U24CA253529
Cooperative Agreement
Overview
Grant Description
Overture: A Multi-Scale Data Platform for Cancer Genomics Research - Project Summary/Abstract
Overture is a collection of modular, open-source software components designed to make the management of big-data genomic projects both easy and more cost-effective. The Overture system promotes fair data sharing of cancer genomic datasets by overcoming the major obstacles in storing, managing, exploring, and distributing massive genome-scale datasets.
In this proposed project, we will implement a turnkey Overture Data Management System (DMS) to provide a complete solution to manage cancer genomic data throughout the data life cycle and to continue lowering the technical barriers faced by researchers in the cancer informatics community.
To extend the capabilities and potential of the Overture DMS, we will establish a new software framework for integration with third-party visualization applications and for data exchange with analysis platforms. This framework will empower the community to continue developing extremely valuable visualization applications for specific research interests and datatypes, and to contribute them as "apps" to be integrated with the Overture DMS.
Over the next five years, we will:
(1) Combine the core set of Overture components into a scalable DMS installation bundle to promote both local and cloud deployment for a range of small to consortia-scale datasets.
(2) Extend the DMS with third-party visualization and analysis tools through a novel software data integration framework.
(3) Enhance data access controls by implementing Global Alliance for Genomics and Health (GA4GH) Passport and Data Use Ontology standards.
(4) Enable federated searching within cancer datasets across different Overture platforms.
(5) Improve outreach and community resources to meet the needs of bioinformaticians, data producers and managers, data scientists, and clinical researchers.
The Overture DMS will be a valuable resource for removing complications of large-scale data management from researchers, allowing the advancement of scientific research by increasing data sharing and discovery.
Overture is a collection of modular, open-source software components designed to make the management of big-data genomic projects both easy and more cost-effective. The Overture system promotes fair data sharing of cancer genomic datasets by overcoming the major obstacles in storing, managing, exploring, and distributing massive genome-scale datasets.
In this proposed project, we will implement a turnkey Overture Data Management System (DMS) to provide a complete solution to manage cancer genomic data throughout the data life cycle and to continue lowering the technical barriers faced by researchers in the cancer informatics community.
To extend the capabilities and potential of the Overture DMS, we will establish a new software framework for integration with third-party visualization applications and for data exchange with analysis platforms. This framework will empower the community to continue developing extremely valuable visualization applications for specific research interests and datatypes, and to contribute them as "apps" to be integrated with the Overture DMS.
Over the next five years, we will:
(1) Combine the core set of Overture components into a scalable DMS installation bundle to promote both local and cloud deployment for a range of small to consortia-scale datasets.
(2) Extend the DMS with third-party visualization and analysis tools through a novel software data integration framework.
(3) Enhance data access controls by implementing Global Alliance for Genomics and Health (GA4GH) Passport and Data Use Ontology standards.
(4) Enable federated searching within cancer datasets across different Overture platforms.
(5) Improve outreach and community resources to meet the needs of bioinformaticians, data producers and managers, data scientists, and clinical researchers.
The Overture DMS will be a valuable resource for removing complications of large-scale data management from researchers, allowing the advancement of scientific research by increasing data sharing and discovery.
Funding Goals
TO PROVIDE FUNDAMENTAL INFORMATION ON THE CAUSE AND NATURE OF CANCER IN PEOPLE, WITH THE EXPECTATION THAT THIS WILL RESULT IN BETTER METHODS OF PREVENTION, DETECTION AND DIAGNOSIS, AND TREATMENT OF NEOPLASTIC DISEASES. CANCER BIOLOGY RESEARCH INCLUDES THE FOLLOWING RESEARCH PROGRAMS: CANCER CELL BIOLOGY, CANCER IMMUNOLOGY, HEMATOLOGY AND ETIOLOGY, DNA AND CHROMOSOMAL ABERRATIONS, TUMOR BIOLOGY AND METASTASIS, AND STRUCTURAL BIOLOGY AND MOLECULAR APPLICATIONS.
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Canada
Geographic Scope
Foreign
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 393% from $534,624 to $2,635,118.
Ontario Institute For Cancer Research Institut Ontarien De Recherche Sur Le Cancer was awarded
Overture: A Multi-Scale Data Platform for Cancer Genomics Research
Cooperative Agreement U24CA253529
worth $2,635,118
from National Cancer Institute in September 2021 with work to be completed primarily in Canada.
The grant
has a duration of 5 years and
was awarded through assistance program 93.396 Cancer Biology Research.
The Cooperative Agreement was awarded through grant opportunity Advanced Development of Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional).
Status
(Ongoing)
Last Modified 9/24/25
Period of Performance
9/9/21
Start Date
8/31/26
End Date
Funding Split
$2.6M
Federal Obligation
$0.0
Non-Federal Obligation
$2.6M
Total Obligated
Activity Timeline
Transaction History
Modifications to U24CA253529
Additional Detail
Award ID FAIN
U24CA253529
SAI Number
U24CA253529-3467517569
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Non-Domestic (Non-U.S.) Entity
Awarding Office
75NC00 NIH National Cancer Institute
Funding Office
75NC00 NIH National Cancer Institute
Awardee UEI
LH6LETZC1CJ5
Awardee CAGE
L8268
Performance District
Not Applicable
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Cancer Institute, National Institutes of Health, Health and Human Services (075-0849) | Health research and training | Grants, subsidies, and contributions (41.0) | $1,052,665 | 100% |
Modified: 9/24/25