U01CA265750

Population Modeling of Bladder Cancer Detection and Control - Abstract

Bladder cancer is the second most common genitourinary malignancy in the US, with approximately 80,000 new cases and 17,700 deaths each year. It is a heterogeneous set of diseases that range from locally treatable superficial tumors that are generally not life-threatening but require chronic management, to advanced disease that requires multimodal invasive treatments and has a higher risk of distal metastasis and death. It is also the ninth most expensive cancer overall in the US and, per diagnosed patient, the most expensive cancer to manage.

Risk factors for bladder cancer broadly include chemical and environmental exposures such as cigarette smoking and chemical carcinogens that are ingested or found in the workplace, as well as genetic abnormalities and chronic bladder irritation. Despite advancements in medical technology, outcomes for bladder cancer have remained relatively stable in the last two decades. However, there are opportunities to improve the prevention, detection, and management of bladder cancer. The advent of novel biomarkers and treatments, including immunotherapies (checkpoint inhibitors), gene therapies, and antibody-drug conjugates, may have a large impact in the coming years.

Bladder cancer is amenable to population modeling due to its high morbidity, mortality, and cost. It is likely preventable by minimizing smoking and toxin exposure, and the emergence of novel promising biomarkers and treatments further supports the need for population modeling. The long-term goal of our research program is to improve the effectiveness and efficiency of population- and person-level approaches to bladder cancer prevention, detection, and management given current knowledge and constraints.

The overall objective of the current proposal is to address major questions in the surveillance, treatment, prevention, and diagnosis of bladder cancer through comparative mathematical modeling. We will address six specific aims:

1. Complete the development, calibration, and validation of two independent population models of bladder cancer.
2. Explain secular trends in bladder cancer incidence in relation to trends in tobacco use in key population subgroups and estimate the impact of the 1964 Surgeon General's smoking recommendations.
3. Assess the effectiveness of smoking cessation, reduction, and prevention interventions for the prevention of bladder cancer incidence and mortality.
4. Assess the effectiveness and cost-effectiveness of generic and tailored/patient-centric surveillance policies for patients with non-muscle invasive bladder cancer.
5. Assess the comparative effectiveness of treatments for organ-confined bladder cancer.
6. Assess the effectiveness of screening for bladder cancer among high-risk subgroups.

Brown University

NOT APPLICABLE

93.393 - Cancer Cause and Prevention Research

National Cancer Institute (NCI) [HHS - NIH]

Providence, Rhode Island 029034202 United States

Single Zip Code

Cancer Intervention and Surveillance Modeling Network (CISNET) Incubator Program for New Cancer Sites (U01 Clinical Trial Not Allowed) (RFA-CA-20-043)

Amendment Since initial award the total obligations have increased 274% from $707,395 to $2,648,898.