U24CA268108
Cooperative Agreement
Overview
Grant Description
Cellular Senescence Network (SENNET) Consortium Organization and Data Coordinating Center (CODCC) - Abstract
The Cellular Senescence Network Consortium (SENNET) presents unique new requirements and opportunities for organization and data coordination relative to the rapidly growing community of single-cell genomics mapping consortia, including the Human Biomolecular Atlas Program Consortium (HUBMAP), the Human Cell Atlas (HCA), and the Human Tumor Atlas Network (HTAN).
In particular, SENNET focuses on the discovery, induction, and mapping of specific physiology at the cellular and molecular level under a variety of normal, experimental, and disease conditions. It aims to go beyond just providing a catalog of normal, murine, or cancer tissues. This substantially increases the value of engagement and collaboration among the teams that constitute SENNET.
Specifically, investigators among the Consortium Organization and Data Coordination Center (CODCC), Tissue Management Centers (TMCS), and Technology Development (TTDS), as well as the broader community of cellular senescence (CS) scientists and innovators, will need to work together towards a common purpose to achieve a multiyear strategy of human impact. SENNET will also need senescent cells to cooperate to reveal their biology. These are an understudied set of cells and phenotypes that are fluid in many ways we do not yet understand but may have a profound impact on our ability to address a variety of conditions with a tremendous burden of disease across organ systems (e.g., neurological deterioration, cancer control, and even aging).
SENNET, distinct from other single-cell genomics consortia, will need more shared focus upon prioritizing experiments jointly performed and/or replicated among laboratories. It will prioritize a tight focus on specific cells and address changes, pathways, and trajectories cells may take over time. SENNET will ultimately require changing the conception of single-cell -omics maps to include dynamics in time, space, and function, and will feed these back onto the other efforts.
The Cellular Senescence Network Consortium (SENNET) presents unique new requirements and opportunities for organization and data coordination relative to the rapidly growing community of single-cell genomics mapping consortia, including the Human Biomolecular Atlas Program Consortium (HUBMAP), the Human Cell Atlas (HCA), and the Human Tumor Atlas Network (HTAN).
In particular, SENNET focuses on the discovery, induction, and mapping of specific physiology at the cellular and molecular level under a variety of normal, experimental, and disease conditions. It aims to go beyond just providing a catalog of normal, murine, or cancer tissues. This substantially increases the value of engagement and collaboration among the teams that constitute SENNET.
Specifically, investigators among the Consortium Organization and Data Coordination Center (CODCC), Tissue Management Centers (TMCS), and Technology Development (TTDS), as well as the broader community of cellular senescence (CS) scientists and innovators, will need to work together towards a common purpose to achieve a multiyear strategy of human impact. SENNET will also need senescent cells to cooperate to reveal their biology. These are an understudied set of cells and phenotypes that are fluid in many ways we do not yet understand but may have a profound impact on our ability to address a variety of conditions with a tremendous burden of disease across organ systems (e.g., neurological deterioration, cancer control, and even aging).
SENNET, distinct from other single-cell genomics consortia, will need more shared focus upon prioritizing experiments jointly performed and/or replicated among laboratories. It will prioritize a tight focus on specific cells and address changes, pathways, and trajectories cells may take over time. SENNET will ultimately require changing the conception of single-cell -omics maps to include dynamics in time, space, and function, and will feed these back onto the other efforts.
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding Agency
Place of Performance
Pittsburgh,
Pennsylvania
152133203
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 505% from $3,500,000 to $21,174,278.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education was awarded
SENNET Consortium: Mapping Cellular Senescence for Human Impact
Cooperative Agreement U24CA268108
worth $21,174,278
from the National Institute of Allergy and Infectious Diseases in September 2021 with work to be completed primarily in Pittsburgh Pennsylvania United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.310 Trans-NIH Research Support.
The Cooperative Agreement was awarded through grant opportunity Cellular Senescence Network: Consortium Organization and Data Coordinating Center (U24 Clinical Trial Not Allowed).
Status
(Ongoing)
Last Modified 9/26/25
Period of Performance
9/22/21
Start Date
8/31/26
End Date
Funding Split
$21.2M
Federal Obligation
$0.0
Non-Federal Obligation
$21.2M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for U24CA268108
Transaction History
Modifications to U24CA268108
Additional Detail
Award ID FAIN
U24CA268108
SAI Number
U24CA268108-3453548634
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Other
Awarding Office
75NC00 NIH National Cancer Institute
Funding Office
75NA00 NIH OFFICE OF THE DIRECTOR
Awardee UEI
MKAGLD59JRL1
Awardee CAGE
1DQV3
Performance District
PA-12
Senators
Robert Casey
John Fetterman
John Fetterman
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| Office of the Director, National Institutes of Health, Health and Human Services (075-0846) | Health research and training | Grants, subsidies, and contributions (41.0) | $9,443,742 | 100% |
Modified: 9/26/25