U54AR081774
Cooperative Agreement
Overview
Grant Description
3D Multiscale Reference Atlas for Human Skin
The scientific focus of the proposed 3D Multiscale Reference Atlas for Human Skin is to develop the first comprehensive, three-dimensional set of integrated cellular and molecular maps of human skin across age, sex, race, and skin location.
Skin is the largest human organ, serving as a critical barrier between the external environment and internal tissues. However, there is currently no comprehensive map of the three-dimensional architecture of this organ at a cellular level, nor is there a comprehensive map of the molecular signatures defining this architecture across the body and across lifespan.
Here, we will integrate our recently developed machine learning-guided image analysis system, CODA, with single-cell and spatial multi-omic analyses to produce high-content reference maps. The integrated skin atlas will allow researchers to interrogate the skin in its entire three-dimensional architecture, focusing on individual structures such as the vasculature or hair follicles, or individual cells.
We will overlay genotypic and phenotypic states to enable examination of the overlap between senescent cells and stem cells, or the correlation between extracellular matrix (ECM) content and the diversity of dermal fibroblasts. By including diverse and often underrepresented populations, our multiscale atlas will provide a broader view of skin biology, filling in critical missing information.
Furthermore, by looking across lifespan, the atlas will provide a view of architectural, cellular, and molecular alterations in skin with age, establishing the natural history of normal biology for this critical organ.
In addition to its native value for understanding skin itself, we anticipate that our skin atlas will be a powerful hypothesis-generating tool for biologists studying the many questions for which skin is an ideal model system – homeostatic renewal, repair, senescence, aging, and pathogen response.
The scientific focus of the proposed 3D Multiscale Reference Atlas for Human Skin is to develop the first comprehensive, three-dimensional set of integrated cellular and molecular maps of human skin across age, sex, race, and skin location.
Skin is the largest human organ, serving as a critical barrier between the external environment and internal tissues. However, there is currently no comprehensive map of the three-dimensional architecture of this organ at a cellular level, nor is there a comprehensive map of the molecular signatures defining this architecture across the body and across lifespan.
Here, we will integrate our recently developed machine learning-guided image analysis system, CODA, with single-cell and spatial multi-omic analyses to produce high-content reference maps. The integrated skin atlas will allow researchers to interrogate the skin in its entire three-dimensional architecture, focusing on individual structures such as the vasculature or hair follicles, or individual cells.
We will overlay genotypic and phenotypic states to enable examination of the overlap between senescent cells and stem cells, or the correlation between extracellular matrix (ECM) content and the diversity of dermal fibroblasts. By including diverse and often underrepresented populations, our multiscale atlas will provide a broader view of skin biology, filling in critical missing information.
Furthermore, by looking across lifespan, the atlas will provide a view of architectural, cellular, and molecular alterations in skin with age, establishing the natural history of normal biology for this critical organ.
In addition to its native value for understanding skin itself, we anticipate that our skin atlas will be a powerful hypothesis-generating tool for biologists studying the many questions for which skin is an ideal model system – homeostatic renewal, repair, senescence, aging, and pathogen response.
Awardee
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding Agency
Place of Performance
Maryland
United States
Geographic Scope
State-Wide
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 119% from $500,000 to $1,095,794.
The Johns Hopkins University was awarded
3D Multiscale Reference Atlas for Human Skin
Cooperative Agreement U54AR081774
worth $1,095,794
from the National Institute of Allergy and Infectious Diseases in September 2022 with work to be completed primarily in Maryland United States.
The grant
has a duration of 2 years and
was awarded through assistance program 93.310 Trans-NIH Research Support.
The Cooperative Agreement was awarded through grant opportunity Tissue Mapping Centers for the Human BioMolecular Atlas Program (U54 Clinical Trial Not Allowed).
Status
(Complete)
Last Modified 3/20/25
Period of Performance
9/26/22
Start Date
8/31/24
End Date
Funding Split
$1.1M
Federal Obligation
$0.0
Non-Federal Obligation
$1.1M
Total Obligated
Activity Timeline
Transaction History
Modifications to U54AR081774
Additional Detail
Award ID FAIN
U54AR081774
SAI Number
U54AR081774-1373222488
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Private Institution Of Higher Education
Awarding Office
75NB00 NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
FTMTDMBR29C7
Awardee CAGE
5L406
Performance District
MD-90
Senators
Benjamin Cardin
Chris Van Hollen
Chris Van Hollen
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Office of the Director, National Institutes of Health, Health and Human Services (075-0846) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,095,794 | 100% |
Modified: 3/20/25