U54DE035412

360° COLLABORATIVE HUB FOR AI IN TMD RESEARCH (360° CHAT-TMD) - 360° CHAT TMD ABSTRACT THE PROPOSED 360° COLLABORATIVE HUB FOR AI IN TMD RESEARCH (360° CHAT-TMD) CENTER WILL ESTABLISH A NATIONAL, INTERDISCIPLINARY, PATIENT-CENTERED INITIATIVE AIMED AT ADVANCING TEMPOROMANDIBULAR DISORDER (TMD) RESEARCH AND IMPROVING CLINICAL CARE. BY UNITING EXPERTS FROM THE UNIVERSITY OF MICHIGAN, HARVARD UNIVERSITY, AND MASS GENERAL BRIGHAM, ALONGSIDE PATIENT COMMUNITIES, THE PROJECT SEEKS TO BRIDGE CRITICAL KNOWLEDGE GAPS IN TMD AND CHRONIC OVERLAPPING PAIN CONDITIONS (COPCS). THE COLLABORATIVE FOCUSES ON FOUR KEY OBJECTIVES: CREATING AN INTEGRATED COMPUTATIONAL AND DATA SCIENCE INFRASTRUCTURE, IMPLEMENTING STANDARDIZED TRAINING PROGRAMS, CONDUCTING INTERDISCIPLINARY RESEARCH TO UNCOVER TMD MECHANISMS, AND ENHANCING COLLABORATION THROUGH INNOVATIVE TECHNOLOGIES. THE PROJECT IS STRUCTURED AROUND TWO CORES AND TWO RESEARCH PROJECTS. THE BIOINFORMATICS AND DATA SCIENCE CORE (BDSC) SERVES AS THE COMPUTATIONAL AND ANALYTICAL HUB, ESTABLISHING TMD-SPECIFIC COMMON DATA ELEMENTS (CDES) AND HARMONIZED DATA INTEGRATION PIPELINES. IT LEVERAGES ADVANCED AI/ML TECHNIQUES FOR MULTI-MODAL DISEASE PHENOTYPING, FOSTERS COLLABORATION THROUGH SECURE, PRIVACY-PRESERVING DATA-SHARING ECOSYSTEMS, AND PROVIDES BIOSTATISTICAL AND DATA SCIENCE EXPERTISE TO STUDY TMD SUBTYPES, PROGRESSION, AND TREATMENT OUTCOMES. THE OUTREACH AND TRAINING CORE (OTEC) FOCUSES ON EDUCATION AND TRAINING, ENHANCING ACCESSIBILITY TO TMD/COPCS RESOURCES FOR MEDICALLY UNDERSERVED POPULATIONS AND DEVELOPING CAREER DEVELOPMENT PROGRAMS TO MENTOR THE NEXT GENERATION OF CLINICIAN-SCIENTISTS. RESEARCH PROJECT 1 EMPLOYS A MULTI-LEVEL APPROACH TO UNDERSTAND TMD MECHANISMS, USING ANIMAL MODELS TO STUDY STRUCTURAL CHANGES, PAIN, AND DYSFUNCTION, WHILE EXPLORING THERAPEUTIC STRATEGIES TARGETING PATHWAYS LIKE HEDGEHOG SIGNALING AND INFLAMMATION. RESEARCH PROJECT 2 INTEGRATES AI/ML TECHNOLOGIES FOR WHOLE-PERSON, WHOLE-HEALTHCARE, AND WHOLE-COMMUNITY RESEARCH. IT AIMS TO CLASSIFY TMD SUBTYPES, PREDICT PROGRESSION, AND IMPLEMENT MOBILE CLINICAL CHATBOTS FOR REMOTE OUTREACH AND PATIENT CLASSIFICATION. TOGETHER, THESE EFFORTS ALIGN WITH NIDCR’S IMPACT MISSION AND AIM TO TRANSFORM TMD RESEARCH, IMPROVE CLINICAL CARE, AND ULTIMATELY ENHANCE THE QUALITY OF LIFE FOR PATIENTS SUFFERING FROM TMD AND RELATED CHRONIC PAIN CONDITIONS.

