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T32GM152319

Project Grant

Overview

Grant Description
Medical Scientist Training Program at Case Western Reserve University - our School of Medicine launched the first MD-PhD training program in 1956, and the program has a long history of innovation and success with many prominent alumni, including two Nobel Laureates.

Our mission is to develop MD-PhD training to train a diverse pool of physician-scientist leaders to meet future biomedical research workforce needs for research leaders to accelerate research to advance the understanding, detection, treatment and prevention of human disease.

Objectives include development of physician-scientists with deep expertise in one or more biomedical scientific disciplines coupled with a broad understanding across biomedical disciplines; skills to independently design and develop research programs; ability to use clinical insights to inform research; and commitment to scientific integrity and DEI goals.

Program goals include MD-PhD completion with an efficient time to degree (TTD), publication and grants attainment productivity, post-graduation placement in training programs related to physician-scientist career development, and long-term attainment of productive research careers.

Our aims include development of an MD-PhD curriculum that integrates research and clinical training with deep research experiences from the beginning of the program to promote retention of trainees in the research mission and foster curricular efficiency.

We will develop required and elective MSTP activities that promote the program objectives, including didactic, research, mentoring and career development elements (RCR, RRR, grantsmanship, research communication and others) and program activities (MSTP retreat, MSTP dinner seminars, MSTP visiting physician-scientist career sessions).

We will work with our research training community to improve PhD programs and training of research mentors in best practices.

Our approach includes integration of research and clinical training within each of the three basic phases: first two years (M1-M2), PhD phase (e.g. G1-4), and last two years (M3-M4). The curriculum has flexibility to meet the differing interests and needs of individual students.

A key strategy is early and deep engagement with research to promote research career development and retention - in M1-M2, students complete a research rotation or graduate course in every semester in combination with the MD curriculum.

Almost all students match into their PhD lab by fall of M2, allowing early launch of PhD research in M2. This is a key distinction for the CWRU MSTP and provides unique curricular opportunities.

We will establish a culture of support for students and engagement of student leadership in MSTP council to shape the program to support student professional development and wellness.

We will continue to admit 14-15 students per year. The integrated research and clinical curriculum, program activities, DEI focus and activities, and support for students will produce a highly skilled and diverse physician-scientist workforce, which will contribute to national goals for basic, translational and clinical research in academia, government and industry.
Funding Goals
THE NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES (NIGMS) SUPPORTS BASIC RESEARCH THAT INCREASES OUR UNDERSTANDING OF BIOLOGICAL PROCESSES AND LAYS THE FOUNDATION FOR ADVANCES IN DISEASE DIAGNOSIS, TREATMENT, AND PREVENTION. NIGMS ALSO SUPPORTS RESEARCH IN SPECIFIC CLINICAL AREAS THAT AFFECT MULTIPLE ORGAN SYSTEMS: ANESTHESIOLOGY AND PERI-OPERATIVE PAIN, CLINICAL PHARMACOLOGY ?COMMON TO MULTIPLE DRUGS AND TREATMENTS, AND INJURY, CRITICAL ILLNESS, SEPSIS, AND WOUND HEALING.? NIGMS-FUNDED SCIENTISTS INVESTIGATE HOW LIVING SYSTEMS WORK AT A RANGE OF LEVELSFROM MOLECULES AND CELLS TO TISSUES AND ORGANSIN RESEARCH ORGANISMS, HUMANS, AND POPULATIONS. ADDITIONALLY, TO ENSURE THE VITALITY AND CONTINUED PRODUCTIVITY OF THE RESEARCH ENTERPRISE, NIGMS PROVIDES LEADERSHIP IN SUPPORTING THE TRAINING OF THE NEXT GENERATION OF SCIENTISTS, ENHANCING THE DIVERSITY OF THE SCIENTIFIC WORKFORCE, AND DEVELOPING RESEARCH CAPACITY THROUGHOUT THE COUNTRY.
Place of Performance
Cleveland, Ohio 44106 United States
Geographic Scope
Single Zip Code
Analysis Notes
Amendment Since initial award the total obligations have increased 104% from $1,678,206 to $3,430,948.
Case Western Reserve University was awarded CWRU MSTP: Developing Physician-Scientist Leaders Project Grant T32GM152319 worth $3,430,948 from National Center for Advancing Translational Sciences in July 2024 with work to be completed primarily in Cleveland Ohio United States. The grant has a duration of 5 years and was awarded through assistance program 93.350 National Center for Advancing Translational Sciences. The Project Grant was awarded through grant opportunity Medical Scientist Training Program (T32).

Status
(Ongoing)

Last Modified 8/20/25

Period of Performance
7/1/24
Start Date
6/30/29
End Date
23.0% Complete

Funding Split
$3.4M
Federal Obligation
$0.0
Non-Federal Obligation
$3.4M
Total Obligated
100.0% Federal Funding
0.0% Non-Federal Funding

Activity Timeline

Interactive chart of timeline of amendments to T32GM152319

Transaction History

Modifications to T32GM152319

Additional Detail

Award ID FAIN
T32GM152319
SAI Number
T32GM152319-2629110754
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Private Institution Of Higher Education
Awarding Office
75NS00 NIH National Institute of General Medical Sciences
Funding Office
75NR00 NIH National Center for Advancing Translational Sciences
Awardee UEI
HJMKEF7EJW69
Awardee CAGE
4B566
Performance District
OH-11
Senators
Sherrod Brown
J.D. (James) Vance
Modified: 8/20/25