U19HD119901

PEDIATRIC HIV/AIDS COHORT STUDY (PHACS): RESEARCH ON IMMUNE AGING, SEXUAL AND REPRODUCTIVE HEALTH, AND PERINATAL ACQUISITION: ELUCIDATING RELATIONSHIPS IN HIV (RISE) - CUMULATIVE STRESS BURDEN OVER THE LIFE COURSE MAY ELEVATE THE RISK OF COMORBIDITIES, IMMUNE AGING, REPRODUCTIVE AGING, AND ADVERSE REPRODUCTIVE HEALTH OUTCOMES THAT OFTEN AFFECT PEOPLE WITH HIV (PWH), AND ESPECIALLY MEN AND WOMEN WITH PERINATALLY-ACQUIRED HIV (PHIV). THE CONCEPT OF ALLOSTATIC LOAD (AL) REFERS TO BIOLOGICAL RESPONSES TO CHRONIC STRESS, INCLUDING EXPOSURE TO ADVERSE NON-MEDICAL FACTORS. AL MAY EXPLAIN THE DEVELOPMENT OF ACCELERATED AGING AND COMORBIDITIES AMONG PWH, INCLUDING THOSE WITH PHIV, AS WELL AS THE ADVERSE HEALTH CONDITIONS EXPERIENCED BY POPULATIONS WITH EXPOSURE TO CHRONIC STRESS. FEW HIV RESEARCH PROGRAMS HAVE JOINTLY INVESTIGATED DRIVERS OF AGING AND POOR REPRODUCTIVE HEALTH IN YOUNGER PWH, INCLUDING THOSE WITH PHIV, THROUGH AN INTEGRATED APPROACH, APPLYING THE LENS OF CUMULATIVE STRESS (AL) AND NON-MEDICAL FACTORS. WITH THE PHACS RESEARCH ON IMMUNE AGING, SUPPORTING REPRODUCTIVE HEALTH, AND PERINATAL ACQUISITION: ELUCIDATING RELATIONSHIPS IN HIV (RISE) U19 PROGRAM, WE WILL CLOSE THIS GAP THROUGH TWO LINKED PROJECTS (PROJECT 1 – IMMUNE AGING; PROJECT 2 – REPRODUCTIVE HEALTH). THESE CUTTING-EDGE PROJECTS WILL BE SUPPORTED BY TWO CORES (SCIENTIFIC AND ADMINISTRATIVE CORE; DATA MANAGEMENT AND ANALYSIS CORE) TO PROMOTE HIGH-IMPACT SCIENCE THAT IMPROVES THE HEALTH OF PWH ACROSS THE LIFESPAN. AIM 1 OF THE PHACS RISE PROGRAM IS TO ASSEMBLE A PROSPECTIVE COHORT OF OVER 700 MEN AND WOMEN WITH PHIV AND WOMEN PWH (BOTH PHIV AND NON-PHIV [NPHIV]) ACROSS 7 US SITES. AIM 2 IS TO ELUCIDATE PATHWAYS OF CHRONIC STRESS (AS REFLECTED BY AL), IMMUNE AGING, AND COMORBIDITIES IN THE CONTEXT OF HIV, ART, PERINATAL HIV ACQUISITION, AND HIV VIRAL RESERVOIR BURDEN (PROJECT 1). AIM 3 IS TO ELUCIDATE PATHWAYS OF CHRONIC STRESS (AL), ADVERSE PREGNANCY OUTCOMES, REPRODUCTIVE AGING, AND HUMAN PAPILLOMA VIRUS PERSISTENCE IN THE CONTEXT OF HIV, ART, AND PERINATAL HIV ACQUISITION (PROJECT 2). THROUGH A CONSORTIUM OF SEVEN EXPERIENCED U.S.-BASED CLINICAL SITES AND AN EXPERT MULTIDISCIPLINARY TEAM OF INVESTIGATORS, WE WILL BUILD ON YEARS OF NIH INVESTMENT AND FOUNDATIONAL COHORTS IN PHACS. WE HAVE RE-DESIGNED THE PHACS NETWORK TO ESTABLISH A NEW, UNIFIED, AND STREAMLINED PROTOCOL, PHACS RISE. BY LEVERAGING WELL-CURATED EXISTING DATA, COMPREHENSIVELY PHENOTYPED COHORTS OF MEN AND WOMEN WITH PHIV, RICH SPECIMEN REPOSITORIES, AND THE ROBUST RESEARCH INFRASTRUCTURE OF PHACS, WE WILL ADVANCE RESEARCH IN PWH, INCLUDING THOSE WITH PHIV, TOWARDS DISCOVERY OF INSIGHTS AROUND THE DOWNSTREAM REPERCUSSIONS OF MODIFIABLE FACTORS. PHACS RISE AIMS TO BRIDGE GAPS IN KNOWLEDGE AROUND OUR CENTRAL THEME – THE INTERPLAY OF HIV, CHRONIC STRESS, AGING, AND REPRODUCTIVE HEALTH – AND INFORM FUTURE STUDIES AROUND PREVENTION AND POTENTIAL INTERVENTIONS AGAINST HIV AGING-RELATED COMORBIDITES AND ADVERSE REPRODUCTIVE HEALTH.

