-ADMINISTERED VERBAL MEMORY TASKS IN THEIR OWN ENVIRONMENTS. PARTICIPANTS WILL ALSO COMPLETE CLINICAL OUTCOME MEASURES PROSPECTIVELY. OUR TEAM WILL DERIVE DATA-DRIVEN CLINICAL SIGNATURES FROM THE MOBILE BEHAVIORAL TASKS TO PREDICT INDIVIDUAL DIFFERENCES IN SEVERE NEGATIVE OUTCOMES AMONG PEOPLE EXPERIENCING HALLUCINATIONS; IDENTIFY AND MITIGATE INACCURACIES IN MODELLING ACROSS GROUPS DEFINED BY RACE, SEX, AND AGE; EXAMINE WHETHER ADDING SMARTPHONE-CAPTURED BEHAVIORAL DATA TO INFORMATION THAT IS TYPICALLY AVAILABLE IN THE CLINICAL RECORD IMPROVES MODEL CLINICAL UTILITY; AND PRODUCE MACHINE LEARNING-READY DATA STRUCTURES THAT ADHERE TO FAIR (FINDABLE, ACCESSIBLE, INTEROPERABLE, REUSABLE) PRINCIPLES, AND CAN BE SHARED WITH THE BROADER SCIENTIFIC COMMUNITY FOR ONGOING ITERATIVE TESTING AND REFINEMENT. IF SUCCESSFUL, THE PROJECT WILL PRODUCE DATA-DRIVEN TOOLS THAT WILL ADVANCE OUR ABILITY TO ALLOCATE THE RIGHT CLINICAL RESOURCES, AT THE RIGHT TIME, TO THE RIGHT PEOPLE.

University Of Washington

THE MISSION OF THE NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) IS TO TRANSFORM THE UNDERSTANDING AND TREATMENT OF MENTAL ILLNESSES THROUGH BASIC AND CLINICAL RESEARCH, PAVING THE WAY FOR PREVENTION, RECOVERY, AND CURE. WE FULFILL THIS MISSION BY SUPPORTING AND CONDUCTING RESEARCH ON MENTAL ILLNESSES, HEALTH SERVICES, AND THE UNDERLYING BASIC SCIENCE OF THE BRAIN AND BEHAVIOR; SUPPORTING THE TRAINING OF SCIENTISTS TO CARRY OUT BASIC AND CLINICAL MENTAL HEALTH RESEARCH; AND COMMUNICATING WITH SCIENTISTS, PATIENTS, PROVIDERS, AND THE PUBLIC ABOUT MENTAL HEALTH RESEARCH ADVANCES AND PRIORITIES. IN MAY 2024, NIMH RELEASED ITS STRATEGIC PLAN FOR RESEARCH. THE STRATEGIC PLAN BUILDS ON THE SUCCESSES OF PREVIOUS NIMH STRATEGIC PLANS BY PROVIDING A FRAMEWORK FOR SCIENTIFIC RESEARCH AND EXPLORATION, AND ADDRESSING NEW CHALLENGES IN MENTAL HEALTH.THE NEW STRATEGIC PLAN OUTLINES FOUR HIGH-LEVEL GOALS: GOAL 1: DEFINE THE BRAIN MECHANISMS UNDERLYING COMPLEX BEHAVIORS GOAL 2: EXAMINE MENTAL ILLNESS TRAJECTORIES ACROSS THE LIFESPAN GOAL 3: STRIVE FOR PREVENTION AND CURES GOAL 4: STRENGTHEN THE PUBLIC HEALTH IMPACT OF NIMH-SUPPORTED RESEARCH THESE FOUR GOALS FORM A BROAD ROADMAP FOR THE INSTITUTES RESEARCH PRIORITIES OVER THE NEXT FIVE YEARS, BEGINNING WITH THE FUNDAMENTAL SCIENCE OF THE BRAIN AND BEHAVIOR, AND EXTENDING THROUGH EVIDENCE-BASED SERVICES THAT IMPROVE PUBLIC HEALTH OUTCOMES.

93.242 - Mental Health Research Grants

National Institute of Mental Health (NIMH) [HHS - NIH]

Seattle, Washington 981951016 United States

Single Zip Code

Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) (U01 Clinical Trial Optional) (RFA-MH-23-105)