U01AI183951

Biomedical science and public health research to address national and global health challenges through a collaboration between US NIH and WHO - the World Health Organization (WHO), as specified in its Constitution, is the “directing and coordinating authority on international health work”.

The organization develops global norms and standards and provides scientific and technical assistance to member states.

Especially since the creation of the Science Division in 2019, WHO has increasingly focused on, and will in the future be a science-based organization, ensuring that the very best available science informs its work and advice.

WHO maintains deep collaboration with governments and research organizations throughout the world, including through its unique network of country and regional offices and the network of WHO collaborating centres.

WHO’s research portfolio is complementary to the goals of NIH’s specialized institutes, covering communicable and noncommunicable diseases, and endemic, epidemic, and emerging health threats.

As a global leader in biomedical research, NIH is a critical partner for WHO in advancing the scientific knowledge base and in the development of effective interventions.

This proposal aims to enhance collaboration between NIH and WHO to strengthen research in support of the most pressing public health needs.

Enhanced collaboration will be achieved by combining the strengths of both organizations, building on NIH’s excellence in medical and biomedical research and its access to a vast research infrastructure, and on WHO’s global reach, expertise in setting norms and standards, and in implementation science.

Five major activities are proposed in these areas: infectious disease global health research; immunization agenda 2030; genomics for global health, including the WHO Science Council; collaboration for cancer control; global mental health agenda; and a global health activity fund.

The collaboration will make use of WHO’s broad scientific experience, its capacity to convene independent global experts and set agendas, and to develop consensus through transparent and inclusive consultative processes, taking into consideration all geographic regions and communities, exploiting WHO’s decentralized structure.

This application proposes collaborative action in emerging issues in public health that require investments in basic, translational, and implementation research.

There is significant room for expansion of collaborative activities that support the shared goals and objectives of the institutions of NIH and WHO.

World Health Organization

TO ASSIST PUBLIC AND PRIVATE NONPROFIT INSTITUTIONS AND INDIVIDUALS TO ESTABLISH, EXPAND AND IMPROVE BIOMEDICAL RESEARCH AND RESEARCH TRAINING IN INFECTIOUS DISEASES AND RELATED AREAS, TO CONDUCT DEVELOPMENTAL RESEARCH, TO PRODUCE AND TEST RESEARCH MATERIALS. TO ASSIST PUBLIC, PRIVATE AND COMMERCIAL INSTITUTIONS TO CONDUCT DEVELOPMENTAL RESEARCH, TO PRODUCE AND TEST RESEARCH MATERIALS, TO PROVIDE RESEARCH SERVICES AS REQUIRED BY THE AGENCY FOR PROGRAMS IN INFECTIOUS DISEASES, AND CONTROLLING DISEASE CAUSED BY INFECTIOUS OR PARASITIC AGENTS, ALLERGIC AND IMMUNOLOGIC DISEASES AND RELATED AREAS. PROJECTS RANGE FROM STUDIES OF MICROBIAL PHYSIOLOGY AND ANTIGENIC STRUCTURE TO COLLABORATIVE TRIALS OF EXPERIMENTAL DRUGS AND VACCINES, MECHANISMS OF RESISTANCE TO ANTIBIOTICS AS WELL AS RESEARCH DEALING WITH EPIDEMIOLOGICAL OBSERVATIONS IN HOSPITALIZED PATIENTS OR COMMUNITY POPULATIONS AND PROGRESS IN ALLERGIC AND IMMUNOLOGIC DISEASES. BECAUSE OF THIS DUAL FOCUS, THE PROGRAM ENCOMPASSES BOTH BASIC RESEARCH AND CLINICAL RESEARCH. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM EXPANDS AND IMPROVES PRIVATE SECTOR PARTICIPATION IN BIOMEDICAL RESEARCH. THE SBIR PROGRAM INTENDS TO INCREASE AND FACILITATE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM STIMULATES AND FOSTERS SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. RESEARCH CAREER DEVELOPMENT AWARDS SUPPORT THE DEVELOPMENT OF SCIENTISTS DURING THE FORMATIVE STAGES OF THEIR CAREERS. INDIVIDUAL NATIONAL RESEARCH SERVICE AWARDS (NRSAS) ARE MADE DIRECTLY TO APPROVE APPLICANTS FOR RESEARCH TRAINING IN SPECIFIED BIOMEDICAL SHORTAGE AREAS. IN ADDITION, INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDS ARE MADE TO ENABLE INSTITUTIONS TO SELECT AND MAKE AWARDS TO INDIVIDUALS TO RECEIVE TRAINING UNDER THE AEGIS OF THEIR INSTITUTIONAL PROGRAM.

93.865 - Child Health and Human Development Extramural Research

National Institute of Allergy and Infectious Diseases (NIAID) [HHS - NIH]

National Institute of Child Health and Human Development (NICHD) [HHS - NIH]

Switzerland

Foreign

Limited Competition: Collaborative Partnership to Advance Global Health Research (U01 Clinical Trial Not Allowed) (PAR-23-203)

Amendment Since initial award the total obligations have increased 2930% from $100,000 to $3,030,003.