U24HG001315

Genomic Resource for the Yeast Saccharomyces - Project Summary/Abstract

The Saccharomyces Genome Database (SGD) is the comprehensive resource providing the highest quality reference information about the genome, and its elements, of the budding yeast, Saccharomyces cerevisiae. Saccharomyces cerevisiae provides fundamental knowledge about eukaryotic genetics, genome maintenance and regulation, and a variety of cellular processes.

SGD provides a comprehensive resource that facilitates experimentation in biological systems, and S. cerevisiae informs genetic medicine via annotation of human disease-related phenotypes and gene function through functional complementation between yeast and human homologs. S. cerevisiae is the most well-studied eukaryote, and the experimental literature for this yeast contains these results.

SGD synergizes results from a large variety of molecular and biochemical assays, extending this information by assimilating the results of large-scale genomics assays. It provides connections to fungal species and model eukaryotes via orthology and incorporates formalized and controlled vocabularies to represent biological concepts.

SGD maintains and broadens relationships with the greater scientific community and makes technical improvements through the development of tools and the use of third-party software that enhances the work of scientists and educators. SGD is a founding member of both the Gene Ontology Consortium and the Alliance for Genome Resources and also collaborates with many components of the NCBI and EBI.

SGD provides a substantial service organization and maintains this service to the scientific community, reaching out to scientists in the greater biomedical research community to serve those who have a need for genetic information that can be provided via the synergized results on yeast genes, their products, and their functions.

The Leland Stanford Junior University

NHGRI SUPPORTS THE DEVELOPMENT OF RESOURCES AND TECHNOLOGIES THAT WILL ACCELERATE GENOME RESEARCH AND ITS APPLICATION TO HUMAN HEALTH AND GENOMIC MEDICINE. A CRITICAL PART OF THE NHGRI MISSION CONTINUES TO BE THE STUDY OF THE ETHICAL, LEGAL AND SOCIAL IMPLICATIONS (ELSI) OF GENOME RESEARCH. NHGRI ALSO SUPPORTS THE TRAINING AND CAREER DEVELOPMENT OF INVESTIGATORS AND THE DISSEMINATION OF GENOME INFORMATION TO THE PUBLIC AND TO HEALTH PROFESSIONALS. THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM IS USED TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM IS USED TO FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.172 - Human Genome Research

National Human Genome Research Institute (NHGRI) [HHS - NIH]

Palo Alto, California 94304 United States

Single Zip Code

Genomic Community Resources (U24) (PAR-17-273)

Amendment Since initial award the total obligations have increased 297% from $1,851,854 to $7,356,796.