UE5NS065745

RESEARCH TRAINING PROGRAM IN DISEASE-ORIENTED NEUROSCIENCE (R25) - SUMMARY THIS RESEARCH TRAINING PROGRAM IN DISEASE ORIENTED NEUROSCIENCE IS DESIGNED TO FACILITATE THE TRANSITION BETWEEN GRADUATE TRAINING AND A RESEARCH-BASED CAREER IN NEUROLOGY AND NEUROSURGERY. R25 PROGRAM TRAINEES RECEIVE CAREER MENTORING FROM EXPERIENCED CLINICIAN SCIENTISTS IN NEUROLOGY AND NEUROSURGERY ALONG WITH RESEARCH MENTORING FROM LEADING CLINICAL NEUROSCIENCE LABORATORY RESEARCH FACULTY DRAWN FROM MULTIPLE DEPARTMENTS AND SCHOOLS WITHIN THE UNIVERSITY OF PENNSYLVANIA. A FOCUSED EDUCATIONAL PROGRAM SUPPLEMENTS LABORATORY RESEARCH AND INCLUDES TRAINING IN TRANSLATIONAL RESEARCH METHODS, APPLICATIONS, AND THE RESPONSIBLE CONDUCT OF RESEARCH. THE PROGRAM IS CONDUCTED IN A LARGE RESEARCH-ORIENTED INSTITUTION WITH LEADING RESIDENCY PROGRAMS IN ADULT AND CHILD NEUROLOGY AND IN NEUROSURGERY THAT TRAINS SOME OF THE BEST CANDIDATES IN THE COUNTRY AND HAS AN OUTSTANDING TRACK RECORD OF FOSTERING RESEARCH ORIENTED CAREERS AND TRAINEE DIVERSITY. OVER THE PAST PROGRAM PERIOD, 6 OF THE 7 GRADUATING R25 TRAINEES HAVE RECEIVED K AWARDS. THE R25 PATHWAY HAS BEEN FURTHER INTEGRATED INTO THE RESIDENCY TRAINING PROGRAM AT ALL PHASES INCLUDING RESIDENCY APPLICATION REVIEW, APPLICANT VISIT AND INTERVIEW PROCEDURES, ADVANCE MENTORSHIP AND RESEARCH OPPORTUNITIES FOR MATRICULATED APPLICANTS, INTENSIVE SUPPORT FOR THE SELECTION OF MENTORS AND THE DEVELOPMENT OF AN R25 SUPPLEMENT REQUEST, AND MULTIPLE LEVELS OF CLINICIAN SCIENTIST CAREER DEVELOPMENT SUPPORT. BETWEEN THE NEUROLOGY AND NEUROSURGERY RESIDENCIES, THERE ARE OVER 200 FACULTY MEMBERS IN OUR DEPARTMENTS, RANGING FROM MASTER CLINICIANS, CLINICAL EDUCATORS, AND CLINICAL INVESTIGATORS TO PHYSICIAN/SCIENTISTS AND BASIC SCIENTISTS. 80% OF GRADUATING RESIDENTS OVER THE PAST 15 YEARS HAVE REMAINED IN ACADEMIC MEDICINE, AND MANY HAVE CHOSEN CAREERS AS CLINICIAN SCIENTISTS. THE HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA AND CHILDREN'S HOSPITAL OF PHILADELPHIA AT THE PERELMAN SCHOOL OF MEDICINE, WHERE MOST OF THE CLINICAL RESIDENCY AND FELLOWSHIP TRAINING OCCURS, ARE LOCATED WITHIN A HIGHLY COMPACT UNIVERSITY CAMPUS IN WEST PHILADELPHIA SPANNING A RADIUS OF LESS THAN ONE HALF MILE. PENN IS ALSO HOME TO THE FIRST NEUROSCIENCE INSTITUTE IN THE COUNTRY, THE MAHONEY INSTITUTE FOR NEUROSCIENCES, WHICH CONSOLIDATES ALMOST 200 FACULTY MEMBERS FROM 32 DEPARTMENTS AND SIX SCHOOLS ENGAGED IN NEUROSCIENCE RESEARCH AT PENN. THE RANGE OF RESEARCH OPPORTUNITIES FOR OUR R25 TRAINEES CAN THUS BE EXTENDED TO THE WIDER NEUROSCIENCE COMMUNITY INSIDE AND OUTSIDE OF OUR CLINICAL DEPARTMENTS THROUGH CO- MENTORSHIP OF TRAINEES WITH A DIVERSE ARRAY OF EMINENT SCIENTISTS CARRYING OUT RESEARCH RELEVANT TO THE NINDS MISSION TO REDUCE THE BURDEN OF NEUROLOGICAL DISEASE.

