SB1ES029401
Project Grant
Overview
Grant Description
Remediation of perfluorinated chemicals in water using novel high-affinity polymer adsorbents - Abstract
Contamination of water supplies by toxic per- and polyfluoroalkyl substances is a major health and environmental issue impacting society today. Given the environmental persistence of these contaminants and their established linkage to serious health risks, it is imperative that safe, efficient, and cost-effective PFAS remediation technologies be developed that can eliminate these contaminants from the U.S. water supplies.
With the tightening of health-based contamination limits and the expansion of regulated PFAS structures, the impacts of PFAS contamination are now estimated to affect over 200 million Americans. NIEHS sponsored DEXSORB adsorbent represents a breakthrough solution for the safe, rapid, and cost-effective removal of short- and long-chain PFAS compounds, including PFOA and PFOS from water. It takes exacting technology to remove PFAS compounds at the trace levels being mandated by states and the EPA.
Made from renewable cyclodextrins, DEXSORB’s ability to selectively target PFAS compounds at trace concentrations with rapid uptake, high capacity, and resistance to fouling make it ideally suited for use in private and municipal water treatment systems. Working with environmental partners, Cyclopure has demonstrated the superior performance and favorable life cycle economies of DEXSORB in pilot water treatment activities.
To advance further, specific milestones that upon completion will help Cyclopure transition to full commercialization stage have been identified in this CRP proposal. Cyclopure’s main objective in this program will be to seek support for regulatory and manufacturing assistance. Both areas are critical prior to the commencement of full-scale manufacturing and commercialization activities.
Safety and health related information and associated experimental data will be collected and organized for material registrations and certifications as required by regulatory agencies including EPA and NSF International. Activities under manufacturing assistance will support developing an optimal purification method that is expected to provide significant cost and process improvements in a full-scale manufacturing environment.
Successful completion of this proposed work will enable Cyclopure to transition to large-scale production and work with industry partners to make DEXSORB available to provide PFAS removal for consumer and municipal applications.
Contamination of water supplies by toxic per- and polyfluoroalkyl substances is a major health and environmental issue impacting society today. Given the environmental persistence of these contaminants and their established linkage to serious health risks, it is imperative that safe, efficient, and cost-effective PFAS remediation technologies be developed that can eliminate these contaminants from the U.S. water supplies.
With the tightening of health-based contamination limits and the expansion of regulated PFAS structures, the impacts of PFAS contamination are now estimated to affect over 200 million Americans. NIEHS sponsored DEXSORB adsorbent represents a breakthrough solution for the safe, rapid, and cost-effective removal of short- and long-chain PFAS compounds, including PFOA and PFOS from water. It takes exacting technology to remove PFAS compounds at the trace levels being mandated by states and the EPA.
Made from renewable cyclodextrins, DEXSORB’s ability to selectively target PFAS compounds at trace concentrations with rapid uptake, high capacity, and resistance to fouling make it ideally suited for use in private and municipal water treatment systems. Working with environmental partners, Cyclopure has demonstrated the superior performance and favorable life cycle economies of DEXSORB in pilot water treatment activities.
To advance further, specific milestones that upon completion will help Cyclopure transition to full commercialization stage have been identified in this CRP proposal. Cyclopure’s main objective in this program will be to seek support for regulatory and manufacturing assistance. Both areas are critical prior to the commencement of full-scale manufacturing and commercialization activities.
Safety and health related information and associated experimental data will be collected and organized for material registrations and certifications as required by regulatory agencies including EPA and NSF International. Activities under manufacturing assistance will support developing an optimal purification method that is expected to provide significant cost and process improvements in a full-scale manufacturing environment.
Successful completion of this proposed work will enable Cyclopure to transition to large-scale production and work with industry partners to make DEXSORB available to provide PFAS removal for consumer and municipal applications.
