U24DA057612

WF DISC: Navigating Data Solutions for Chronic Pain and Opioid Use Disorder - Project Summary

The multidimensional challenge of opioid overdose prevention requires solutions larger than a single network project. While the HHS and NIH are focusing on developing prevention strategies from numerous perspectives, blending these data will require complex data solutions to move beyond siloes.

While we do not know yet how bringing the elements of opioid overdose data together will be most effective, collecting these data in ways that allow for FAIR (Findable, Accessible, Interoperable, Reusable) formatting builds toward that potential. The goal of the HEAL D2A program is to develop opioid overdose surveillance in real time, but it is going to take significant combined clinical and informatics knowledge to bring this system together.

To accomplish this goal, our proposal is responsive to RFA-DA-22-052 to design flexible and creative informatics solutions for the HEAL Data2Action Program (HD2A) network. The WF Data Infrastructure Support Center (DISC)'s highly qualified clinical informatics team will provide direct support, guidance, and assistance to ensure that data infrastructures of the highest quality are produced in the shortest possible time for the HEAL D2A innovation projects.

Our overall goal as a U24 data center is to identify and eliminate data infrastructure barriers (knowledge and technical) to allow successful completion of the HD2A projects. The objective of this proposal is to navigate the expected and unexpected data challenges for the HD2A network, encompassing the innovation projects to identify tools, provide data support, and deliver training assistance. We will accomplish this objective through successful completion of these phased aims.

To support the overall hypothesis of the HEAL D2A network, in Aim 1, the WF DISC's Study Start-Up Core will identify and develop data infrastructure support and tools. In Aim 2, WF DISC's Study Conduct Core will work with the HD2A RASC and MERC to provide data measurement, analytical, and visualization support and coordination. In Aim 3, the WF DISC's Study Dissemination Core will develop and provide data training and resources. In Aim 4, we will identify rapid data infrastructure modernization support (Rapid DIMS) needs and provide programmatic resources.

At the successful completion of the proposed research, the expected outcomes are centralized support, resources, and coordination of all data-related needs for the HEAL HD2A innovation projects. The proposed research is innovative because adaptation of our team's experience will bridge clinical research and informatics infrastructure to provide logistical, scientific, oversight, and technical support for data collection, curation, reporting, and management by the HD2A innovation projects.

These results will provide a strong basis for further/future development of opioid overdose prevention surveillance, which is expected to have a significant impact on overdose by allowing for rapid intervention and pivoting of resources. This research aligns with NIH NIDA and HEAL's goals to prevent and mitigate the impact of the OUD epidemic.

Wake Forest University Health Sciences

TO SUPPORT BASIC AND CLINICAL NEUROSCIENCE, BIOMEDICAL, BEHAVIORAL AND SOCIAL SCIENCE, EPIDEMIOLOGIC, HEALTH SERVICES AND HEALTH DISPARITY RESEARCH. TO DEVELOP NEW KNOWLEDGE AND APPROACHES RELATED TO THE PREVENTION, DIAGNOSIS, TREATMENT, ETIOLOGY, AND CONSEQUENCES OF DRUG ABUSE AND ADDICTION, INCLUDING HIV/AIDS. TO SUPPORT RESEARCH TRAINING AND RESEARCH SCIENTIST DEVELOPMENT. TO SUPPORT DISSEMINATION OF RESEARCH FINDINGS. SMALL BUSINESS INNOVATION RESEARCH (SBIR) LEGISLATION IS INTENDED TO EXPAND AND IMPROVE THE SBIR PROGRAMS TO EMPHASIZE AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF TECHNOLOGY DEVELOPED THROUGH FEDERAL SBIR RESEARCH AND DEVELOPMENT, INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN THE SBIR PROGRAM. THE LEGISLATION INTENDS THAT THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.279 - Drug Abuse and Addiction Research Programs

National Institute on Drug Abuse (NIDA) [HHS - NIH]

Winston Salem, North Carolina 27157 United States

Single Zip Code

HEAL Initiative: HEAL Data2Action (HD2A) Data Infrastructure Support Center (U24 Clinical Trial Optional) (RFA-DA-22-052)

Amendment Since initial award the End Date has been extended from 08/31/27 to 08/31/28 and the total obligations have increased 180% from $1,549,997 to $4,339,941.