U42OD035738
Cooperative Agreement
Overview
Grant Description
Swine Somatic Cell Gene Editing Testing Center - Project Summary:
Overall, the overall purpose of this project is to provide services to the somatic cell genome editing community. Those serviced include to 1) produce, import, cryopreserve, and supply swine biomedical models for the somatic cell genome editing research community, 2) evaluate the safety and efficacy of somatic cell genome editing strategies, and 3) determine the therapeutic value, window of opportunity, and duration of therapies.
It is anticipated that these services will advance basic research through testing of novel reagents as well as facilitating translation of therapeutic interventions into the clinic.
The role of the Genome Editing Coordination Section will be to manage communication and logistics associated with Swine SCGE Center. These responsibilities include reporting to NIH and regulatory agencies when appropriate as well as communicating with center users, the program steering committee, and various collaborators.
The role of the Genome Editing Resource Section will be to produce, import, cryopreserve, validate, and supply unique swine models. The resource section will also maintain breeding colonies and produce cohorts of experimental animals, and it will be responsible for assembly and maintenance of BSL2 facilities for use by the testing section.
The role of the Genome Editing Testing Section will be to provide novel delivery methods and reagents for the somatic cell genome editing community. The genome editing testing section will streamline the testing process while maintaining a comprehensive and rigorous comparative analysis of new genome editing tools and delivery systems.
Our group is ideally suited to provide this testing due to our unique composition of individuals that are experienced with pig production, swine biomedical models, operate successful labs that routinely test cutting-edge genome editing technology, and are associated with world-renowned National Swine Resource and Research Center (NSRRC) and the sunsetting Swine Somatic Cell Genome Editing Consortium Large Animal Testing Center.
Overall, the overall purpose of this project is to provide services to the somatic cell genome editing community. Those serviced include to 1) produce, import, cryopreserve, and supply swine biomedical models for the somatic cell genome editing research community, 2) evaluate the safety and efficacy of somatic cell genome editing strategies, and 3) determine the therapeutic value, window of opportunity, and duration of therapies.
It is anticipated that these services will advance basic research through testing of novel reagents as well as facilitating translation of therapeutic interventions into the clinic.
The role of the Genome Editing Coordination Section will be to manage communication and logistics associated with Swine SCGE Center. These responsibilities include reporting to NIH and regulatory agencies when appropriate as well as communicating with center users, the program steering committee, and various collaborators.
The role of the Genome Editing Resource Section will be to produce, import, cryopreserve, validate, and supply unique swine models. The resource section will also maintain breeding colonies and produce cohorts of experimental animals, and it will be responsible for assembly and maintenance of BSL2 facilities for use by the testing section.
The role of the Genome Editing Testing Section will be to provide novel delivery methods and reagents for the somatic cell genome editing community. The genome editing testing section will streamline the testing process while maintaining a comprehensive and rigorous comparative analysis of new genome editing tools and delivery systems.
Our group is ideally suited to provide this testing due to our unique composition of individuals that are experienced with pig production, swine biomedical models, operate successful labs that routinely test cutting-edge genome editing technology, and are associated with world-renowned National Swine Resource and Research Center (NSRRC) and the sunsetting Swine Somatic Cell Genome Editing Consortium Large Animal Testing Center.
Awardee
Funding Goals
THE OFFICE OF RESEARCH INFRASTRUCTURE PROGRAMS (ORIP) IS A PROGRAM OFFICE IN THE DIVISION OF PROGRAM COORDINATION, PLANNING, AND STRATEGIC INITIATIVES (DPCPSI) DEDICATED TO SUPPORTING RESEARCH INFRASTRUCTURE AND RELATED RESEARCH RESOURCE PROGRAMS. ORIP CONSISTS OF THE DIVISION OF COMPARATIVE MEDICINE (DCM) AND THE DIVISION OF CONSTRUCTION AND INSTRUMENTS (DCI).
Grant Program (CFDA)
Awarding Agency
Place of Performance
Columbia,
Missouri
652112005
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 200% from $1,329,796 to $3,988,332.
University Of Missouri System was awarded
Swine Genome Editing Services for Biomedical Research
Cooperative Agreement U42OD035738
worth $3,988,332
from the National Institute of Allergy and Infectious Diseases in September 2023 with work to be completed primarily in Columbia Missouri United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.351 Research Infrastructure Programs.
The Cooperative Agreement was awarded through grant opportunity Testing Centers for Development of Somatic Cell Genome Editing in Model Organisms (U42) (Clinical Trials Not Allowed).
Status
(Ongoing)
Last Modified 8/20/25
Period of Performance
9/12/23
Start Date
8/31/28
End Date
Funding Split
$4.0M
Federal Obligation
$0.0
Non-Federal Obligation
$4.0M
Total Obligated
Activity Timeline
Transaction History
Modifications to U42OD035738
Additional Detail
Award ID FAIN
U42OD035738
SAI Number
U42OD035738-1075750904
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75AGNA NIH AGGREGATE FINANCIAL ASSISTANCE DATA AWARDING OFFICE
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
SZPJL5ZRCLF4
Awardee CAGE
9C156
Performance District
MO-03
Senators
Joshua Hawley
Eric Schmitt
Eric Schmitt
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Office of the Director, National Institutes of Health, Health and Human Services (075-0846) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,329,796 | 100% |
Modified: 8/20/25