U01NS131797
Cooperative Agreement
Overview
Grant Description
Implementation of a Stroke Protocol for Emergency Evaluation and Disposition (I-SPEED) - Project Abstract
Nearly 800,000 people in the United States (US) each year experience acute stroke, which remains the leading cause of adult disability and 5th leading cause of death. Despite the proliferation of stroke centers nationwide, almost half of the US population lives beyond a 60-minute drive of a comprehensive stroke center (CSC) and most patients are initially evaluated at a primary stroke center (PSC).
While a key treatment, alteplase can be delivered at most US hospitals, advanced diagnostics and treatments are only available at CSCs. However, the PSC "door-in-door-out" (DIDO) evaluation process for patients who need to be transferred to a CSC can be time consuming and inefficient, contributing to inability to receive treatment.
Building upon our prior work to reduce PSC DIDO time, this proposal, "Implementation of a Stroke Protocol for Emergency Evaluation and Disposition (I-SPEED)" seeks to (1) implement a novel, evidence-based, multi-component DIDO intervention in eight diverse stroke systems of care across multiple regions of the US and (2) conduct a dual evaluation of its effectiveness in reducing median DIDO time (primary outcome) and disability (secondary outcome) and of the fidelity and quality of implementation.
The I-SPEED study will definitively establish the effectiveness and generalizability of a multi-component evidence-based DIDO intervention and provide information about contextual adaptations for high-quality implementation and widespread dissemination. This study benefits from our well-established interdisciplinary expertise in stroke, emergency and prehospital medicine, systems and quality engineering, health services research, and strong multicenter research collaborations.
Findings from I-SPEED will have substantial implications for a wide range of hospitals and stroke systems of care worldwide.
Nearly 800,000 people in the United States (US) each year experience acute stroke, which remains the leading cause of adult disability and 5th leading cause of death. Despite the proliferation of stroke centers nationwide, almost half of the US population lives beyond a 60-minute drive of a comprehensive stroke center (CSC) and most patients are initially evaluated at a primary stroke center (PSC).
While a key treatment, alteplase can be delivered at most US hospitals, advanced diagnostics and treatments are only available at CSCs. However, the PSC "door-in-door-out" (DIDO) evaluation process for patients who need to be transferred to a CSC can be time consuming and inefficient, contributing to inability to receive treatment.
Building upon our prior work to reduce PSC DIDO time, this proposal, "Implementation of a Stroke Protocol for Emergency Evaluation and Disposition (I-SPEED)" seeks to (1) implement a novel, evidence-based, multi-component DIDO intervention in eight diverse stroke systems of care across multiple regions of the US and (2) conduct a dual evaluation of its effectiveness in reducing median DIDO time (primary outcome) and disability (secondary outcome) and of the fidelity and quality of implementation.
The I-SPEED study will definitively establish the effectiveness and generalizability of a multi-component evidence-based DIDO intervention and provide information about contextual adaptations for high-quality implementation and widespread dissemination. This study benefits from our well-established interdisciplinary expertise in stroke, emergency and prehospital medicine, systems and quality engineering, health services research, and strong multicenter research collaborations.
Findings from I-SPEED will have substantial implications for a wide range of hospitals and stroke systems of care worldwide.
Awardee
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Chicago,
Illinois
606375418
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 254% from $919,872 to $3,258,972.
University Of Chicago was awarded
I-SPEED: Enhancing Stroke Protocol Efficient Evaluation Disposition
Cooperative Agreement U01NS131797
worth $3,258,972
from the National Institute of Neurological Disorders and Stroke in August 2023 with work to be completed primarily in Chicago Illinois United States.
The grant
has a duration of 5 years and
was awarded through assistance program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders.
The Cooperative Agreement was awarded through grant opportunity Dissemination and Implementation Research in Health (R01 Clinical Trial Optional).
Status
(Ongoing)
Last Modified 8/5/26
Period of Performance
8/7/23
Start Date
7/31/28
End Date
Funding Split
$3.3M
Federal Obligation
$0.0
Non-Federal Obligation
$3.3M
Total Obligated
Activity Timeline
Subgrant Awards
Disclosed subgrants for U01NS131797
Transaction History
Modifications to U01NS131797
Additional Detail
Award ID FAIN
U01NS131797
SAI Number
U01NS131797-1787637008
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Private Institution Of Higher Education
Awarding Office
75NQ00 NIH National Institute of Neurological Disorders and Stroke
Funding Office
75NQ00 NIH National Institute of Neurological Disorders and Stroke
Awardee UEI
ZUE9HKT2CLC9
Awardee CAGE
5E688
Performance District
IL-01
Senators
Richard Durbin
Tammy Duckworth
Tammy Duckworth
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Institute of Neurological Disorders and Stroke, National Institutes of Health, Health and Human Services (075-0886) | Health research and training | Grants, subsidies, and contributions (41.0) | $919,872 | 100% |
Modified: 8/5/26