U19AG066567

Adult Changes in Thought (ACT) Research Program - The Adult Changes in Thought (ACT) U19 program will expand, modernize, and improve ACT's prospective cohort study to achieve advances in scientific understanding of older adults in general and dementia and Alzheimer's disease in particular. ACT is set in a healthcare delivery system. The study team identifies incident cases of dementia and Alzheimer's disease and follows consenting participants to autopsy.

The program will transform the current ACT U01 to a U19, which envisions complex multi-component programs that will have a powerful influence on the field. The program's overarching goal is to identify risk factors across the life course that provide potential intervention targets for preserving cognition and preventing Alzheimer's disease and related dementias (ADRD).

The overall specific aims are:

AIM 1. Expand ACT cohort enrollment and modernize and improve follow-up with emphasis on increasing racial/ethnic diversity and deep phenotyping of life course risk factors, cognitive and physical functioning, and outcomes including neuroimaging and neuropathology based ADRD outcomes. The cores will expand cohort enrollment from 2,000 to 3,000. The study will invest in six cores: A, Administrative; B, Clinical; C, Life Course; D, Neuropathology; E, Neuroimaging; F, Data and Analysis. These cores will work together to further enhance the value of ACT's resources, enabling the ACT study to continue to be the foundation for an extraordinary array of science.

To date, ACT has achieved a completeness of follow-up index of 94.5% and has observed 56,140 person-years of follow-up. ACT has identified >1,300 incident dementia cases and >1,000 incident Alzheimer's cases. The study has completed >850 autopsies and will surpass 1,100 autopsies this cycle. Additionally, 1,077 ACT participants had one MRI scan, and 540 have had =2, with funding in place for hundreds more.

AIM 2. Support key projects studying the spectrum of healthy functioning to ADRD in older adults. The three projects center around 24-hour cycle physical activity, sedentary behavior, and sleep patterns in old age (Project 1), the implications of cognitively defined Alzheimer's disease subgroups (Project 2), and mechanisms underlying neural protection and toxicity of strong anticholinergic drugs and antihypertensive drugs (Project 3).

AIM 3. Expand and improve ACT's dissemination of exceptional resources to the research community guided by NIA's adopted FAIR (Findable, Accessible, Interoperable, and Reproducible) principles. ACT has proven to be an exceptional resource to the research community, providing data and specimens to research colleagues locally, across the country, and around the world, and provides mentorship to junior investigators. We will continue to enhance our data sharing capabilities in this U19 program.

Kaiser Foundation Hospitals

TO ENCOURAGE BIOMEDICAL, SOCIAL, AND BEHAVIORAL RESEARCH AND RESEARCH TRAINING DIRECTED TOWARD GREATER UNDERSTANDING OF THE AGING PROCESS AND THE DISEASES, SPECIAL PROBLEMS, AND NEEDS OF PEOPLE AS THEY AGE. THE NATIONAL INSTITUTE ON AGING HAS ESTABLISHED PROGRAMS TO PURSUE THESE GOALS. THE DIVISION OF AGING BIOLOGY EMPHASIZES UNDERSTANDING THE BASIC BIOLOGICAL PROCESSES OF AGING. THE DIVISION OF GERIATRICS AND CLINICAL GERONTOLOGY SUPPORTS RESEARCH TO IMPROVE THE ABILITIES OF HEALTH CARE PRACTITIONERS TO RESPOND TO THE DISEASES AND OTHER CLINICAL PROBLEMS OF OLDER PEOPLE. THE DIVISION OF BEHAVIORAL AND SOCIAL RESEARCH SUPPORTS RESEARCH THAT WILL LEAD TO GREATER UNDERSTANDING OF THE SOCIAL, CULTURAL, ECONOMIC AND PSYCHOLOGICAL FACTORS THAT AFFECT BOTH THE PROCESS OF GROWING OLD AND THE PLACE OF OLDER PEOPLE IN SOCIETY. THE DIVISION OF NEUROSCIENCE FOSTERS RESEARCH CONCERNED WITH THE AGE-RELATED CHANGES IN THE NERVOUS SYSTEM AS WELL AS THE RELATED SENSORY, PERCEPTUAL, AND COGNITIVE PROCESSES ASSOCIATED WITH AGING AND HAS A SPECIAL EMPHASIS ON ALZHEIMER'S DISEASE. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

Seattle, Washington 981011466 United States

Single Zip Code

Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional) (PAR-19-374)

Amendment Since initial award the total obligations have increased 386% from $11,720,668 to $56,992,346.