RM1DA055310

Heal Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers

There is an urgent need to conduct high impact multidisciplinary research for patients with chronic pain (CP) and opioid use disorder (OUD) in the settings where they receive care and in collaboration with stakeholders and persons with lived experience (PWLE).

We propose to create the Integrative Management of Chronic Pain and OUD for Whole Recovery – Yale and Organizations United (IMPOWR-YOU). IMPOWR-YOU is a multidisciplinary center led by established investigators with expertise studying CP and opioid use disorder/misuse (OUD/misuse) and working in partnership with stakeholders and PWLE. We conduct research in general medical settings (primary care, hospital) and specialty (opioid treatment programs (OTPs)) with a focus on supporting the career development of early stage investigators and those from groups traditionally underrepresented in research (URG).

IMPOWR-YOU is comprised of 5 cores (Operations, Stakeholder/PWLE, Career Development and Diversity, Pilot Projects, Data and Measurement), 2 research projects, and annual pilot projects. Our research, built on previous work of our investigators and stakeholders, addresses critical issues that face practitioners across the healthcare system. Proposed studies include:

1) In primary care, compare the effectiveness of a pharmacist-led collaborative care approach for patients prescribed long-term opioids who have CP and OUD/misuse vs. the pharmacist program plus patient referral to a phone-delivered, cognitive behavior therapy (CBT)-based pain self-management program.

2) In an OTP, compare the effectiveness of a stepped care multimodal interdisciplinary CP management that includes CBT, exercise, and stress management to treatment as usual in patients receiving methadone or buprenorphine.

3) In year 1, conduct a pilot to modify an opioid stewardship program to address the needs of hospitalized patients with CP and OUD and evaluate its preliminary efficacy.

All studies include outcomes related to pain, OUD, alcohol use, anxiety, depressive symptoms, sleep problems, and some assess stress, stigma, and recovery capital. Our pilot project core will oversee the selection of pilots in years 2-5 to support early stage investigators and collaborations with stakeholders/PWLE.

IMPOWR-YOU is built on long-standing multidisciplinary research collaborations among diverse stakeholders, including PWLE, early stage investigators, URG, health systems, and organizations that produce guidelines for CP and OUD/misuse. IMPOWR-YOU has the ideal mixture of investigators, including leaders in primary care, addiction medicine/psychiatry, psychology specialty care, clinical trials, qualitative research, and implementation science. We have established relationships with stakeholders and PWLE, a track record of innovation, leadership, collaboration, and outstanding productivity to create a leading center that will contribute to addressing the unique needs of patients with CP and OUD/misuse.

Yale Univ

TO SUPPORT BASIC AND CLINICAL NEUROSCIENCE, BIOMEDICAL, BEHAVIORAL AND SOCIAL SCIENCE, EPIDEMIOLOGIC, HEALTH SERVICES AND HEALTH DISPARITY RESEARCH. TO DEVELOP NEW KNOWLEDGE AND APPROACHES RELATED TO THE PREVENTION, DIAGNOSIS, TREATMENT, ETIOLOGY, AND CONSEQUENCES OF DRUG ABUSE AND ADDICTION, INCLUDING HIV/AIDS. TO SUPPORT RESEARCH TRAINING AND RESEARCH SCIENTIST DEVELOPMENT. TO SUPPORT DISSEMINATION OF RESEARCH FINDINGS. SMALL BUSINESS INNOVATION RESEARCH (SBIR) LEGISLATION IS INTENDED TO EXPAND AND IMPROVE THE SBIR PROGRAMS TO EMPHASIZE AND INCREASE PRIVATE SECTOR COMMERCIALIZATION OF TECHNOLOGY DEVELOPED THROUGH FEDERAL SBIR RESEARCH AND DEVELOPMENT, INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN THE SBIR PROGRAM. THE LEGISLATION INTENDS THAT THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.279 - Drug Abuse and Addiction Research Programs

National Institute on Drug Abuse (NIDA) [HHS - NIH]

National Institute of Neurological Disorders and Stroke (NNDS) [HHS - NIH]

Connecticut United States

State-Wide

HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required) (RFA-DA-21-030)

Amendment Since initial award the End Date has been extended from 07/31/23 to 07/31/26 and the total obligations have increased 148% from $4,761,350 to $11,818,051.