U24HG006620

Democratization of Data Analysis in Life Sciences through Galaxy - Project Summary

For over a decade, the Galaxy Project (https://galaxyproject.org/) has worked to solve key issues plaguing modern data intensive biology. These issues include the ability of researchers to access cutting-edge analysis methods, to share analysis results transparently, and to precisely reproduce complex computational analyses. Galaxy has become one of the largest and most widely used open source platforms for biological data science.

Promoting openness and collaboration in all facets of the project, from technical decisions to training and leadership, has enabled us to build a vibrant community of users, developers, system engineers, and educators. This community continuously contributes new software features, adds the latest tools, adopts the most modern infrastructure, authors training materials, and leads research and training workshops.

Genomics research is continuously evolving, and current challenges include the rapid growth in size and complexity of new datasets, the increasing availability of controlled-access datasets with human genomic components, and the continuing expansion in the breadth of research areas capable of generating high throughput data.

The core Galaxy development team submitting this proposal will respond to these challenges by focusing on the following key priorities:

1. Re-architect Galaxy for scalability and security using software container technologies.
2. Design a new user interface (UI) for working with thousands of tools, workflows, and samples.
3. Enable interactive exploratory data analysis in Galaxy.
4. Facilitate community growth and support.
5. Enable effective training and outreach.

Concentrating on these broad priorities will allow us to achieve the ultimate goal of the Galaxy Project: developing a data analysis medium connecting biomedical experts across the full spectrum of skill sets, scientific domains, and research practices.

For biomedical researchers, Galaxy will provide a powerful analysis platform populated with the latest tools and data. For tool developers, it will provide a community-supported mechanism for deploying tools before a wide audience of users. For system administrators and engineers, it will provide a framework they will feel comfortable deploying on any infrastructure. For educators, it will provide a comprehensive collection of materials covering most data analysis needs and an infrastructure for delivering interactive, hands-on training workshops for audiences of different sizes.

The Pennsylvania State University

NHGRI SUPPORTS THE DEVELOPMENT OF RESOURCES AND TECHNOLOGIES THAT WILL ACCELERATE GENOME RESEARCH AND ITS APPLICATION TO HUMAN HEALTH AND GENOMIC MEDICINE. A CRITICAL PART OF THE NHGRI MISSION CONTINUES TO BE THE STUDY OF THE ETHICAL, LEGAL AND SOCIAL IMPLICATIONS (ELSI) OF GENOME RESEARCH. NHGRI ALSO SUPPORTS THE TRAINING AND CAREER DEVELOPMENT OF INVESTIGATORS AND THE DISSEMINATION OF GENOME INFORMATION TO THE PUBLIC AND TO HEALTH PROFESSIONALS. THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM IS USED TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM IS USED TO FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.172 - Human Genome Research

National Human Genome Research Institute (NHGRI) [HHS - NIH]

University Park, Pennsylvania 16802 United States

Single Zip Code

Genomic Community Resources (U24) (PAR-17-273)

Amendment Since initial award the total obligations have increased 347% from $1,910,000 to $8,539,654.