Regents Of The University Of Michigan

NIDCR EXTRAMURAL RESEARCH PROVIDES RESEARCH FUNDS TO SUPPORT BASIC, TRANSLATIONAL, AND CLINICAL RESEARCH IN DENTAL, ORAL, AND CRANIOFACIAL HEALTH AND DISEASE THROUGH GRANTS, COOPERATIVE AGREEMENTS, AND CONTRACTS THAT SUPPORT SCIENTISTS WORKING IN INSTITUTIONS THROUGHOUT THE UNITED STATES AND INTERNATIONALLY. EXTRAMURAL PROGRAMS PLAN, DEVELOP, AND MANAGE SCIENTIFIC PRIORITIES THROUGH PORTFOLIO ANALYSES AND CONSULTATION WITH STAKEHOLDERS, ENCOURAGING THE MOST PROMISING DISCOVERIES AND EMERGING TECHNOLOGIES FOR RAPID TRANSLATION TO CLINICAL APPLICATIONS. THE INTEGRATIVE BIOLOGY AND INFECTIOUS DISEASES PROGRAMS SUPPORTS BASIC AND TRANSLATIONAL RESEARCH PROGRAMS ON ORAL MICROBIOLOGY, SALIVARY BIOLOGY AND IMMUNOLOGY, ORAL AND SALIVARY GLAND CANCERS, NEUROSCIENCE OF OROFACIAL PAIN AND TEMPOROMANDIBULAR DISORDERS, MINERALIZED TISSUE PHYSIOLOGY, DENTAL BIOMATERIALS, AND TISSUE ENGINEERING AND REGENERATIVE MEDICINE. THE BRANCH AIMS TO ACCELERATE PROGRESS IN BASIC AND TRANSLATIONAL RESEARCH IN THESE AREAS, AND FURTHER STIMULATE THE DISCOVERY PIPELINE BASED ON CLINICAL NEEDS. THE TRANSLATIONAL GENOMICS RESEARCH PROGRAMS SUPPORTS BASIC AND TRANSLATIONAL RESEARCH IN GENETICS, GENOMICS, DEVELOPMENTAL BIOLOGY, AND DATA SCIENCE TOWARD THE GOAL OF IMPROVING DENTAL, ORAL, AND CRANIOFACIAL HEALTH. THE FOCUS IS ON DECIPHERING THE GENETIC, MOLECULAR, AND CELLULAR MECHANISMS UNDERLYING DENTAL, ORAL, AND CRANIOFACIAL DEVELOPMENT AND ANOMALIES. THE BEHAVIORAL AND SOCIAL SCIENCES RESEARCH PROGRAMS SUPPORTS BASIC AND APPLIED RESEARCH TO PROMOTE ORAL HEALTH, TO PREVENT ORAL DISEASES AND RELATED DISABILITIES, AND TO IMPROVE MANAGEMENT OF CRANIOFACIAL CONDITIONS, DISORDERS, AND INJURY. THE PROGRAM PRIORITIZES MECHANISTIC RESEARCH THAT CONTRIBUTES TO A CUMULATIVE SCIENCE OF BEHAVIOR CHANGE, TO MAXIMIZE THE RIGOR, RELEVANCE, AND DISSEMINATION OF EFFICACIOUS BEHAVIOR CHANGE INTERVENTIONS. THE CLINICAL RESEARCH PROGRAMS SUPPORTS PATIENT-ORIENTED, POPULATION, AND COMMUNITY BASED RESEARCH AIMED AT IMPROVING THE DENTAL, ORAL, AND CRANIOFACIAL HEALTH OF THE NATION. THE CENTER FOCUSES ON A VARIETY OF DISEASES AND CONDITIONS THROUGH CLINICAL TRIALS, EPIDEMIOLOGIC STUDIES, PRACTICE-BASED RESEARCH, THE HIV/AIDS AND ORAL HEALTH PROGRAM, AND STUDIES OF ORAL HEALTH DISPARITIES AND INEQUITIES IN ALL AREAS OF NIDCR PROGRAMMATIC INTEREST. THE PROGRAM ENCOURAGES INVESTIGATIONS THAT