RF1NS041588

UNDERSTANDING COHORT EFFECTS ON STROKE, VCID, AND COGNITION AFTER MAJOR EPIDEMIOLOGIC TRANSITIONS - PROJECT SUMMARY/ABSTRACT STROKE MORTALITY HAS ALWAYS BEEN HIGHER FOR BLACK AMERICANS AND FOR THOSE LIVING IN THE AMERICAN SOUTHEAST, AKA THE STROKE BELT. THE REGARDS STUDY HAS BEEN EXAMINING RACIAL AND GEOGRAPHIC DIFFERENCES IN STROKE INCIDENCE AND COGNITIVE FUNCTION (INCLUDING COGNITIVE IMPAIRMENT, COGNITIVE DECLINE AND DEMENTIA) SINCE 2003. THIS COHORT OF 30,239 PEOPLE FROM ACROSS THE LOWER 48 UNITED STATES HAS BEEN ACTIVE FOR MORE THAN 20 YEARS WITH A 97% ANNUAL RETENTION RATE AND HAS GENERATED >700 PUBLICATIONS CREATING A TRULY UNIQUE SCIENTIFIC RESOURCE. LEVERAGING THE RICH, EXPANSIVE DATA COLLECTED BY REGARDS WILL BE CRITICAL TO UNDERSTAND MAJOR SOCIETAL CHANGES AND EPIDEMIOLOGIC TRANSITIONS INCLUDING: RISE IN OBESITY, COVID-19, AND WIDENING DISPARITIES DUE TO SOCIAL STRUCTURES. EVEN BEFORE THE COVID-19 PANDEMIC, AMERICA EXPERIENCED AN INFLECTION POINT WHEN THE LONG-PERSISTING IMPROVEMENT IN LIFE EXPECTANCY STAGNATED AND BEGAN REVERSING. LIFE EXPECTANCY HAS BEEN DECLINING SINCE 2014 IN PART DRIVEN BY INCREASED STROKE MORTALITY. THIS ALARMING TREND PLACES THE US AS DISCORDANT FROM MOST DEVELOPED NATIONS AS MOST HAVE CONTINUED TO EXPERIENCE INCREASING LIFE EXPECTANCY. THE REGARDS STUDY IS IDEAL FOR UNDERSTANDING HOW RACIAL DISPARITIES IN STROKE AND STROKE RISK FACTORS SUCH AS COGNITIVE DECLINE, BIOMARKERS OF BRAIN INJURY, SOCIAL DETERMINANTS OF HEALTH, DIET, AND BLOOD PRESSURE ARE CONTRIBUTING TO WIDER DECLINES IN LIFE EXPECTANCY IN THE US. THROUGH THIS NEW ROUND OF FUNDING, WE PROPOSE TO CREATE THE REGARDS-2 COHORT CONSISTING OF 8000 PARTICIPANTS FOLLOWED SINCE BASELINE (2003-07, BORN BETWEEN BORN 1908-1960) AND 12000 NEW YOUNGER PARTICIPANTS AGED 45-64 (BORN BETWEEN 1961 AND 1980). AIM 1 EXAMINES THE ROLE OF SECULAR CHANGES IN STROKE AND DEMENTIA RISK FACTORS COMPARING 15,326 INDIVIDUALS WHO WERE 45-64 IN 2003-2007 (MIDDLE AGED BABY BOOMER GENERATION) WITH 12,000 INDIVIDUALS WHO ARE 45-64 IN 2024-2027 (MIDDLE AGED GENERATION X). WE WILL FURTHER EXPLORE HOW CHANGES IN RISK FACTORS IN MIDDLE AGED ADULTS ARE DRIVING INCREASES IN STROKE INCIDENCE AND ALZHEIMER’S DISEASE AND RELATED DEMENTIA (ADRD). FOR AIM 2, WE WILL BUILD ON THE LARGE BIOMARKER REPOSITORY TO EXAMINE WHETHER EMERGING ADRD BLOOD-BASED BIOMARKERS ARE ASSOCIATED WITH INCIDENT ADRD AND STROKE. TO SUPPORT BI-DIRECTIONAL COMMUNICATION WITH THE REGARDS RESEARCH COMMUNITY AND THE REGARDS PARTICIPANT COMMUNITY, WE PROPOSE AN INFRASTRUCTURE AIM TO ESTABLISH A PARTICIPANT ADVISORY BOARD AND STRUCTURED MENTORING FOR SCIENTISTS, PARTICULARLY THOSE FROM BACKGROUNDS UNDER-REPRESENTED IN RESEARCH, INTERESTED IN WORKING IN HEALTH DISPARITIES IN STROKE AND DEMENTIA. THE REGARDS STUDY HAS BEEN AND WILL CONTINUE TO BE A STRONG PLATFORM FOR DEVELOPING FUTURE SCIENTISTS INTERESTED IN UNDERSTANDING AND ADDRESSING HEALTH DISPARITIES IN BLACK AND WHITE AMERICANS.

