U24AG087939

The NH Explanatory Trials Network: Supporting transformation by enhancing partnerships (The Next Steps).

The proposed project, Next Steps (Nursing Home Explanatory Clinical Trials: Supporting transformation by enhancing partnerships) Network, creates a national infrastructure that will address systemic barriers to conducting research in nursing homes (NHS).

NHS care for people with serious, complex medical illnesses and are a critical site of care for people with Alzheimer’s disease and related dementias (ADRD).

The proposed infrastructure is needed to identify and overcome the multiple challenges to conducting research in this setting of care, which include navigating regulatory and recruitment challenges for people with ADRD.

The Next Steps Network aims to provide integrated support for investigators to conduct equitable, explanatory trials in nursing homes.

Next Steps will create a collaborative community of NH leaders, staff, residents and care partners, clinicians, and researchers to identify research priorities for the field and develop action plans to address them.

This will be accomplished via project cores including central coordination; recruitment and retention; methods, measures, and data; and projects and training.

Consensus-based best practices for NH clinical trials will be used to create toolkits and research guidance and foster collaborations.

A pilot projects program and research mentorship will create increased national capacity to conduct NH clinical trials.

A key component of this project is the bi-directional collaboration with the Long-Term Care Data Cooperative (LTCDC), which has created integrated datasets for hundreds of thousands of nursing home residents.

The Next Steps Network real world data scholars and pilot grant awardees will utilize the LTCDC for proposed projects.

The development of experiential learning models will provide embedded opportunities for collaboration and learning for researchers in the nursing home setting.

Research and industry/advocacy advisory panels and partner workgroups will represent key viewpoints in nursing home care and inform all aspects of the project.

The project team will focus on disseminating best practices, pilot project findings and hosting annual meetings, presenting at national conferences and convening regional partner meetings to ensure effective dissemination of key findings.

The Next Steps Network will enable researchers from different disciplines to collaborate, with a goal of increasing the number and quality of clinical trials conducted in NHS, including those that focus on prevention, medical therapeutics, behavioral, health services interventions, and the care of special populations including people with ADRD.

Next Steps will create strong linkages between researchers, industry, and other crucial parties, fostering evidence-based innovations on key priorities to optimize resident care and quality of life for those living, supporting loved ones, and working in NHS.

Trustees Of Indiana University

TO ENCOURAGE BIOMEDICAL, SOCIAL, AND BEHAVIORAL RESEARCH AND RESEARCH TRAINING DIRECTED TOWARD GREATER UNDERSTANDING OF THE AGING PROCESS AND THE DISEASES, SPECIAL PROBLEMS, AND NEEDS OF PEOPLE AS THEY AGE. THE NATIONAL INSTITUTE ON AGING HAS ESTABLISHED PROGRAMS TO PURSUE THESE GOALS. THE DIVISION OF AGING BIOLOGY EMPHASIZES UNDERSTANDING THE BASIC BIOLOGICAL PROCESSES OF AGING. THE DIVISION OF GERIATRICS AND CLINICAL GERONTOLOGY SUPPORTS RESEARCH TO IMPROVE THE ABILITIES OF HEALTH CARE PRACTITIONERS TO RESPOND TO THE DISEASES AND OTHER CLINICAL PROBLEMS OF OLDER PEOPLE. THE DIVISION OF BEHAVIORAL AND SOCIAL RESEARCH SUPPORTS RESEARCH THAT WILL LEAD TO GREATER UNDERSTANDING OF THE SOCIAL, CULTURAL, ECONOMIC AND PSYCHOLOGICAL FACTORS THAT AFFECT BOTH THE PROCESS OF GROWING OLD AND THE PLACE OF OLDER PEOPLE IN SOCIETY. THE DIVISION OF NEUROSCIENCE FOSTERS RESEARCH CONCERNED WITH THE AGE-RELATED CHANGES IN THE NERVOUS SYSTEM AS WELL AS THE RELATED SENSORY, PERCEPTUAL, AND COGNITIVE PROCESSES ASSOCIATED WITH AGING AND HAS A SPECIAL EMPHASIS ON ALZHEIMER'S DISEASE. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

Indianapolis, Indiana 462025173 United States

Single Zip Code

Nursing Home EXplanatory Clinical Trials Network (NEXT) (U24 Clinical Trial Required) (RFA-AG-24-016)

Amendment Since initial award the total obligations have increased 100% from $3,130,685 to $6,261,370.