U01CA258400

Development of Small Area Interactive Risk Maps for Cancer Control Efforts - Project Summary

This study will use a Bayesian hierarchical modeling statistical framework to obtain rates of new cancer cases and cancer deaths at the zip-code level, which will allow cancer control researchers and practitioners to focus their efforts on populations at greatest risk. The Bayesian hierarchical model will produce small area estimates by borrowing strength from neighboring zip-codes as well as over time.

Typically, the zip-code levels would need to be combined to much larger regions to obtain sample sizes big enough to either de-identify individuals or stabilize the variance, or both. We employ a zero-inflated model since many zip-codes will have small and especially zero counts in a given year and age group.

Given that the challenges of, and needs for, calculating small area cancer estimates is greatest in rural areas, we will focus on the largely rural states of Iowa, Kentucky, and New Mexico. We will then construct user-friendly maps and other interactive graphics that can be tailored and included on cancer control/public health websites and develop communication and educational materials to promote the use of these maps for cancer control purposes.

The result is an interactive visualization approach that displays age-adjusted cancer rates, risk of cancer relative to the state average, and levels of confidence, all at the small area zip-code level even for rural areas with small and zero counts. The probabilities and cancer risk estimates will be disseminated through a widely available platform that is easy to use and understand.

The University Of Iowa

TO IDENTIFY CANCER RISKS AND RISK REDUCTION STRATEGIES, TO IDENTIFY FACTORS THAT CAUSE CANCER IN HUMANS, AND TO DISCOVER AND DEVELOP MECHANISMS FOR CANCER PREVENTION AND PREVENTIVE INTERVENTIONS IN HUMANS. RESEARCH PROGRAMS INCLUDE: (1) CHEMICAL, PHYSICAL AND MOLECULAR CARCINOGENESIS, (2) SCREENING, EARLY DETECTION AND RISK ASSESSMENT, INCLUDING BIOMARKER DISCOVERY, DEVELOPMENT AND VALIDATION, (3) EPIDEMIOLOGY, (4) NUTRITION AND BIOACTIVE FOOD COMPONENTS, (5) IMMUNOLOGY AND VACCINES, (6) FIELD STUDIES AND STATISTICS, (7) CANCER CHEMOPREVENTION AND INTERCEPTION, (8) PRE-CLINICAL AND CLINICAL AGENT DEVELOPMENT, (9) ORGAN SITE STUDIES AND CLINICAL TRIALS, (10) HEALTH-RELATED QUALITY OF LIFE AND PATIENT-CENTERED OUTCOMES, AND (11) SUPPORTIVE CARE AND MANAGEMENT OF SYMPTOMS AND TOXICITIES. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO STIMULATE TECHNICAL INNOVATION, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY WOMEN AND SOCIALLY/ECONOMICALLY DISADVANTAGED PERSONS. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT FUNDING, AND FOSTER PARTICIPATION IN INNOVATION AND ENTREPRENEURSHIP BY WOMEN AND SOCIALLY/ECONOMICALLY DISADVANTAGED PERSONS.

93.393 - Cancer Cause and Prevention Research

National Cancer Institute (NCI) [HHS - NIH]

Iowa City, Iowa 52242 United States

Single Zip Code

Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional) (RFA-CA-21-014)

Amendment Since initial award the total obligations have increased 172% from $349,606 to $950,181.