U19HD118601

RESEARCHING INTERVENTIONS AND IMPLEMENTATION STRATEGIES TO EVALUATE THE HEALTH AND DEVELOPMENT OF CHILDREN AFFECTED BY HIV IN SOUTHERN AND EASTERN AFRICA (RISE) - ABSTRACT OVER THE PAST 5 YEARS, NICHD HAS SUPPORTED IN-DEPTH STUDIES OF CHEU THROUGH AN R61/R33 MECHANISM IN 5 PROGRAMS. WE PROPOSE TO AMPLIFY THE IMPACT OF THE PRIOR AWARDS BY COLLABORATING IN A MULTI-COUNTRY APPLICATION FOCUSED ON CHEU RESEARCH THAT INVOLVES 4 OF THE 5 PRIOR R61/R33 AWARDEES CONDUCTING STUDIES IN HIGH HIV PREVALENCE SETTINGS (BOTSWANA, KENYA, SOUTH AFRICA AND ZIMBABWE). OUR U19 APPLICATION ENTITLED “RESEARCHING INTERVENTIONS AND IMPLEMENTATION STRATEGIES TO EVALUATE THE HEALTH AND DEVELOPMENT OF CHILDREN AFFECTED BY HIV IN SOUTHERN AND EAST AFRICA (RISE)”, HAS THE FOLLOWING AIMS: 1. TO BUILD A U19 STRUCTURE THAT INCLUDES 4 RESEARCH PROJECTS AND 3 CORES AS FOLLOWS: A) PROJECT 1 (NEUROANATOMIC PATHWAYS): USING EXISTING COHORTS, TO COMPARE BRAIN STRUCTURE IN CHEU AND CHU AT 5-10 YEARS AND CHARACTERIZE LONGITUDINAL BRAIN STRUCTURAL CHANGES IN BOTSWANA AND KENYA USING LOW-FIELD AND HIGH-FIELD MRI; AND DETERMINE ASSOCIATIONS BETWEEN BRAIN STRUCTURE AND NEURODEVELOPMENT. COMPARATOR GROUPS INCLUDE CHILDREN AND ADOLESCENTS UNEXPOSED TO HIV (CHU) AND PREP-EXPOSED CHU. B) PROJECT 2 (INTERVENTION): DETERMINE THE IMPACT OF A COMBINATION INTERVENTION (WHICH INCLUDES PSYCHOSOCIAL SUPPORT THROUGH PROBLEM-SOLVING THERAPY [FRIENDSHIP BENCH]; COUNSELING ON OPTIMAL INFANT AND YOUNG CHILD FEEDING; CHILD PLAY/EARLY LEARNING TO SPUR INTERACTION AND LANGUAGE/MOTOR SKILLS) ON NEURODEVELOPMENT IN CHEU AND CHU IN AN INDIVIDUAL RCT ACROSS 3 COUNTRIES. C) PROJECT 3 (IMPLEMENTATION): TO DETERMINE VALIDITY AND FEASIBILITY OF USING A RISK-SCORE TO IDENTIFY AND REFER CHEU AT MOST RISK FOR NEURODEVELOPMENTAL DELAY; EVALUATE ACCEPTABILITY, FEASIBILITY AND COST OF PROJECT 2 INTERVENTIONS; AND TO MODEL COST-EFFECTIVENESS AND IMPACT OF RISK-BASED SCREENING/REFERRAL AND INTERVENTIONS AMONG CHEU AND CHU. D) PROJECT 4 (SURVEILLANCE): EXTEND USE OF LARGE-SCALE PROGRAMMATIC DATA TO ASSESS POPULATION-IMPACT OF IN UTERO AND PERIPARTUM HIV/ARV EXPOSURE (INCLUDING NEWER ARVS) IN THE SOUTH AFRICA CHERISH PROVINCE-WIDE COHORT ON PREGNANCY, INFECTIOUS DISEASE AND OTHER OUTCOMES AND TO ENGAGE MINISTRIES OF HEALTH IN BOTSWANA AND KENYA TO CO-DEVELOP DATA-DRIVEN MODELS FOR LONG-TERM SURVEILLANCE OF CHEU. 2. TO IMPLEMENT A SHARED SCIENTIFIC ADMINISTRATIVE CORE (SAC) TO OVERSEE SCIENTIFIC DIRECTIONS AND IMPLEMENTATION OF THE RESEARCH PROJECTS AND ADMINISTRATIVE, FISCAL, AND COMMUNICATION FOR THE U19. 3. TO IMPLEMENT A SHARED DATA MANAGEMENT AND ANALYSIS CORE (DMAC) TO OVERSEE DATA MANAGEMENT, STANDARDIZATION, QUALITY CONTROL AND ANALYSIS AND TO BUILD CAPACITY FOR IN-COUNTRY DATA ANALYSIS. 4. TO IMPLEMENT A SHARED DISSEMINATION AND ENGAGEMENT CORE (DEC) TO DEVELOP MATERIALS AND ENGAGE STAKEHOLDERS AT COMMUNITY, COUNTY/LOCAL, NATIONAL, AND GLOBAL (WHO, UNICEF) LEVELS IN RISE U19 FINDINGS.

