RF1AG088719

PARENT-CHILD TRANSMISSION OF TRAUMA IN A LONGITUDINAL COHORT: IMPACT ON AGING-RELATED MENTAL AND PHYSICAL HEALTH WELL-BEING - WE PROPOSE TO CONDUCT A 4TH WAVE OF DATA COLLECTION ON OUR LONGITUDINAL COHORT OF CHILDREN OF 9/11 DIRECTLY-EXPOSED PARENTS (WTC EVACUEES, GROUND ZERO AREA RESIDENTS AND FIRST RESPONDERS). WHILE THE ATTACK ON 9/11 WAS A TRAGEDY ALMOST BEYOND OUR CAPACITY TO ABSORB, THE LONG-TERM, ONGOING MENTAL AND PHYSICAL EFFECTS ON THOSE PRESENT -- AND THEIR FAMILIES – REMAIN, AT LEAST FOR MANY, UNABATED. SOON AFTER 9/11, OUR TEAM RECRUITED WHAT BECAME A LONGITUDINAL COHORT STUDY OF CHILDREN (CURRENTLY AGES 23-42) AND THEIR PARENTS (CURRENTLY AGES 42-88) WHO HAD EXPERIENCED DIRECT EXPOSURE TO THE WORLD TRADE CENTER (WTC) ATTACK, ALONG WITH COMMUNITY CONTROLS. INDIRECTLY EXPOSED CHILDREN CAME TO BE KNOWN AS THOSE EXPERIENCING “TAKE-HOME” EXPOSURE, BEING NOT DIRECTLY EXPOSED THEMSELVES. HAVING LEARNED THROUGH FOLLOW-UP ASSESSMENTS OF THE CRITICAL ROLE DISASTER-EXPERIENCED FAMILY MEMBERS HAVE ON THEIR CHILDREN’S WELL-BEING, AND THE CHILD’S RECIPROCAL ROLE ON THE EXPOSED ADULTS’ WELL-BEING, WE WILL FOCUS THIS FOURTH WAVE ON UNDERSTANDING THE ROLE OF AGING ON THE INTERGENERATIONAL IMPACT OF DISASTER AND ADVERSE EXPERIENCES AND THE ASSOCIATED OUTCOMES OF INTEREST, INCLUDING PSYCHOPATHOLOGY, PHYSICAL AND COGNITIVE WELL-BEING, COMORBIDITIES, AND MITOCHONDRIAL COPY NUMBER AS AN ADVERSITY-RELATED BIOMARKER OF OXIDATIVE STRESS. AS THE OFFSPRING COHORT REACHES MID-LIFE AND THE PARENTS, OLDER ADULTHOOD, THIS STUDY, UTILIZING FOUR WAVES OF DATA, IS EXPECTED TO YIELD IMPORTANT INSIGHTS INTO THE LONG-TERM IMPACT OF ADVERSE EXPERIENCES, THEIR INTERGENERATIONAL IMPACT, AND INFLUENCE ON AGING PROCESSES. THE 9/11-EXPOSED PARENTS AND THEIR INDIRECTLY EXPOSED CHILDREN HAVE BEEN COMPREHENSIVELY ASSESSED THROUGH IN-HOME INTERVIEWS OVER THREE WAVES OF DATA COLLECTION AND THE STUDY HAS AMASSED A WEALTH OF DATA ON LONG-TERM PSYCHIATRIC-PHYSICAL SEQUALAE TO MASS DISASTER EXPOSURE. THESE DATA HAVE PROVEN SIGNIFICANT, NOT ONLY IN UNDERSTANDING THE INDIRECTLY EXPOSED CHILD, BUT ALSO THE CONSEQUENCES TO THE EXPOSED PARENT. DATA FROM THIS LONGITUDINAL COHORT STRONGLY INDICATE THE NEED TO ASSESS BOTH INDIVIDUALS (PARENT AND CHILD) FROM A FAMILY PERSPECTIVE. WE APPRECIATE THAT THIS IS A TIMELY ISSUE, AS PARENTS AGE AND DISPROPORTIONATELY BECOME ILL AND MAY EXPERIENCE PREMATURE MORTALITY. WE PROPOSE, THEREFORE, TO FOCUS ON THE FAMILY UNIT FOR THE PURPOSE OF UNDERSTANDING THE COMPLEX, LONG-TERM IMPACT THAT PARENTAL DIRECT EXPOSURE HAS ON THE HEALTH AND WELL-BEING OF THEIR CHILDREN AND ON THE DIRECTLY EXPOSED PARENTS THEMSELVES. THIS FAMILY AGING STUDY WILL ALLOW THE FOURTH WAVE OF DATA COLLECTION TO EXAMINE TRAJECTORIES OF AGING-RELATED MEDICAL AND MENTAL WELL-BEING INCLUDING COGNITION, COMORBIDITIES, AND MITOCHONDRIAL COPY NUMBER, AS WELL AS EXAMINATION OF INTERGENERATIONAL EFFECTS. THIS COMPREHENSIVE APPROACH WILL IMPROVE UNDERSTANDING OF THE COMPLEX INTERACTIONS OF EMOTIONAL AND TOXIC 9/11 EXPOSURE THAT HAS IMPACTED BOTH THE MENTAL AND PHYSICAL REALMS AND CONTRIBUTED TO COMPLEX COMORBIDITIES AS EACH GROUP AGES. IT IS ANTICIPATED THAT THIS FAMILY AGING STUDY WILL CONTINUE AS A LONGITUDINAL INVESTIGATION OF ADVERSE EXPERIENCES, AND THEIR INTERGENERATIONAL IMPACT ON AGING PROCESSES.

