RM1HG011543

Center for Live Cell Genomics - Abstract

The Center for Live Cell Genomics aims to develop new methodology and capacity for large-scale, long-term, inexpensive, modular, customizable, shared, Internet-of-Things-controlled, reproducible live cell culture and tissue-based experimental genomics disease models. These tissue models include traditional cell culture, as well as organoid and primary tissue explants obtained from surgery or biopsy.

Organoid factories that support tissue growth and maintenance will be integrated with external and on-chip electro-optofluidic analytical modules. This integration will create an ecosystem modeled after open-source software. The center will utilize commodity sensors, cameras, and computers linked in platforms that are flexibly designed using simple 3D printing, molding, etching, and milling techniques. These techniques will potentially be available at any institution, stimulating rapid innovation in experimental platforms for tissue culture.

The technology developed by the center will be used to make progress in neurodevelopment and pediatric cancer research. Specifically, the center aims to answer important questions such as: What genes contribute most importantly and specifically to human brain development? How do these genes go wrong in neurodevelopmental disease or brain injury? What specific molecular pathways are disrupted in individual pediatric cancer cases? How can pathway-specific treatments be tested in a tissue model specific to each patient?

In addition to research, the center has plans for education and outreach. This includes a training program to develop a diverse and inclusive cohort of undergraduate students trained in genomic science through secondary school and community college outreach. Coding workshops and research-based laboratory classes will also be provided for UCSC undergraduates to develop core competencies. Participation in these activities will serve as a basis for training graduate students and postdocs in inclusive pedagogy and mentorship.

Furthermore, the center is developing a one-stop information hub to form an online community and share their technology through immersive webinars and tutorials. These resources are aimed at a broader audience with a range of expertise, from the general public to scientists and clinicians at research institutions.

The work of the center will enable significant advances in neuroscience and cancer research and education. It will also stimulate a new open-source culture in cell biology and genomics, and democratize scientific and educational access beyond elite institutions. The center aims to extend sharing projects like NHGRI AnVIL beyond data and code to include experiments and Internet-connected experimental platforms.

Santa Cruz University Of California

NHGRI SUPPORTS THE DEVELOPMENT OF RESOURCES AND TECHNOLOGIES THAT WILL ACCELERATE GENOME RESEARCH AND ITS APPLICATION TO HUMAN HEALTH AND GENOMIC MEDICINE. A CRITICAL PART OF THE NHGRI MISSION CONTINUES TO BE THE STUDY OF THE ETHICAL, LEGAL AND SOCIAL IMPLICATIONS (ELSI) OF GENOME RESEARCH. NHGRI ALSO SUPPORTS THE TRAINING AND CAREER DEVELOPMENT OF INVESTIGATORS AND THE DISSEMINATION OF GENOME INFORMATION TO THE PUBLIC AND TO HEALTH PROFESSIONALS. THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM IS USED TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM IS USED TO FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.172 - Human Genome Research

National Human Genome Research Institute (NHGRI) [HHS - NIH]

Santa Cruz, California 950641077 United States

Single Zip Code

Centers of Excellence in Genomic Science (RM1 Clinical Trials Optional) (PAR-19-204)

Amendment Since initial award the total obligations have increased 378% from $2,506,350 to $11,992,289.