HAVE THE POTENTIAL TO TRANSLATE FINDINGS INTO EVIDENCE-BASED CLINICAL APPLICATIONS. THE RESEARCH TRAINING AND CAREER DEVELOPMENT EXTRAMURAL PROGRAMS SPAN THE CAREER STAGES OF SCIENTISTS, SUPPORTING RESEARCH TRAINING AND CAREER DEVELOPMENT FOR PHD AND DUAL DEGREE DDS/DMD-PHD STUDENTS, POSTDOCTORAL SCHOLARS, AND EARLY CAREER, MIDCAREER, AND ESTABLISHED INVESTIGATORS. THE PROGRAMS MANAGE SUPPORT FOR FELLOWSHIPS, RESEARCH TRAINING GRANTS, CAREER DEVELOPMENT AND CAREER TRANSITION AWARDS, NIH LOAN REPAYMENT AWARDS, AND DIVERSITY SUPPLEMENTS TO SUPPORT RESEARCH EXPERIENCES FOR HIGH SCHOOL STUDENTS THROUGH INVESTIGATORS. NIDCR PARTICIPATES IN THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) AND SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAMS. THE SBIR PROGRAM IS INTENDED TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.THE STTR PROGRAM IS INTENDED TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. EXTRAMURAL PROGRAMS ARE ACCOUNTABLE FOR THE EFFICIENT AND EFFECTIVE USE OF TAXPAYER FUNDS TO SUPPORT RESEARCH ON DENTAL, ORAL, AND CRANIOFACIAL DISEASES AND DISORDERS AND IMPROVING THE ORAL HEALTH OF ALL AMERICANS. EXTRAMURAL PROGRAMS SUPPORT RESEARCH AND RESEARCH TRAINING TO ESTABLISH THE FOUNDATION FOR SCIENTIFIC DISCOVERIES THAT INCLUDE TRANSPARENT AND RIGOROUS PLANNING, PRIORITY SETTING, CONTINUOUS AND CONSISTENT REVIEWS OF PROGRESS, AND FOCUS ON THE DEVELOPMENT OF A DIVERSE, HIGHLY SKILLED, AND NIMBLE WORKFORCE THAT CAN RAPIDLY RESPOND TO SCIENTIFIC BREAKTHROUGHS AND PUBLIC HEALTH CHALLENGES. EXTRAMURAL PROGRAMS ARE ACCOUNTABLE FOR THE EFFICIENT AND EFFECTIVE USE OF TAXPAYER FUNDS TO SUPPORT RESEARCH ON DENTAL, ORAL, AND CRANIOFACIAL DISEASES AND EMPLOY EVALUATION DOMAINS, FROM NEEDS ASSESSMENT AND STRATEGIC PLANNING TO IMPLEMENTATION AND PROCESS EVALUATION, PERFORMANCE MEASUREMENT, AND OUTCOMES AND IMPACT ANALYSIS TO EVALUATE STRATEGIC OBJECTIVES

93.213 - Research and Training in Complementary and Integrative Health

National Institute of Dental and Craniofacial Research (NIDCR) [HHS - NIH]

National Center for Complementary and Integrative Health (NCCIH) [HHS - NIH]

Ann Arbor, Michigan 481091276 United States

Single Zip Code

TMD Collaborative for IMproving PAtient-Centered Translational Research (TMD IMPACT) (U54 Clinical Trial Optional) (RFA-DE-25-003)

Amendment Since initial award the total obligations have increased 906% from $300,000 to $3,017,704.