Research Foundation For Mental Hygiene

TO ENCOURAGE BIOMEDICAL, SOCIAL, AND BEHAVIORAL RESEARCH AND RESEARCH TRAINING DIRECTED TOWARD GREATER UNDERSTANDING OF THE AGING PROCESS AND THE DISEASES, SPECIAL PROBLEMS, AND NEEDS OF PEOPLE AS THEY AGE. THE NATIONAL INSTITUTE ON AGING HAS ESTABLISHED PROGRAMS TO PURSUE THESE GOALS. THE DIVISION OF AGING BIOLOGY EMPHASIZES UNDERSTANDING THE BASIC BIOLOGICAL PROCESSES OF AGING. THE DIVISION OF GERIATRICS AND CLINICAL GERONTOLOGY SUPPORTS RESEARCH TO IMPROVE THE ABILITIES OF HEALTH CARE PRACTITIONERS TO RESPOND TO THE DISEASES AND OTHER CLINICAL PROBLEMS OF OLDER PEOPLE. THE DIVISION OF BEHAVIORAL AND SOCIAL RESEARCH SUPPORTS RESEARCH THAT WILL LEAD TO GREATER UNDERSTANDING OF THE SOCIAL, CULTURAL, ECONOMIC AND PSYCHOLOGICAL FACTORS THAT AFFECT BOTH THE PROCESS OF GROWING OLD AND THE PLACE OF OLDER PEOPLE IN SOCIETY. THE DIVISION OF NEUROSCIENCE FOSTERS RESEARCH CONCERNED WITH THE AGE-RELATED CHANGES IN THE NERVOUS SYSTEM AS WELL AS THE RELATED SENSORY, PERCEPTUAL, AND COGNITIVE PROCESSES ASSOCIATED WITH AGING AND HAS A SPECIAL EMPHASIS ON ALZHEIMER'S DISEASE. SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM: TO EXPAND AND IMPROVE THE SBIR PROGRAM, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, TO INCREASE SMALL BUSINESS PARTICIPATION IN FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION. SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAM: TO STIMULATE AND FOSTER SCIENTIFIC AND TECHNOLOGICAL INNOVATION THROUGH COOPERATIVE RESEARCH DEVELOPMENT CARRIED OUT BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO FOSTER TECHNOLOGY TRANSFER BETWEEN SMALL BUSINESS CONCERNS AND RESEARCH INSTITUTIONS, TO INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL RESEARCH AND DEVELOPMENT, AND TO FOSTER AND ENCOURAGE PARTICIPATION OF SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESS CONCERNS AND WOMEN-OWNED SMALL BUSINESS CONCERNS IN TECHNOLOGICAL INNOVATION.

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

New York United States

State-Wide

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) (PA-20-185)