University Of Alabama At Birmingham

(1) TO SUPPORT EXTRAMURAL RESEARCH FUNDED BY THE NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS) INCLUDING: BASIC RESEARCH THAT EXPLORES THE FUNDAMENTAL STRUCTURE AND FUNCTION OF THE BRAIN AND THE NERVOUS SYSTEM, RESEARCH TO UNDERSTAND THE CAUSES AND ORIGINS OF PATHOLOGICAL CONDITIONS OF THE NERVOUS SYSTEM WITH THE GOAL OF PREVENTING THESE DISORDERS, RESEARCH ON THE NATURAL COURSE OF NEUROLOGICAL DISORDERS, IMPROVED METHODS OF DISEASE PREVENTION, NEW METHODS OF DIAGNOSIS AND TREATMENT, DRUG DEVELOPMENT, DEVELOPMENT OF NEURAL DEVICES, CLINICAL TRIALS, AND RESEARCH TRAINING IN BASIC, TRANSLATIONAL AND CLINICAL NEUROSCIENCE. THE INSTITUTE IS THE LARGEST FUNDER OF BASIC NEUROSCIENCE IN THE US AND SUPPORTS RESEARCH ON TOPICS INCLUDING BUT NOT LIMITED TO: DEVELOPMENT OF THE NERVOUS SYSTEM, INCLUDING NEUROGENESIS AND PROGENITOR CELL BIOLOGY, SIGNAL TRANSDUCTION IN DEVELOPMENT AND PLASTICITY, AND PROGRAMMED CELL DEATH, SYNAPSE FORMATION, FUNCTION, AND PLASTICITY, LEARNING AND MEMORY, CHANNELS, TRANSPORTERS, AND PUMPS, CIRCUIT FORMATION AND MODULATION, BEHAVIORAL AND COGNITIVE NEUROSCIENCE, SENSORIMOTOR LEARNING, INTEGRATION AND EXECUTIVE FUNCTION, NEUROENDOCRINE SYSTEMS, SLEEP AND CIRCADIAN RHYTHMS, AND SENSORY AND MOTOR SYSTEMS. IN ADDITION, THE INSTITUTE SUPPORTS BASIC, TRANSLATIONAL AND CLINICAL STUDIES ON A NUMBER OF DISORDERS OF THE NERVOUS SYSTEM INCLUDING (BUT NOT LIMITED TO): STROKE, TRAUMATIC INJURY TO THE BRAIN, SPINAL CORD AND PERIPHERAL NERVOUS SYSTEM, NEURODEGENERATIVE DISORDERS, MOVEMENT DISORDERS, BRAIN TUMORS, CONVULSIVE DISORDERS, INFECTIOUS DISORDERS OF THE BRAIN AND NERVOUS SYSTEM, IMMUNE DISORDERS OF THE BRAIN AND NERVOUS SYSTEM, INCLUDING MULTIPLE SCLEROSIS, DISORDERS RELATED TO SLEEP, AND PAIN. PROGRAMMATIC AREAS, WHICH ARE PRIMARILY SUPPORTED BY THE DIVISION OF NEUROSCIENCE, ARE ALSO SUPPORTED BY THE DIVISION OF EXTRAMURAL ACTIVITIES, THE DIVISION OF TRANSLATIONAL RESEARCH, THE DIVISION OF CLINICAL RESEARCH, THE OFFICE OF TRAINING AND WORKFORCE DEVELOPMENT, THE OFFICE OF PROGRAMS TO ENHANCE NEUROSCIENCE WORKFORCE DEVELOPMENT, AND THE OFFICE OF INTERNATIONAL ACTIVITIES. (2) TO EXPAND AND IMPROVE THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. TO UTILIZE THE SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM, TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH AND DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders

National Institute of Neurological Disorders and Stroke (NNDS) [HHS - NIH]

Birmingham, Alabama 35294 United States

Single Zip Code

Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional) (PAR-22-093)

Amendment Since initial award the total obligations have increased 7% from $16,244,011 to $17,452,175.