U19CA291430

Washington University ACCERT Center - Project Summary (Abstract)

Goal: The overall goal of the WASHU ACCERT is to advance cancer control equity through community-engaged multilevel research interventions that address the impact of social determinants of health on adverse cancer control outcomes.

Aims: The specific aims of the center are to:

(1) Bring innovation to cancer control equity research through community-academic partnerships in using multilevel research methods and measures to develop transformative solutions;

(2) Assemble and engage an exceptional, diverse team of cancer health equity investigators and build capacity among academic and community partners;

(3) Organize and integrate center components in a manner that facilitates new thinking about health equity through transdisciplinary, team science;

(4) Develop a research methods, measures and data management shared resource (RMMDM CORE) to support the implementation and dissemination of scientifically rigorous internal and cross center projects;

(5) Identify opportunities and develop plans to effectively address social determinants of health and reduce cancer disparities.

Strategy: WASHU-ACCERT will build on a long record of community engaged research to reduce cancer disparities and sustain mechanisms for community input of responsive research.

This will be accomplished by engaging investigators from different disciplines and investing in the development of community partners and early-stage investigators.

We will build on expertise in community-engaged research, dissemination science, and social determinants of health (SDOH) to deliver responsive products and use ongoing measures of community engagement to monitor and adjust our processes.

By continuously engaging community partners, we will bring meaningful relief through improvements in care, build trust in the research enterprise, and accelerate the elimination of cancer disparities.

Innovation and Impact: Our proposed center will be particularly innovative and have widespread impact by advancing a network of cancer control equity researchers, building intellectual capital, and enhancing the capacity for health equity in cancer prevention and control.

WASHU-ACCERT has distinctive features that build on a sustained focus on cancer disparities and apply strategies to build multilevel interventions that are responsive to community needs.

These features include a uniquely diverse team as part of our community responsive research program (CRRP), engagement and development of community partners and early-stage investigators, strategic dissemination of products to benefit communities, and a focused strategy for collective integration of projects and cores across ACCERT centers.

This center will ultimately advance cancer control equity and promote capacity building among community partners.

Washington University

TO IDENTIFY CANCER RISKS AND RISK REDUCTION STRATEGIES, TO IDENTIFY FACTORS THAT CAUSE CANCER IN HUMANS, AND TO DISCOVER AND DEVELOP MECHANISMS FOR CANCER PREVENTION AND PREVENTIVE INTERVENTIONS IN HUMANS. RESEARCH PROGRAMS INCLUDE: (1) CHEMICAL, PHYSICAL AND MOLECULAR CARCINOGENESIS, (2) SCREENING, EARLY DETECTION AND RISK ASSESSMENT, INCLUDING BIOMARKER DISCOVERY, DEVELOPMENT AND VALIDATION, (3) EPIDEMIOLOGY, (4) NUTRITION AND BIOACTIVE FOOD COMPONENTS, (5) IMMUNOLOGY AND VACCINES, (6) FIELD STUDIES AND STATISTICS, (7) CANCER CHEMOPREVENTION AND INTERCEPTION, (8) PRE-CLINICAL AND CLINICAL AGENT DEVELOPMENT, (9) ORGAN SITE STUDIES AND CLINICAL TRIALS, (10) HEALTH-RELATED QUALITY OF LIFE AND PATIENT-CENTERED OUTCOMES, AND (11) SUPPORTIVE CARE AND MANAGEMENT OF SYMPTOMS AND TOXICITIES. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO STIMULATE TECHNICAL INNOVATION, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY WOMEN AND SOCIALLY/ECONOMICALLY DISADVANTAGED PERSONS. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING, AND FOSTER PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY WOMEN AND SOCIALLY/ECONOMICALLY DISADVANTAGED PERSONS.

93.393 - Cancer Cause and Prevention Research

National Cancer Institute (NCI) [HHS - NIH]

Saint Louis, Missouri 631101010 United States

Single Zip Code

Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) (PA-20-272)

Amendment Since initial award the total obligations have increased 129% from $1,687,583 to $3,859,649.