U01DA063534

TOWARD COMPREHENSIVE MODELS OF NATURALISTIC COOPERATION AND COMPETITION IN PRIMATES - PROJECT SUMMARY THE FLEXIBLE ABILITY TO WORK TOGETHER FOR MUTUAL BENEFITS WHILE COMPETING AGAINST OTHERS FOR LIMITED RESOURCES IS A HALLMARK OF ADVANCED SOCIAL COGNITION. COOPERATIVE AND COMPETITIVE INTERACTIONS ARE HIGHLY DYNAMIC AND COMPLEX. HOWEVER, STUDYING THE PRECISE BEHAVIORAL MECHANISMS OF THESE INTERACTIONS HAS BEEN CHALLENGING. THIS IS PARTLY DUE TO THE FACT THAT THE STANDARD ANIMAL MODELS IN LAB STUDIES DO NOT RELIABLY COOPERATE. MOREOVER, TYPICAL STUDIES DO NOT INCLUDE MULTIDIMENSIONAL BEHAVIORAL MEASUREMENTS THAT ARE ESSENTIAL TO UNDERSTAND SUCH COMPLEX INTERACTIONS. THEREFORE, THERE IS A NEED TO INVESTIGATE COMPLEX SOCIAL INTERACTIONS IN A SPECIES WHOSE SOCIAL STRUCTURE STRONGLY DEPENDS ON BOTH COOPERATION AND COMPETITION, WHILE TRACKING MULTIPLE ACTION-BASED AND INTERNAL STATE-RELATED VARIABLES TO OBTAIN A COMPREHENSIVE UNDERSTANDING OF SOCIAL BEHAVIOR. THE MARMOSET IS AN EXCELLENT SPECIES FOR STUDYING COMPLEX SOCIAL INTERACTIONS GROUNDED IN CONTEXT-DEPENDENT COOPERATIVE AND COMPETITIVE TENDENCIES WITHIN THEIR NATURAL ETHOLOGY. THE FIRST MAJOR GOAL OF THIS PROPOSAL IS TO SIMULTANEOUSLY AND CONTINUOUSLY COLLECT MULTIDIMENSIONAL BIOBEHAVIORAL MEASUREMENTS, BOTH ACTION-BASED AND INTERNAL STATE-BASED, DURING NATURALISTIC COOPERATIVE AND COMPETITIVE INTERACTIONS BETWEEN FREELY MOVING MARMOSETS. WE AIM TO UNDERSTAND THE FUNCTIONAL AND DIRECTIONALLY CAUSAL DEPENDENCIES OF THESE BIOBEHAVIORAL VARIABLES IN COOPERATIVE AND COMPETITIVE BEHAVIORS. THE SECOND MAJOR GOAL IS TO BUILD COMPREHENSIVE AND EMPIRICALLY TESTABLE GENERATIVE MODELS OF PRIMATE SOCIAL INTERACTION AND TO VALIDATE OUR UNDERSTANDING ITERATIVELY BETWEEN THE MODELS AND THE EXPERIMENTS. WE WILL USE MULTIPLE MODELING APPROACHES TO EXPLOIT THEIR STRENGTHS: MULTI-AGENT REINFORCEMENT LEARNING WITH RECURRENT NEURAL NETWORKS WILL BE USED TO LEARN COMPLEX PATTERNS FOR PREDICTION, AND THE STRUCTURE AND INPUTS TO THESE MODELS WILL BE INFORMED BY DYNAMIC BAYESIAN NETWORKS TO INCREASE THE INTERPRETABILITY OF THE MODELS. WE WILL USE AN EMBODIED AGENT-BASED FRAMEWORK, WITH THE RECURRENT NEURAL NETWORKS DRIVING MUSCULOSKELETAL MODELS OF MARMOSETS, TO BETTER MODEL COOPERATIVE AND COMPETITIVE INTERACTIONS OF NONHUMAN PRIMATES. WITH THE COMPREHENSIVE BIOBEHAVIORAL DATA AND THE MUSCULOSKELETAL MODEL, WE WILL BUILD GENERALIZABLE MODELS OF PRIMATE SOCIAL INTERACTION VIA A MULTI-LEVEL CONSTRAINTS-BASED FRAMEWORK. FINALLY, WE WILL VALIDATE THE GENERATIVE MODELS OF PRIMATE SOCIAL INTERACTION BY INDUCING MULTIPLE TYPES OF IN SILICO ENVIRONMENTAL AND TASK MANIPULATIONS THAT ARE DESIGNED TO PREDICTABLY ALTER SOCIAL STRATEGIES AND CARRYING OUT THOSE EXPERIMENTS IN VIVO THAT SIGNIFICANTLY ALTER THE RESULTING SOCIAL STRATEGY. OVERALL, WE AIM TO PROVIDE THE MOST COMPREHENSIVE UNDERSTANDING OF PRIMATE SOCIAL INTERACTIONS TO DATE, ALONG WITH NOVEL GENERATIVE MODELS OF SUCH BEHAVIOR.

Yale Univ

TO SUPPORT BASIC AND CLINICAL NEUROSCIENCE, BIOMEDICAL, BEHAVIORAL AND SOCIAL SCIENCE, EPIDEMIOLOGIC, HEALTH SERVICES AND HEALTH DISPARITY RESEARCH. TO DEVELOP NEW KNOWLEDGE AND APPROACHES RELATED TO THE PREVENTION, DIAGNOSIS, TREATMENT, ETIOLOGY, AND CONSEQUENCES OF DRUG ABUSE AND ADDICTION, INCLUDING HIV/AIDS. TO SUPPORT RESEARCH TRAINING AND RESEARCH SCIENTIST DEVELOPMENT. TO SUPPORT DISSEMINATION OF RESEARCH FINDINGS. SMALL BUSINESS INNOVATION RESEARCH (SBIR) LEGISLATION IS INTENDED TO EXPAND AND IMPROVE THE SBIR PROGRAMS TO EMPHASIZE AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF TECHNOLOGY DEVELOPED THROUGH FEDERAL SBIR RESEARCH AND DEVELOPMENT, INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN THE SBIR PROGRAM. THE LEGISLATION INTENDS THAT THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders

National Institute on Drug Abuse (NIDA) [HHS - NIH]

National Institute of Neurological Disorders and Stroke (NNDS) [HHS - NIH]

Connecticut United States

State-Wide

BRAIN Initiative: Brain-Behavior Quantification and Synchronization Transformative and Integrative Models of Behavior at the Organismal Level (U01 Clinical Trials Not Allowed) (RFA-DA-24-041)

Amendment Since initial award the total obligations have increased 138% from $2,055,765 to $4,888,497.