President And Fellows Of Harvard College

TO CONDUCT AND SUPPORT LABORATORY RESEARCH, CLINICAL TRIALS, AND STUDIES WITH PEOPLE THAT EXPLORE HEALTH PROCESSES. NICHD RESEARCHERS EXAMINE GROWTH AND DEVELOPMENT, BIOLOGIC AND REPRODUCTIVE FUNCTIONS, BEHAVIOR PATTERNS, AND POPULATION DYNAMICS TO PROTECT AND MAINTAIN THE HEALTH OF ALL PEOPLE. TO EXAMINE THE IMPACT OF DISABILITIES, DISEASES, AND DEFECTS ON THE LIVES OF INDIVIDUALS. WITH THIS INFORMATION, THE NICHD HOPES TO RESTORE, INCREASE, AND MAXIMIZE THE CAPABILITIES OF PEOPLE AFFECTED BY DISEASE AND INJURY. TO SPONSOR TRAINING PROGRAMS FOR SCIENTISTS, DOCTORS, AND RESEARCHERS TO ENSURE THAT NICHD RESEARCH CAN CONTINUE. BY TRAINING THESE PROFESSIONALS IN THE LATEST RESEARCH METHODS AND TECHNOLOGIES, THE NICHD WILL BE ABLE TO CONDUCT ITS RESEARCH AND MAKE HEALTH RESEARCH PROGRESS UNTIL ALL CHILDREN, ADULTS, FAMILIES, AND POPULATIONS ENJOY GOOD HEALTH. THE MISSION OF THE NICHD IS TO ENSURE THAT EVERY PERSON IS BORN HEALTHY AND WANTED, THAT WOMEN SUFFER NO HARMFUL EFFECTS FROM REPRODUCTIVE PROCESSES, AND THAT ALL CHILDREN HAVE THE CHANCE TO ACHIEVE THEIR FULL POTENTIAL FOR HEALTHY AND PRODUCTIVE LIVES, FREE FROM DISEASE OR DISABILITY, AND TO ENSURE THE HEALTH, PRODUCTIVITY, INDEPENDENCE, AND WELL-BEING OF ALL PEOPLE THROUGH OPTIMAL REHABILITATION.

93.121 - Oral Diseases and Disorders Research

National Institute of Child Health and Human Development (NICHD) [HHS - NIH]

National Institute of Dental and Craniofacial Research (NIDCR) [HHS - NIH]

Massachusetts United States

State-Wide

Pediatric HIV/AIDS Cohort Study (PHACS) (U19 Clinical Trial Not Allowed) (RFA-HD-25-003)

Amendment Since initial award the total obligations have increased 2619% from $300,000 to $8,158,233.