U24TR005126
Cooperative Agreement
Overview
Grant Description
Tissue Procurement Center (TPC) supporting the Somatic Mosaicism Across Human Tissues (SMAHT) Network - Program Director/Principal Investigator (Bell, Thomas, J.): Project Summary: The Somatic Mosaicism Across Human Tissues (SMAHT) Network project will establish the first comprehensive public resource correlating genetic variation due to somatic mosaicism in human tissues from all developmental layers in the human body.
The SMAHT Network will have multiple centers to support the advancement of three primary initiatives: 1) somatic variant discovery, 2) data analysis and network organization, and 3) technology and tool development. The data from the SMAHT Network project will provide an unparalleled research resource for investigators to gain new insights on genetic variation due to somatic mosaicism processes in healthy human tissues.
In addition to capitalizing on new emerging methodologies to study somatic mosaicism in human tissues, the SMAHT program includes an Ethical, Legal, Social Implications (ELSI) study to further our understanding of the ELSI factors in human tissue donation for somatic mosaicism research. To support the advancement of the SMAHT Network project, this proposal will establish a Tissue Procurement Center (TPC) that will provide the SMAHT Network with multiple, high quality human tissue samples from the same individual across all three developmental layers for their experimental analysis. To meet the challenges for SMAHT Network, our proposal is utilizing a multi-institutional effort with extensive expertise in human tissue collection, research, pathology, imaging, biobanking, and ELSI study analysis.
This span of expertise is essential for the TPC to successfully deliver well-annotated, suitable tissue samples to support the generation of reliable and reproducible results and data interpretations from the SMAHT Network experimental procedures. In addition, the TPC will lead the SMAHT Network ELSI study to shed light on the ELSI-specific factors in human tissue donation for somatic mosaicism research. To enable a more extensive analysis of these factors, the SMAHT Network ELSI study will include evaluations on Tissue Requesters (TRs) and Family Decision Makers (FDMs).
Collectively, our TPC team is committed to establishing an unequaled TPC for the SMAHT Network program to support the advancement of somatic mosaicism research, the associated ELSI factors, and ultimately the development of new clinical approaches to treat disorders driven by genetic variations from somatic mosaicism in human tissues.
Relevance: The Somatic Mosaicism Across Human Tissues (SMAHT) Network project will provide the first comprehensive public resource of analyzing genetic variation due to somatic mosaicism in human tissues from all three developmental layers. The SMAHT Network program will create a new, state-of-the-art research resource to support new discoveries in the biology and disease mechanisms that are propelled by somatic genomic alterations in human tissues and facilitate the development of new clinical approaches for disorders derived from somatic genetic variations. OMB No. 0925-0001/0002 (Rev. 03/2020 approved through 02/28/2023) Page Continuation Format Page
The SMAHT Network will have multiple centers to support the advancement of three primary initiatives: 1) somatic variant discovery, 2) data analysis and network organization, and 3) technology and tool development. The data from the SMAHT Network project will provide an unparalleled research resource for investigators to gain new insights on genetic variation due to somatic mosaicism processes in healthy human tissues.
In addition to capitalizing on new emerging methodologies to study somatic mosaicism in human tissues, the SMAHT program includes an Ethical, Legal, Social Implications (ELSI) study to further our understanding of the ELSI factors in human tissue donation for somatic mosaicism research. To support the advancement of the SMAHT Network project, this proposal will establish a Tissue Procurement Center (TPC) that will provide the SMAHT Network with multiple, high quality human tissue samples from the same individual across all three developmental layers for their experimental analysis. To meet the challenges for SMAHT Network, our proposal is utilizing a multi-institutional effort with extensive expertise in human tissue collection, research, pathology, imaging, biobanking, and ELSI study analysis.
This span of expertise is essential for the TPC to successfully deliver well-annotated, suitable tissue samples to support the generation of reliable and reproducible results and data interpretations from the SMAHT Network experimental procedures. In addition, the TPC will lead the SMAHT Network ELSI study to shed light on the ELSI-specific factors in human tissue donation for somatic mosaicism research. To enable a more extensive analysis of these factors, the SMAHT Network ELSI study will include evaluations on Tissue Requesters (TRs) and Family Decision Makers (FDMs).
Collectively, our TPC team is committed to establishing an unequaled TPC for the SMAHT Network program to support the advancement of somatic mosaicism research, the associated ELSI factors, and ultimately the development of new clinical approaches to treat disorders driven by genetic variations from somatic mosaicism in human tissues.
Relevance: The Somatic Mosaicism Across Human Tissues (SMAHT) Network project will provide the first comprehensive public resource of analyzing genetic variation due to somatic mosaicism in human tissues from all three developmental layers. The SMAHT Network program will create a new, state-of-the-art research resource to support new discoveries in the biology and disease mechanisms that are propelled by somatic genomic alterations in human tissues and facilitate the development of new clinical approaches for disorders derived from somatic genetic variations. OMB No. 0925-0001/0002 (Rev. 03/2020 approved through 02/28/2023) Page Continuation Format Page
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Place of Performance
Philadelphia,
Pennsylvania
191021325
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 90% from $2,999,999 to $5,698,122.
National Disease Research Interchange was awarded
SMAHT Network Tissue Procurement Center: Advancing Somatic Mosaicism Research
Cooperative Agreement U24TR005126
worth $5,698,122
from the National Institute of Allergy and Infectious Diseases in May 2023 with work to be completed primarily in Philadelphia Pennsylvania United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.310 Trans-NIH Research Support.
The Cooperative Agreement was awarded through grant opportunity Somatic Mosaicism across Human Tissues (SMaHT) Program: Tissue Procurement Center (U24 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 7/3/25
Period of Performance
5/1/23
Start Date
4/30/28
End Date
Funding Split
$5.7M
Federal Obligation
$0.0
Non-Federal Obligation
$5.7M
Total Obligated
Activity Timeline
Transaction History
Modifications to U24TR005126
Additional Detail
Award ID FAIN
U24TR005126
SAI Number
U24TR005126-2782732494
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Nonprofit With 501(c)(3) IRS Status (Other Than An Institution Of Higher Education)
Awarding Office
75NR00 NIH National Center for Advancing Translational Sciences
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
F696R1G6DN85
Awardee CAGE
1Q631
Performance District
PA-03
Senators
Robert Casey
John Fetterman
John Fetterman
Modified: 7/3/25