U01AG076482

Additional Sequencing for the Alzheimer Disease Sequencing Project (ADSP), the Follow-Up Study (FUS), the Diverse Population Initiative - Abstract

The Alzheimer's Disease Sequencing Project (ADSP) is a national sequencing initiative focused on identifying genetic risk factors for AD. The project's discovery phase includes whole exome sequencing (WES) of 10,061 unrelated non-white Hispanic individuals of European ancestry (NHW-EA) cases (N=5,096) and controls (N=4,965), and whole genome sequencing (WGS) of 584 NHW and Hispanic/Latino (HL) familial samples. The 'discovery extension phase' of the project added WGS on approximately 430 additional familial samples.

The ADSP Follow-Up Study 1.0 (ADSP-FUS 1.0) phase focused on examining candidate variants from the discovery phase, and identification of novel variants through combined analysis of diverse datasets, is ongoing. Its aim is to sequence existing cohorts with unrelated AD cases that 'encompass the richest possible ethnic diversity', as well as a highly valuable set of autopsy confirmed cases and controls. In total, we have already included in FUS over 50,000 samples for sequencing, including more than 4,700 autopsy confirmed cases and controls, over 9,400 HL ancestry cases and controls, and over 8,300 African ancestry (AA) cases and controls.

In this ADSP-FUS 2.0 application, which focuses on the PAR-21-212 goal to increase diversity cohorts in the ADSP with WGS, we are proposing sequencing, quality control, and phenotype harmonization of an additional approximately 16,000 individuals. These individuals include approximately 12,000 HL ancestry, 500 autopsied NHW-EA, approximately 3,400 AA, and approximately 170 Asian ancestry individuals. This expansion will both increase our power to find effects and enhance our ability to find genetic effects in underserved groups. Additionally, these datasets will become an invaluable resource for the AD research community at large.

University Of Miami

TO ENCOURAGE BIOMEDICAL, SOCIAL, AND BEHAVIORAL RESEARCH AND RESEARCH TRAINING DIRECTED TOWARD GREATER UNDERSTANDING OF THE AGING PROCESS AND THE DISEASES, SPECIAL PROBLEMS, AND NEEDS OF PEOPLE AS THEY AGE. THE NATIONAL INSTITUTE ON AGING HAS ESTABLISHED PROGRAMS TO PURSUE THESE GOALS. THE DIVISION OF AGING BIOLOGY EMPHASIZES UNDERSTANDING THE BASIC BIOLOGICAL PROCESSES OF AGING. THE DIVISION OF GERIATRICS AND CLINICAL GERONTOLOGY SUPPORTS RESEARCH TO IMPROVE THE ABILITIES OF HEALTH CARE PRACTITIONERS TO RESPOND TO THE DISEASES AND OTHER CLINICAL PROBLEMS OF OLDER PEOPLE. THE DIVISION OF BEHAVIORAL AND SOCIAL RESEARCH SUPPORTS RESEARCH THAT WILL LEAD TO GREATER UNDERSTANDING OF THE SOCIAL, CULTURAL, ECONOMIC AND PSYCHOLOGICAL FACTORS THAT AFFECT BOTH THE PROCESS OF GROWING OLD AND THE PLACE OF OLDER PEOPLE IN SOCIETY. THE DIVISION OF NEUROSCIENCE FOSTERS RESEARCH CONCERNED WITH THE AGE-RELATED CHANGES IN THE NERVOUS SYSTEM AS WELL AS THE RELATED SENSORY, PERCEPTUAL, AND COGNITIVE PROCESSES ASSOCIATED WITH AGING AND HAS A SPECIAL EMPHASIS ON ALZHEIMER'S DISEASE. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

Florida United States

State-Wide

Limited Competition: Alzheimers Disease Sequencing Project Follow-Up Study 2.0 (ADSP FUS 2.0): The Diverse Population Initiative (U01 Clinical Trial Not Allowed) (PAR-21-212)

Amendment Since initial award the End Date has been extended from 08/31/27 to 08/31/28 and the total obligations have increased 196% from $6,962,692 to $20,575,729.