University Of Washington

TO CONDUCT AND SUPPORT LABORATORY RESEARCH, CLINICAL TRIALS, AND STUDIES WITH PEOPLE THAT EXPLORE HEALTH PROCESSES. NICHD RESEARCHERS EXAMINE GROWTH AND DEVELOPMENT, BIOLOGIC AND REPRODUCTIVE FUNCTIONS, BEHAVIOR PATTERNS, AND POPULATION DYNAMICS TO PROTECT AND MAINTAIN THE HEALTH OF ALL PEOPLE. TO EXAMINE THE IMPACT OF DISABILITIES, DISEASES, AND DEFECTS ON THE LIVES OF INDIVIDUALS. WITH THIS INFORMATION, THE NICHD HOPES TO RESTORE, INCREASE, AND MAXIMIZE THE CAPABILITIES OF PEOPLE AFFECTED BY DISEASE AND INJURY. TO SPONSOR TRAINING PROGRAMS FOR SCIENTISTS, DOCTORS, AND RESEARCHERS TO ENSURE THAT NICHD RESEARCH CAN CONTINUE. BY TRAINING THESE PROFESSIONALS IN THE LATEST RESEARCH METHODS AND TECHNOLOGIES, THE NICHD WILL BE ABLE TO CONDUCT ITS RESEARCH AND MAKE HEALTH RESEARCH PROGRESS UNTIL ALL CHILDREN, ADULTS, FAMILIES, AND POPULATIONS ENJOY GOOD HEALTH. THE MISSION OF THE NICHD IS TO ENSURE THAT EVERY PERSON IS BORN HEALTHY AND WANTED, THAT WOMEN SUFFER NO HARMFUL EFFECTS FROM REPRODUCTIVE PROCESSES, AND THAT ALL CHILDREN HAVE THE CHANCE TO ACHIEVE THEIR FULL POTENTIAL FOR HEALTHY AND PRODUCTIVE LIVES, FREE FROM DISEASE OR DISABILITY, AND TO ENSURE THE HEALTH, PRODUCTIVITY, INDEPENDENCE, AND WELL-BEING OF ALL PEOPLE THROUGH OPTIMAL REHABILITATION.

93.865 - Child Health and Human Development Extramural Research

National Institute of Child Health and Human Development (NICHD) [HHS - NIH]

Seattle, Washington 981951016 United States

Single Zip Code

Optimizing Health of Children and Adolescents with Perinatal HIV Exposure (U19 Clinical Trial Optional) (RFA-HD-25-004)

Amendment Since initial award the total obligations have increased 85% from $3,582,653 to $6,635,347.