U54AG075941
Cooperative Agreement
Overview
Grant Description
The Kapp-Sen Tissue Mapping Center Collaborative - Project Summary
Overall, this proposal seeks to establish the Kapp-Sen Tissue Mapping Center Collaborative (TMC) as part of the Cellular Senescence Network: Tissue Mapping Centers effort (RFA-RM-21-008). Our application represents a multidisciplinary collaborative effort involving six leading institutions and aging research programs working together to characterize the distribution and biological heterogeneity of senescent cells in different healthy human tissues. This effort is in full alignment with the objectives of the Cellular Senescence Network (SenNet).
Kapp-Sen brings together the skills, resources, and perspectives needed to address SenNet goals in the framework of the healthy human kidney, adipose tissues, pancreas, and placenta. Additionally, due to our ability to obtain full thickness skin tissues from individuals providing Kapp samples, we may explore the possibility of future collaborative studies with TMCs selected for their major focus on skin.
Our six collaborating institutions located in Farmington, CT (UCONN Health, Jackson Laboratory for Genomic Medicine), Boston (Brigham & Women's Hospital, Joslin Diabetes Center), Rochester, MN (Mayo Clinic), and San Antonio, TX (UTHCSA) have all been carefully selected for their essential and unique individual contributions to the field and this effort.
Our objectives will be achieved through the following aims:
Aim 1: Coordinate research activities across Kapp-Sen TMC collaborative sites in support of SenNet goals towards mapping cellular senescence and its associated secretory phenotype in the healthy human kidney, adipose tissues, pancreas, and placenta.
Aim 2: Obtain tissues from healthy kidney transplant donors (kidneys, fat, skin), C-section pregnancies (placenta, cord, fat, skin), outpatient healthy donor biopsies (fat, skin), beating heart brain dead donors (full pancreas), and IIPD/PRODO (dispersed pancreas).
Aim 3: Generate highest quality data pertaining to cellular senescence, including scRNA-seq, snRNA-seq, spatial transcriptomics, immunohistochemistry, and telomere-associated DDR foci (TAFs) in all tissues.
Aim 4: Perform high-level integrative data analysis required for the creation of atlases of human cellular senescence in collaboration with other TMCs, CODDC, and NIH staff.
Overall, this proposal seeks to establish the Kapp-Sen Tissue Mapping Center Collaborative (TMC) as part of the Cellular Senescence Network: Tissue Mapping Centers effort (RFA-RM-21-008). Our application represents a multidisciplinary collaborative effort involving six leading institutions and aging research programs working together to characterize the distribution and biological heterogeneity of senescent cells in different healthy human tissues. This effort is in full alignment with the objectives of the Cellular Senescence Network (SenNet).
Kapp-Sen brings together the skills, resources, and perspectives needed to address SenNet goals in the framework of the healthy human kidney, adipose tissues, pancreas, and placenta. Additionally, due to our ability to obtain full thickness skin tissues from individuals providing Kapp samples, we may explore the possibility of future collaborative studies with TMCs selected for their major focus on skin.
Our six collaborating institutions located in Farmington, CT (UCONN Health, Jackson Laboratory for Genomic Medicine), Boston (Brigham & Women's Hospital, Joslin Diabetes Center), Rochester, MN (Mayo Clinic), and San Antonio, TX (UTHCSA) have all been carefully selected for their essential and unique individual contributions to the field and this effort.
Our objectives will be achieved through the following aims:
Aim 1: Coordinate research activities across Kapp-Sen TMC collaborative sites in support of SenNet goals towards mapping cellular senescence and its associated secretory phenotype in the healthy human kidney, adipose tissues, pancreas, and placenta.
Aim 2: Obtain tissues from healthy kidney transplant donors (kidneys, fat, skin), C-section pregnancies (placenta, cord, fat, skin), outpatient healthy donor biopsies (fat, skin), beating heart brain dead donors (full pancreas), and IIPD/PRODO (dispersed pancreas).
Aim 3: Generate highest quality data pertaining to cellular senescence, including scRNA-seq, snRNA-seq, spatial transcriptomics, immunohistochemistry, and telomere-associated DDR foci (TAFs) in all tissues.
Aim 4: Perform high-level integrative data analysis required for the creation of atlases of human cellular senescence in collaboration with other TMCs, CODDC, and NIH staff.
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding Agency
Place of Performance
Farmington,
Connecticut
06032
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 413% from $2,700,000 to $13,842,784.
University Of Connecticut Health Center was awarded
KAPP-SEN Tissue Mapping Center Collaborative - SenNet Goals.
Cooperative Agreement U54AG075941
worth $13,842,784
from the National Institute of Allergy and Infectious Diseases in September 2021 with work to be completed primarily in Farmington Connecticut United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.310 Trans-NIH Research Support.
The Cooperative Agreement was awarded through grant opportunity Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional).
Status
(Ongoing)
Last Modified 9/5/25
Period of Performance
9/30/21
Start Date
8/31/26
End Date
Funding Split
$13.8M
Federal Obligation
$0.0
Non-Federal Obligation
$13.8M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for U54AG075941
Transaction History
Modifications to U54AG075941
Additional Detail
Award ID FAIN
U54AG075941
SAI Number
U54AG075941-1550771808
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75NN00 NIH National Insitute on Aging
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
H6D6JMXJXDE6
Awardee CAGE
1G782
Performance District
CT-05
Senators
Richard Blumenthal
Christopher Murphy
Christopher Murphy
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Office of the Director, National Institutes of Health, Health and Human Services (075-0846) | Health research and training | Grants, subsidies, and contributions (41.0) | $5,400,000 | 100% |
Modified: 9/5/25