U24HG013233
Cooperative Agreement
Overview
Grant Description
Anvil Clinical Environment for Innovation and Translation (ACE-IT) - Project Summary
The Analysis, Visualization, and Informatics Lab-Space (ANVIL) platform is a scalable cloud-based computing resource that aims to accelerate genomics research by providing broad access to genomics datasets and the infrastructure necessary to improve analysis workflows and enhance collaboration.
The ANVIL Clinical Environment for Innovation and Translation (ACE-IT) project will bring together a network of expertise to address a major gap in clinical genomics research and operationalize a key mission of the ANVIL project by expanding its existing ecosystem to include a comprehensive suite of clinical genomics research tools and services.
The newly developed ANVIL Clinical resource will bring together data, tools, and support resources meant to amplify the benefits of the existing platform and provide a critical foundation for the clinical genomics research community to better leverage this innovative resource.
Development of the ACE-IT will be guided by three key aims:
1. Engagement with diverse community and research partners to characterize barriers and facilitators to adopting federally-supported, cloud-connected clinical genomics research services;
2. Development and deployment approaches to ingest, index, and search data to support clinical genomics research with an emphasis on populations historically underrepresented in biomedical research; and
3. Integration of tools, APIs, and workflows that enable clinical genomics research methods on the ANVIL, including rare disease diagnosis and genomic risk scores as use cases.
The ACE-IT team consists of expertise across multiple health care centers, including Vanderbilt University Medical Center, Brigham and Women's Hospital, Massachusetts General Hospital, and the American Heart Association. This team will develop infrastructure on ANVIL's cloud environment to meet clinical genomics researchers' needs over time and integrate with existing ANVIL working groups and meetings as team members and stakeholders where appropriate.
The tools and resources we develop will support clinical genomics research by focusing on both rare and common diseases and integration into translational research.
The Analysis, Visualization, and Informatics Lab-Space (ANVIL) platform is a scalable cloud-based computing resource that aims to accelerate genomics research by providing broad access to genomics datasets and the infrastructure necessary to improve analysis workflows and enhance collaboration.
The ANVIL Clinical Environment for Innovation and Translation (ACE-IT) project will bring together a network of expertise to address a major gap in clinical genomics research and operationalize a key mission of the ANVIL project by expanding its existing ecosystem to include a comprehensive suite of clinical genomics research tools and services.
The newly developed ANVIL Clinical resource will bring together data, tools, and support resources meant to amplify the benefits of the existing platform and provide a critical foundation for the clinical genomics research community to better leverage this innovative resource.
Development of the ACE-IT will be guided by three key aims:
1. Engagement with diverse community and research partners to characterize barriers and facilitators to adopting federally-supported, cloud-connected clinical genomics research services;
2. Development and deployment approaches to ingest, index, and search data to support clinical genomics research with an emphasis on populations historically underrepresented in biomedical research; and
3. Integration of tools, APIs, and workflows that enable clinical genomics research methods on the ANVIL, including rare disease diagnosis and genomic risk scores as use cases.
The ACE-IT team consists of expertise across multiple health care centers, including Vanderbilt University Medical Center, Brigham and Women's Hospital, Massachusetts General Hospital, and the American Heart Association. This team will develop infrastructure on ANVIL's cloud environment to meet clinical genomics researchers' needs over time and integrate with existing ANVIL working groups and meetings as team members and stakeholders where appropriate.
The tools and resources we develop will support clinical genomics research by focusing on both rare and common diseases and integration into translational research.
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Nashville,
Tennessee
37203
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 106% from $1,494,387 to $3,083,683.
Vanderbilt University Medical Center was awarded
ACE-IT: Accelerating Clinical Genomics Research with ANVIL Platform
Cooperative Agreement U24HG013233
worth $3,083,683
from National Human Genome Research Institute in August 2023 with work to be completed primarily in Nashville Tennessee United States.
The grant
has a duration of 4 years 9 months and
was awarded through assistance program 93.172 Human Genome Research.
The Cooperative Agreement was awarded through grant opportunity The NHGRI Genomic Data Science Analysis, Visualization, and Informatics Lab-space Clinical Resource (ACR) (U24 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 6/5/24
Period of Performance
8/21/23
Start Date
5/31/28
End Date
Funding Split
$3.1M
Federal Obligation
$0.0
Non-Federal Obligation
$3.1M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for U24HG013233
Transaction History
Modifications to U24HG013233
Additional Detail
Award ID FAIN
U24HG013233
SAI Number
U24HG013233-3979499240
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Nonprofit With 501(c)(3) IRS Status (Other Than An Institution Of Higher Education)
Awarding Office
75N400 NIH NATIONAL HUMAN GENOME RESEARCH INSTITUTE
Funding Office
75N400 NIH NATIONAL HUMAN GENOME RESEARCH INSTITUTE
Awardee UEI
GYLUH9UXHDX5
Awardee CAGE
7HUA5
Performance District
TN-05
Senators
Marsha Blackburn
Bill Hagerty
Bill Hagerty
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Human Genome Research Institute, National Institutes of Health, Health and Human Services (075-0891) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,494,387 | 100% |
Modified: 6/5/24