U01AI160082

Childhood Asthma in Urban Settings - The overall objective of this study is to provide the NIAID Childhood Asthma in Urban Settings Clinical Research Network Center (CAUSE) with a highly developed and experienced Clinical Research Center (CRC) at the Mount Sinai Health Care System. We propose that the Mount Sinai Health Care System is well-positioned and prepared to create a NIAID CAUSE-CRC to conduct network and center-specific studies based upon:

1) Our success recruiting and retaining subjects in asthma studies from urban populations;
2) Investigators actively conducting innovative research to understand mechanisms of atopic diseases;
3) Established and well-organized clinical research programs with committed staff to conduct research studies;
4) Facilities and institutional support to ensure the success of this proposal; and
5) A large population of high-risk urban children/adolescents with asthma who receive care and participate in research at the Mount Sinai Health System.

The proposed Mount Sinai CAUSE-CRC includes a team of investigators with strong backgrounds relevant to asthma, allergy, immunology, epidemiology, transcriptomics, microbiome, and systems biology who have previously collaborated. MPIs Drs. Busse, Bunyavanich, and Wisnivesky have served as PIs on several NIH and PCORI-sponsored asthma and allergic diseases networks (including ICAC-II, III sub-studies) and individually funded studies investigating determinants of asthma self-management, disparities in care, mechanisms of airway inflammation, -omics, and systems biology. The Mount Sinai CRC is supported by co-investigators Drs. Wright and Miller who have extensive experience in pediatric asthma network studies. Our team includes research coordinators, nurses, laboratory technicians, statisticians, bioinformaticians, pharmacists, and regulatory members who have worked with the investigators, which will allow us to successfully recruit, conduct protocols, maintain the integrity of study data, and coordinate with the LC and contract research organizations.

Our center-specific Project 1 will investigate the influence of concurrent AD on asthma control in urban children and will be conducted with Dr. Guttman-Yassky, an expert in atopic dermatitis at Mount Sinai. Project 2 will investigate the association between L-arginine/asymmetric dimethyl arginine and asthma morbidity in obese urban adolescents with asthma. Our individual research projects provide novel information on the mechanisms and a future treatment approach with a more precise benefit in children with asthma and AD in an urban setting.

Icahn School Of Medicine At Mount Sinai

TO ASSIST PUBLIC AND PRIVATE NONPROFIT INSTITUTIONS AND INDIVIDUALS TO ESTABLISH, EXPAND AND IMPROVE BIOMEDICAL RESEARCH AND RESEARCH TRAINING IN INFECTIOUS DISEASES AND RELATED AREAS, TO CONDUCT DEVELOPMENTAL RESEARCH, TO PRODUCE AND TEST RESEARCH MATERIALS. TO ASSIST PUBLIC, PRIVATE AND COMMERCIAL INSTITUTIONS TO CONDUCT DEVELOPMENTAL RESEARCH, TO PRODUCE AND TEST RESEARCH MATERIALS, TO PROVIDE RESEARCH SERVICES AS REQUIRED BY THE AGENCY FOR PROGRAMS IN INFECTIOUS DISEASES, AND CONTROLLING DISEASE CAUSED BY INFECTIOUS OR PARASITIC AGENTS, ALLERGIC AND IMMUNOLOGIC DISEASES AND RELATED AREAS. PROJECTS RANGE FROM STUDIES OF MICROBIAL PHYSIOLOGY AND ANTIGENIC STRUCTURE TO COLLABORATIVE TRIALS OF EXPERIMENTAL DRUGS AND VACCINES, MECHANISMS OF RESISTANCE TO ANTIBIOTICS AS WELL AS RESEARCH DEALING WITH EPIDEMIOLOGICAL OBSERVATIONS IN HOSPITALIZED PATIENTS OR COMMUNITY POPULATIONS AND PROGRESS IN ALLERGIC AND IMMUNOLOGIC DISEASES. BECAUSE OF THIS DUAL FOCUS, THE PROGRAM ENCOMPASSES BOTH BASIC RESEARCH AND CLINICAL RESEARCH. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM EXPANDS AND IMPROVES PRIVATE SECTOR PARTICIPATION IN BIOMEDICAL RESEARCH. THE SBIR PROGRAM INTENDS TO INCREASE AND FACILITATE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM STIMULATES AND FOSTERS SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. RESEARCH CAREER DEVELOPMENT AWARDS SUPPORT THE DEVELOPMENT OF SCIENTISTS DURING THE FORMATIVE STAGES OF THEIR CAREERS. INDIVIDUAL NATIONAL RESEARCH SERVICE AWARDS (NRSAS) ARE MADE DIRECTLY TO APPROVE APPLICANTS FOR RESEARCH TRAINING IN SPECIFIED BIOMEDICAL SHORTAGE AREAS. IN ADDITION, INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDS ARE MADE TO ENABLE INSTITUTIONS TO SELECT AND MAKE AWARDS TO INDIVIDUALS TO RECEIVE TRAINING UNDER THE AEGIS OF THEIR INSTITUTIONAL PROGRAM.

93.855 - Allergy and Infectious Diseases Research

National Institute of Allergy and Infectious Diseases (NIAID) [HHS - NIH]

New York, New York 100296504 United States

Single Zip Code

Childhood Asthma in Urban Settings -Clinical Research Centers (U01 Clinical Trial Optional) (RFA-AI-19-073)

Amendment Since initial award the total obligations have increased 402% from $431,343 to $2,163,187.