U54HD113291

Maternal Health Multilevel Intervention/s for Racial Equity (MIRACLE) Center - Specific Aims (Overall).

The goal of the proposed Multilevel Interventions to Advance Maternal Health Equity (MIRACLE) Center is to reduce pregnancy-related and pregnancy-associated maternal morbidity and mortality (PRAMM) disparities in African American, Hispanic, and rural populations through innovative and culturally relevant community-partnered effectiveness and implementation research.

This center will address the need for multilevel, community-centered, equity-focused interventions developed and tested with an emphasis on scalability and sustainment to address PRAMM disparities.

The proposed MIRACLE Center is innovative because it: (1) tests complementary, multilevel pregnancy-to-postpartum interventions operating across multiple health systems and settings; (2) addresses and measures a wide range of PRAMM conditions (including non-severe morbidity and pregnancy-associated mortality, which are less commonly measured), as well as severe maternal morbidity (SMM) and pregnancy-related mortality; (3) analyzes main effects within each project and synergistic effects across projects, which target different levels and sources of disparities; (4) uses a statewide linked Medicaid dataset (claims, vital records, screening data) to evaluate common outcomes, allowing for data harmonization across projects and with other centers nationally; and (5) focuses on the understudied implementation science concepts of scale-up and sustainment.

The center is significant because it: (1) develops and tests novel approaches to addressing determinants of inequities at multiple levels and in multiple systems, (2) tests these population-level equity-focused interventions in 20 Michigan counties, covering a population of >7 million; and (3) uses an equitably partnered center structure, with academic and health system or community PIs of the center and of each component. All these features enhance utility and impact of the proposed work.

Through three R01-scope projects implementing and testing multilevel interventions, and community partnership and training components, the center will accomplish the following aims: (1) evaluate effectiveness, cost-effectiveness, implementation, and population-wide impact of innovative and culturally relevant multilevel interventions to eliminate PRAMM disparities through three R01-scope projects; (2) generate and scale innovative approaches & partnerships for eliminating PRAMM disparities; (3) maximize scalability, sustainability, cultural relevance, and broad dissemination of identified approaches; (4) increase research, practice, and policy capacity for eliminating PRAMM disparities.

This center is rooted in a culturally informed multi-disciplinary research community with involvement of longstanding community, health, and policy partners in all phases of the center's work, and partnership with Black and Hispanic Medicaid-eligible mothers and their families in urban and rural settings.

With in-kind financial support from academic and health institutions, the center will generate scalable and sustainable approaches for saving maternal lives and ending preventable and unequal maternal suffering.

Henry Ford Health + Michigan State University Health Sciences

TO CONDUCT AND SUPPORT LABORATORY RESEARCH, CLINICAL TRIALS, AND STUDIES WITH PEOPLE THAT EXPLORE HEALTH PROCESSES. NICHD RESEARCHERS EXAMINE GROWTH AND DEVELOPMENT, BIOLOGIC AND REPRODUCTIVE FUNCTIONS, BEHAVIOR PATTERNS, AND POPULATION DYNAMICS TO PROTECT AND MAINTAIN THE HEALTH OF ALL PEOPLE. TO EXAMINE THE IMPACT OF DISABILITIES, DISEASES, AND DEFECTS ON THE LIVES OF INDIVIDUALS. WITH THIS INFORMATION, THE NICHD HOPES TO RESTORE, INCREASE, AND MAXIMIZE THE CAPABILITIES OF PEOPLE AFFECTED BY DISEASE AND INJURY. TO SPONSOR TRAINING PROGRAMS FOR SCIENTISTS, DOCTORS, AND RESEARCHERS TO ENSURE THAT NICHD RESEARCH CAN CONTINUE. BY TRAINING THESE PROFESSIONALS IN THE LATEST RESEARCH METHODS AND TECHNOLOGIES, THE NICHD WILL BE ABLE TO CONDUCT ITS RESEARCH AND MAKE HEALTH RESEARCH PROGRESS UNTIL ALL CHILDREN, ADULTS, FAMILIES, AND POPULATIONS ENJOY GOOD HEALTH. THE MISSION OF THE NICHD IS TO ENSURE THAT EVERY PERSON IS BORN HEALTHY AND WANTED, THAT WOMEN SUFFER NO HARMFUL EFFECTS FROM REPRODUCTIVE PROCESSES, AND THAT ALL CHILDREN HAVE THE CHANCE TO ACHIEVE THEIR FULL POTENTIAL FOR HEALTHY AND PRODUCTIVE LIVES, FREE FROM DISEASE OR DISABILITY, AND TO ENSURE THE HEALTH, PRODUCTIVITY, INDEPENDENCE, AND WELL-BEING OF ALL PEOPLE THROUGH OPTIMAL REHABILITATION.

93.865 - Child Health and Human Development Extramural Research

National Institute of Child Health and Human Development (NICHD) [HHS - NIH]

East Lansing, Michigan 488242600 United States

Single Zip Code

Maternal Health Research Centers of Excellence (U54 Clinical Trial Optional) (RFA-HD-23-035)

Amendment Since initial award the total obligations have increased 100% from $2,687,186 to $5,376,134.