U24AG092191

The Include Project Down Syndrome Biorepository (DS-BIOREPOSITORY) - Project Summary.

Individuals with Down syndrome (DS), the condition caused by trisomy 21 (T21), display an increased risk of developing co-occurring conditions such as congenital heart defects, autism spectrum disorders, seizure disorders, autoimmune conditions, and Alzheimer’s disease.

Despite many research efforts, the mechanisms by which T21 causes these effects are yet to be defined.

The clinical presentation of DS is highly heterogeneous, which could be driven by differences in genetic makeup, epigenetic mechanisms, or variations in the pathophysiology of DS revealed in multi-omics signatures.

Furthermore, the impacts of T21 are likely modulated by sex, race/ethnicity, socio-economic status, lifestyle, and cultural background.

Therefore, there is a clear need to develop a research infrastructure that could support a wide range of investigations by a multidisciplinary team of researchers.

Accordingly, we propose to develop a Down Syndrome Biorepository (DS-BIOREPOSITORY) by leveraging the infrastructure and expertise developed through well-established cohort studies of DS: the Human Trisome Project (HTP), the Alzheimer Biomarkers Consortium – Down Syndrome (ABC-DS), and the Down Syndrome Biobank Consortium (DSBC).

In collaboration with other key stakeholders in the DS research community, we will accomplish the following specific aims:

1. Serve as the primary biorepository for biospecimens generated from INCLUDE-funded research.

Building upon the infrastructure and available biospecimens obtained by the HTP, ABC-DS, and DSBC, we will develop a primary biorepository for all DS research funded by the NIH INCLUDE Project including blood-derived biospecimens, oral biospecimens, biopsies, urine, stool, amniotic fluid, cord blood, and post-mortem tissues, including brain tissue.

These efforts will be informed by the proven pan-omics pipelines of the HTP and ABC-DS studies and by decades of collective experience in biobanking for DS research by all team members.

2. Coordinate the implementation of standard processes, protocols, and practices for biospecimen collection.

Building upon the comprehensive catalogs of standard operating procedures developed by the HTP, ABC-DS, and DSBC studies, and in collaboration with other key stakeholders in the community, we will implement common protocols for biospecimen collection and processing across a vast network of research sites.

3. Develop a web-based interface to facilitate the search of publicly accessible biospecimens.

Building upon the first-ever virtual biorepositories for DS research developed by our team members, we will develop a web-based interface to facilitate the identification of biospecimens based on sample type, demographic, and clinical information of participants, as well as existing datasets from the same samples.

Together, these efforts will accelerate the pace of discoveries that benefit people with DS, while creating a high-quality lasting resource for future generations of DS researchers.

The Regents Of The Univ. Of Colorado

TO ENCOURAGE BIOMEDICAL, SOCIAL, AND BEHAVIORAL RESEARCH AND RESEARCH TRAINING DIRECTED TOWARD GREATER UNDERSTANDING OF THE AGING PROCESS AND THE DISEASES, SPECIAL PROBLEMS, AND NEEDS OF PEOPLE AS THEY AGE. THE NATIONAL INSTITUTE ON AGING HAS ESTABLISHED PROGRAMS TO PURSUE THESE GOALS. THE DIVISION OF AGING BIOLOGY EMPHASIZES UNDERSTANDING THE BASIC BIOLOGICAL PROCESSES OF AGING. THE DIVISION OF GERIATRICS AND CLINICAL GERONTOLOGY SUPPORTS RESEARCH TO IMPROVE THE ABILITIES OF HEALTH CARE PRACTITIONERS TO RESPOND TO THE DISEASES AND OTHER CLINICAL PROBLEMS OF OLDER PEOPLE. THE DIVISION OF BEHAVIORAL AND SOCIAL RESEARCH SUPPORTS RESEARCH THAT WILL LEAD TO GREATER UNDERSTANDING OF THE SOCIAL, CULTURAL, ECONOMIC AND PSYCHOLOGICAL FACTORS THAT AFFECT BOTH THE PROCESS OF GROWING OLD AND THE PLACE OF OLDER PEOPLE IN SOCIETY. THE DIVISION OF NEUROSCIENCE FOSTERS RESEARCH CONCERNED WITH THE AGE-RELATED CHANGES IN THE NERVOUS SYSTEM AS WELL AS THE RELATED SENSORY, PERCEPTUAL, AND COGNITIVE PROCESSES ASSOCIATED WITH AGING AND HAS A SPECIAL EMPHASIS ON ALZHEIMER'S DISEASE. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.310 - Trans-NIH Research Support

National Institute on Aging (NIA) [HHS - NIH]

National Institute of Allergy and Infectious Diseases (NIAID) [HHS - NIH]

Aurora, Colorado 800452507 United States

Single Zip Code

Federated Biobanking resource for the Down Syndrome Cohort Study Program (DS-CDP) across the lifespan for the INCLUDE Project (U24 Clinical Trial Not Allowed) (RFA-OD-24-004)

Amendment Since initial award the total obligations have increased 104% from $5,110,455 to $10,436,444.