U54DK137314
Cooperative Agreement
Overview
Grant Description
University of Michigan O'Brien Kidney Translational Resource Center (MKTC) - Abstract – Center Overview
The main goal of the University of Michigan O'Brien Kidney Translational Resource Center (MKTC) is to provide an effective translational research pipeline to develop novel, mechanistic treatment strategies for patients with kidney diseases.
The center will support all basic and patient-oriented kidney research investigators using a 3-pronged approach: enable investigators to investigate the molecular causes and endpoints of acute and chronic kidney diseases; dissemination and support of the most modern and powerful systems biological approaches for all investigators to help them effectively identify novel and robust biomarkers, endpoints, and targets for diagnosis and treatment of AKI and CKD; expert analysis and integration of cohort and systems data for our research base investigators through the use of sophisticated bioinformatics and database integration that promote identification of specific pathways and targets for treatments for individuals or groups of subjects with AKI and CKD.
The center's aims are to:
1) Introduce, stimulate, and apply state-of-the-art systems biological approaches to kidney disease research investigators through the use of sophisticated but user-friendly genetic, transcriptomic, proteomic, metabolomic, and lipidomic approaches through the Applied Systems Biology Core.
2) Enhance the understanding of complex kidney diseases and the multi-scalar data sets that accompany systems biological approaches to their functional implications regarding kidney disease development, diagnosis, progression, and therapeutic potential through the Data Analytic Services Core (DASC).
3) Serve as a national resource and expand worldwide outreach efforts via NephroSeq, NephroCell, and TranSmart.
4) Use the student programs and robust enrichment programs to entice trainees and faculty into kidney research, improve diversity, equity, and inclusion, and support researchers in their ongoing kidney research.
5) Share best practices and resources with the other national resource centers under the U54 Consortium and work with the Data Coordinating Center to enable widespread dissemination.
The main goal of the University of Michigan O'Brien Kidney Translational Resource Center (MKTC) is to provide an effective translational research pipeline to develop novel, mechanistic treatment strategies for patients with kidney diseases.
The center will support all basic and patient-oriented kidney research investigators using a 3-pronged approach: enable investigators to investigate the molecular causes and endpoints of acute and chronic kidney diseases; dissemination and support of the most modern and powerful systems biological approaches for all investigators to help them effectively identify novel and robust biomarkers, endpoints, and targets for diagnosis and treatment of AKI and CKD; expert analysis and integration of cohort and systems data for our research base investigators through the use of sophisticated bioinformatics and database integration that promote identification of specific pathways and targets for treatments for individuals or groups of subjects with AKI and CKD.
The center's aims are to:
1) Introduce, stimulate, and apply state-of-the-art systems biological approaches to kidney disease research investigators through the use of sophisticated but user-friendly genetic, transcriptomic, proteomic, metabolomic, and lipidomic approaches through the Applied Systems Biology Core.
2) Enhance the understanding of complex kidney diseases and the multi-scalar data sets that accompany systems biological approaches to their functional implications regarding kidney disease development, diagnosis, progression, and therapeutic potential through the Data Analytic Services Core (DASC).
3) Serve as a national resource and expand worldwide outreach efforts via NephroSeq, NephroCell, and TranSmart.
4) Use the student programs and robust enrichment programs to entice trainees and faculty into kidney research, improve diversity, equity, and inclusion, and support researchers in their ongoing kidney research.
5) Share best practices and resources with the other national resource centers under the U54 Consortium and work with the Data Coordinating Center to enable widespread dissemination.
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Ann Arbor,
Michigan
481091276
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 291% from $965,126 to $3,777,827.
Regents Of The University Of Michigan was awarded
Advanced Kidney Disease Research Center - Innovating Treatments & Biomarkers
Cooperative Agreement U54DK137314
worth $3,777,827
from the National Institute of Diabetes and Digestive and Kidney Diseases in September 2023 with work to be completed primarily in Ann Arbor Michigan United States.
The grant
has a duration of 4 years 9 months and
was awarded through assistance program 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
The Cooperative Agreement was awarded through grant opportunity George M. O'Brien Kidney National Resource Centers (U54 - Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 7/20/26
Period of Performance
9/1/23
Start Date
6/30/28
End Date
Funding Split
$3.8M
Federal Obligation
$0.0
Non-Federal Obligation
$3.8M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for U54DK137314
Transaction History
Modifications to U54DK137314
Additional Detail
Award ID FAIN
U54DK137314
SAI Number
U54DK137314-1483521505
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NK00 NIH National Institute of Diabetes and Digestive and Kidney Diseases
Funding Office
75NK00 NIH National Institute of Diabetes and Digestive and Kidney Diseases
Awardee UEI
GNJ7BBP73WE9
Awardee CAGE
03399
Performance District
MI-06
Senators
Debbie Stabenow
Gary Peters
Gary Peters
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Health and Human Services (075-0884) | Health research and training | Grants, subsidies, and contributions (41.0) | $965,126 | 100% |
Modified: 7/20/26