U54AG090792

Microphysiological systems to advance precision medicine for Alzheimer's disease and related dementias (MAP-AD) - Project abstract/summary

IU MAP-AD overall abstract/summary

The Indiana University microphysiological systems to advance precision medicine for AD/ADRD (IUMAP-AD) center is committed to establishing a multi-component Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD) translational center for microphysiological systems (MPS).

AD is a leading cause of dementia worldwide, with current estimates of nearly 6 million Americans currently affected by the disease.

AD is associated with many accompanying pathologies including inflammation and activation of microglia and astrocytes, dysfunction of vasculature, as well as synaptic and eventual neuronal loss.

Additionally, recent studies have identified numerous genetic risk factors associated with AD/ADRD at loci with known functions in glial and vascular cell types.

However, our understanding of how these genetic risk factors and cell types contribute to AD/ADRD pathology remains somewhat limited, especially in the human system.

Thus, to overcome these shortcomings, we propose to build on our extensive knowledge and tools acquired from the ongoing MODEL-AD, TREAT-AD, and CLEAR-AD consortia at Indiana University, as well as our extensive expertise in induced pluripotent stem cell (iPSC)/organoids, intelligent systems, and AD/ADRD research across the university.

Our overarching goal is to develop reproducible, scalable, and standardized 3D brain organoid-based MPS models that recapitulate key features of human AD/ADRD pathophysiology.

In the process, we will also generate numerous resources for investigation among the research community which will be readily shared, including novel cell lines, protocols for the development and implementation of MPS models, and datasets derived from the use of MPS models.

These models will thus serve as precision medicine research tools to investigate the complex biology of AD/ADRD and accelerate multiple aspects of drug discovery and preclinical drug development.

Trustees Of Indiana University

TO ENCOURAGE BIOMEDICAL, SOCIAL, AND BEHAVIORAL RESEARCH AND RESEARCH TRAINING DIRECTED TOWARD GREATER UNDERSTANDING OF THE AGING PROCESS AND THE DISEASES, SPECIAL PROBLEMS, AND NEEDS OF PEOPLE AS THEY AGE. THE NATIONAL INSTITUTE ON AGING HAS ESTABLISHED PROGRAMS TO PURSUE THESE GOALS. THE DIVISION OF AGING BIOLOGY EMPHASIZES UNDERSTANDING THE BASIC BIOLOGICAL PROCESSES OF AGING. THE DIVISION OF GERIATRICS AND CLINICAL GERONTOLOGY SUPPORTS RESEARCH TO IMPROVE THE ABILITIES OF HEALTH CARE PRACTITIONERS TO RESPOND TO THE DISEASES AND OTHER CLINICAL PROBLEMS OF OLDER PEOPLE. THE DIVISION OF BEHAVIORAL AND SOCIAL RESEARCH SUPPORTS RESEARCH THAT WILL LEAD TO GREATER UNDERSTANDING OF THE SOCIAL, CULTURAL, ECONOMIC AND PSYCHOLOGICAL FACTORS THAT AFFECT BOTH THE PROCESS OF GROWING OLD AND THE PLACE OF OLDER PEOPLE IN SOCIETY. THE DIVISION OF NEUROSCIENCE FOSTERS RESEARCH CONCERNED WITH THE AGE-RELATED CHANGES IN THE NERVOUS SYSTEM AS WELL AS THE RELATED SENSORY, PERCEPTUAL, AND COGNITIVE PROCESSES ASSOCIATED WITH AGING AND HAS A SPECIAL EMPHASIS ON ALZHEIMER'S DISEASE. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

Indianapolis, Indiana 462022266 United States

Single Zip Code

Microphysiological Systems to Advance Precision Medicine for AD/ADRD Treatment and Prevention (U54 Clinical Trial Not Allowed) (RFA-AG-24-040)