Trustees Of The University Of Pennsylvania

(1) TO SUPPORT EXTRAMURAL RESEARCH FUNDED BY THE NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS) INCLUDING: BASIC RESEARCH THAT EXPLORES THE FUNDAMENTAL STRUCTURE AND FUNCTION OF THE BRAIN AND THE NERVOUS SYSTEM, RESEARCH TO UNDERSTAND THE CAUSES AND ORIGINS OF PATHOLOGICAL CONDITIONS OF THE NERVOUS SYSTEM WITH THE GOAL OF PREVENTING THESE DISORDERS, RESEARCH ON THE NATURAL COURSE OF NEUROLOGICAL DISORDERS, IMPROVED METHODS OF DISEASE PREVENTION, NEW METHODS OF DIAGNOSIS AND TREATMENT, DRUG DEVELOPMENT, DEVELOPMENT OF NEURAL DEVICES, CLINICAL TRIALS, AND RESEARCH TRAINING IN BASIC, TRANSLATIONAL AND CLINICAL NEUROSCIENCE. THE INSTITUTE IS THE LARGEST FUNDER OF BASIC NEUROSCIENCE IN THE US AND SUPPORTS RESEARCH ON TOPICS INCLUDING BUT NOT LIMITED TO: DEVELOPMENT OF THE NERVOUS SYSTEM, INCLUDING NEUROGENESIS AND PROGENITOR CELL BIOLOGY, SIGNAL TRANSDUCTION IN DEVELOPMENT AND PLASTICITY, AND PROGRAMMED CELL DEATH, SYNAPSE FORMATION, FUNCTION, AND PLASTICITY, LEARNING AND MEMORY, CHANNELS, TRANSPORTERS, AND PUMPS, CIRCUIT FORMATION AND MODULATION, BEHAVIORAL AND COGNITIVE NEUROSCIENCE, SENSORIMOTOR LEARNING, INTEGRATION AND EXECUTIVE FUNCTION, NEUROENDOCRINE SYSTEMS, SLEEP AND CIRCADIAN RHYTHMS, AND SENSORY AND MOTOR SYSTEMS. IN ADDITION, THE INSTITUTE SUPPORTS BASIC, TRANSLATIONAL AND CLINICAL STUDIES ON A NUMBER OF DISORDERS OF THE NERVOUS SYSTEM INCLUDING (BUT NOT LIMITED TO): STROKE, TRAUMATIC INJURY TO THE BRAIN, SPINAL CORD AND PERIPHERAL NERVOUS SYSTEM, NEURODEGENERATIVE DISORDERS, MOVEMENT DISORDERS, BRAIN TUMORS, CONVULSIVE DISORDERS, INFECTIOUS DISORDERS OF THE BRAIN AND NERVOUS SYSTEM, IMMUNE DISORDERS OF THE BRAIN AND NERVOUS SYSTEM, INCLUDING MULTIPLE SCLEROSIS, DISORDERS RELATED TO SLEEP, AND PAIN. PROGRAMMATIC AREAS, WHICH ARE PRIMARILY SUPPORTED BY THE DIVISION OF NEUROSCIENCE, ARE ALSO SUPPORTED BY THE DIVISION OF EXTRAMURAL ACTIVITIES, THE DIVISION OF TRANSLATIONAL RESEARCH, THE DIVISION OF CLINICAL RESEARCH, THE OFFICE OF TRAINING AND WORKFORCE DEVELOPMENT, THE OFFICE OF PROGRAMS TO ENHANCE NEUROSCIENCE WORKFORCE DEVELOPMENT, AND THE OFFICE OF INTERNATIONAL ACTIVITIES. (2) TO EXPAND AND IMPROVE THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. TO UTILIZE THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM, TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders

National Institute of Neurological Disorders and Stroke (NNDS) [HHS - NIH]

Philadelphia, Pennsylvania 191044238 United States

Single Zip Code

NINDS Research Education Programs for Residents and Fellows in Neurological Disorders and Stroke (R25 - Clinical Trial Not Allowed) (PAR-20-311)

Amendment Since initial award the total obligations have increased 105% from $869,678 to $1,786,374.