Awardee
Funding Goals
TO SUPPORT INNOVATE RESEARCH AND TRAINING THROUGH MULTI-PROJECT, INTERDISCIPLINARY GRANTS, INDIVIDUAL INVESTIGATOR RESEARCH GRANTS, RESEARCH EDUCATION PROGRAM GRANTS, SMALL BUSINESS INNOVATIVE RESEARCH (SBIR) GRANTS, TIME-SENSITIVE GRANTS, AND CONFERENCE GRANTS. AREAS OF RESEARCH MAY INCLUDE: (1) ADVANCED TECHNIQUES FOR THE DETECTION, ASSESSMENT, AND EVALUATION OF THE EFFECT ON HUMAN HEALTH OF HAZARDOUS SUBSTANCES, (2) METHODS TO ASSESS THE RISKS TO HUMAN HEALTH PRESENTED BY HAZARDOUS SUBSTANCES, (3) METHODS AND TECHNOLOGIES TO DETECT HAZARDOUS SUBSTANCES IN THE ENVIRONMENT, AND (4) BASIC BIOLOGICAL, CHEMICAL, AND PHYSICAL METHODS TO REDUCE THE AMOUNT AND TOXICITY OF HAZARDOUS SUBSTANCES.
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Illinois
United States
Geographic Scope
State-Wide
Related Opportunity
Analysis Notes
Amendment Since initial award the total obligations have increased 36% from $203,864 to $276,239.
Cyclopure was awarded
Project Grant SB1ES029401
worth $276,239
from the National Institute of Environmental Health Sciences in April 2018 with work to be completed primarily in Illinois United States.
The grant
has a duration of 6 years 4 months and
was awarded through assistance program 93.143 NIEHS Superfund Hazardous Substances Basic Research and Education.
The Project Grant was awarded through grant opportunity SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance (SB1, Clinical Trial Not Allowed).
SBIR Details
Research Type
SBIR Phase II
Title
Remediation of Perfluorinated Chemicals in Water Using Novel High-Affinity Polymer Adsorbents
Abstract
Abstract Contamination of water supplies by toxic per- and polyfluoroalkyl substances is a major health and environmental issue impacting society today. Given the environmental persistence of these contaminants and their established linkage to serious health risks, it is imperative that safe, efficient, and cost-effective PFAS remediation technologies be developed that can eliminate these contaminants from the U.S. water supplies. With the tightening of health-based contamination limits and the expansion of regulated PFAS structures, the impacts of PFAS contamination are now estimated to affect over 200 million Americans. NIEHS sponsored DEXSORB adsorbent represents a breakthrough solution for the safe, rapid, and cost-effective removal of short- and long- chain PFAS compounds, including PFOA and PFOS from water. It takes exacting technology to remove PFAS compounds at the trace levels being mandated by States and the EPA. Made from renewable cyclodextrins, DEXSORB’s ability to selectively target PFAS compounds at trace concentrations with rapid uptake, high capacity, and resistance to fouling make it ideally suited for use in private and municipal water treatment systems. Working with environmental partners, Cyclopure has demonstrated the superior performance and favorable life cycle economies of DEXSORB in pilot water treatment activities. To advance further, specific milestones that upon completion will help Cyclopure transition to full commercialization stage have been identified in this CRP proposal. Cyclopure’s main objective in this program will be to seek support for regulatory and manufacturing assistance. Both areas are critical prior to the commencement of full-scale manufacturing and commercialization activities. Safety and health related information and associated experimental data will be collected and organized for material registrations and certifications as required by regulatory agencies including EPA and NSF International. Activities under manufacturing assistance will support developing an optimal purification method that is expected to provide significant cost and process improvements in a full-scale manufacturing environment. Successful completion of this proposed work will enable Cyclopure to transition to large-scale production and work with industry partners to make DEXSORB available to provide PFAS removal for consumer and municipal applications.
Topic Code
R
Solicitation Number
PAR20-128
Status
(Complete)
Last Modified 3/5/25
Period of Performance
4/1/18
Start Date
8/31/24
End Date
Funding Split
$276.2K
Federal Obligation
$0.0
Non-Federal Obligation
$276.2K
Total Obligated
Activity Timeline
Transaction History
Modifications to SB1ES029401
Additional Detail
Award ID FAIN
SB1ES029401
SAI Number
SB1ES029401-3413709056
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Small Business
Awarding Office
75NV00 NIH National Institute of Enviromental Health Sciences
Funding Office
75NV00 NIH National Institute of Enviromental Health Sciences
Awardee UEI
LBJ7HD24LWG1
Awardee CAGE
7QW88
Performance District
IL-90
Senators
Richard Durbin
Tammy Duckworth
Tammy Duckworth
Budget Funding
| Federal Account | Budget Subfunction | Object Class | Total | Percentage |
|---|---|---|---|---|
| National Institute of Environmental Health Sciences, National Institutes of Health, Health and Human Services (075-0862) | Health research and training | Grants, subsidies, and contributions (41.0) | $276,239 | 100% |
Modified: 3/5/25