U24HL168712
Cooperative Agreement
Overview
Grant Description
Translational Coordination and Dissemination Center for the SCGE Consortium - Project Summary
The goal of the NIH Common Fund's Somatic Cell Genome Editing (SCGE) program is to take advances in technologies aimed at genome editing and delivery system approaches to correct disease-causing mutations developed in Phase I and translate these efforts into the clinic during Phase II.
The SCGE Translational Coordination and Dissemination Center (TCDC) at the Medical College of Wisconsin (MCW) will continue the efforts of the Phase I SCGE Dissemination and Coordinating Center, acting as the hub to support the three lab and clinical trials-based initiatives in a coordinated effort to facilitate the dissemination of protocols, best practices, SCGE results, and develop a network of collaboration.
The SCGE TCDC at MCW brings a team of experienced investigators, platforms for effective communication and tracking of deliverables and milestones, and demonstrated success in strategic collaborations within the consortium. The overall goal for the SCGE TCDC is to support the SCGE consortium and work cooperatively with all initiatives, projects, and members to facilitate the objectives of the entire SCGE consortium.
To accomplish this, the MCW TCDC will:
1) Build upon and extend the current communication platforms to facilitate communication among participants.
2) Develop the infrastructure to collect, digest, annotate, integrate, and distribute data and resources generated within the SCGE consortium.
3) Create a robust platform for collaboration within the SCGE consortium and with outside partners.
The MCW TCDC will create the infrastructure to develop policies, track progress within the consortium, communicate within and beyond the consortium, and develop outreach and educational activities to support the process of moving pre-clinical studies through the regulatory process, into clinical trials, and eventually to the patient.
To disseminate data and resources developed within the SCGE consortium, the SCGE platform will be assembled to store, query, visualize, and analyze the outcomes of the SCGE initiatives.
The MCW TCDC team will facilitate the administrative and management activities to support the overall success of the program.
The goal of the NIH Common Fund's Somatic Cell Genome Editing (SCGE) program is to take advances in technologies aimed at genome editing and delivery system approaches to correct disease-causing mutations developed in Phase I and translate these efforts into the clinic during Phase II.
The SCGE Translational Coordination and Dissemination Center (TCDC) at the Medical College of Wisconsin (MCW) will continue the efforts of the Phase I SCGE Dissemination and Coordinating Center, acting as the hub to support the three lab and clinical trials-based initiatives in a coordinated effort to facilitate the dissemination of protocols, best practices, SCGE results, and develop a network of collaboration.
The SCGE TCDC at MCW brings a team of experienced investigators, platforms for effective communication and tracking of deliverables and milestones, and demonstrated success in strategic collaborations within the consortium. The overall goal for the SCGE TCDC is to support the SCGE consortium and work cooperatively with all initiatives, projects, and members to facilitate the objectives of the entire SCGE consortium.
To accomplish this, the MCW TCDC will:
1) Build upon and extend the current communication platforms to facilitate communication among participants.
2) Develop the infrastructure to collect, digest, annotate, integrate, and distribute data and resources generated within the SCGE consortium.
3) Create a robust platform for collaboration within the SCGE consortium and with outside partners.
The MCW TCDC will create the infrastructure to develop policies, track progress within the consortium, communicate within and beyond the consortium, and develop outreach and educational activities to support the process of moving pre-clinical studies through the regulatory process, into clinical trials, and eventually to the patient.
To disseminate data and resources developed within the SCGE consortium, the SCGE platform will be assembled to store, query, visualize, and analyze the outcomes of the SCGE initiatives.
The MCW TCDC team will facilitate the administrative and management activities to support the overall success of the program.
Awardee
Funding Goals
THE DIVISION OF LUNG DISEASES SUPPORTS RESEARCH AND RESEARCH TRAINING ON THE CAUSES, DIAGNOSIS, PREVENTION, AND TREATMENT OF LUNG DISEASES AND SLEEP DISORDERS. RESEARCH IS FUNDED THROUGH INVESTIGATOR-INITIATED AND INSTITUTE-INITIATED GRANT PROGRAMS AND THROUGH CONTRACT PROGRAMS IN AREAS INCLUDING ASTHMA, BRONCHOPULMONARY DYSPLASIA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, CYSTIC FIBROSIS, RESPIRATORY NEUROBIOLOGY, SLEEP AND CIRCADIAN BIOLOGY, SLEEP-DISORDERED BREATHING, CRITICAL CARE AND ACUTE LUNG INJURY, DEVELOPMENTAL BIOLOGY AND PEDIATRIC PULMONARY DISEASES, IMMUNOLOGIC AND FIBROTIC PULMONARY DISEASE, RARE LUNG DISORDERS, PULMONARY VASCULAR DISEASE, AND PULMONARY COMPLICATIONS OF AIDS AND TUBERCULOSIS. THE DIVISION IS RESPONSIBLE FOR MONITORING THE LATEST RESEARCH DEVELOPMENTS IN THE EXTRAMURAL SCIENTIFIC COMMUNITY AS WELL AS IDENTIFYING RESEARCH GAPS AND NEEDS, OBTAINING ADVICE FROM EXPERTS IN THE FIELD, AND IMPLEMENTING PROGRAMS TO ADDRESS NEW OPPORTUNITIES. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, USE SMALL BUSINESS TO MEET FEDERAL RESEARCH AND DEVELOPMENT NEEDS, FOSTER AND ENCOURAGE PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY SOCIALLY AND ECONOMICALLY DISADVANTAGED PERSONS, AND INCREASE PRIVATE-SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE TECHNOLOGICAL INNOVATION, FOSTER TECHNOLOGY TRANSFER THROUGH COOPERATIVE R&D BETWEEN SMALL BUSINESSES AND RESEARCH INSTITUTIONS, AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL R&D.
Grant Program (CFDA)
Awarding Agency
Place of Performance
Milwaukee,
Wisconsin
53226
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 272% from $1,302,562 to $4,846,790.
The Medical College Of Wisconsin was awarded
Translational Coordination and Dissemination Center for the SCGE Consortium
Cooperative Agreement U24HL168712
worth $4,846,790
from the National Institute of Allergy and Infectious Diseases in June 2023 with work to be completed primarily in Milwaukee Wisconsin United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.310 Trans-NIH Research Support.
The Cooperative Agreement was awarded through grant opportunity Somatic Cell Genome Editing Program Translational Coordination and Dissemination Center (TCDC) (U24 - Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 6/20/25
Period of Performance
6/1/23
Start Date
5/31/28
End Date
Funding Split
$4.8M
Federal Obligation
$0.0
Non-Federal Obligation
$4.8M
Total Obligated
Activity Timeline
Transaction History
Modifications to U24HL168712
Additional Detail
Award ID FAIN
U24HL168712
SAI Number
U24HL168712-904818254
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Private Institution Of Higher Education
Awarding Office
75NH00 NIH National Heart, Lung, and Blood Institute
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
E8VWJXMMUQ67
Awardee CAGE
4B829
Performance District
WI-04
Senators
Tammy Baldwin
Ron Johnson
Ron Johnson
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Office of the Director, National Institutes of Health, Health and Human Services (075-0846) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,342,562 | 100% |
Modified: 6/20/25