RF1AG059651

PROMIS PROFILE MEASURES FOR OLDER ADULTS WITH COGNITIVE IMPAIRMENT-DEVELOPING VERSIONS FOR OLDER ADULTS WITH COGNITIVE IMPAIRMENT AND FOR PROXY COMPLETION - PROJECT SUMMARY THE NATIONAL INSTITUTES OF HEALTH (NIH) PATIENT-REPORTED OUTCOMES MEASUREMENT INFORMATION SYSTEM (PROMIS®) WAS DEVELOPED TO PROVIDE PRECISE AND VALID MEASURES OF PATIENT-REPORTED OUTCOMES, ESTABLISH A COMMON METRIC ACROSS CHRONIC HEALTH CONDITIONS, AND ENABLE COMPUTERIZED ADAPTIVE TESTING. MOST PATIENT-REPORTED MEASURES INCLUDING PROMIS MEASURES WERE NOT WIDELY TESTED IN THE OLDER ADULT POPULATION NOR AMONG THOSE WITH MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD). OUR PREVIOUS STUDY EXAMINED THE RELIABILITY AND VALIDITY OF THE PROMIS PROFILE MEASURES IN OLDER ADULTS, IDENTIFIED THRESHOLDS WHERE COGNITIVE IMPAIRMENT INVALIDATES THE USE OF THESE MEASURES, AND UNCOVERED PROBLEMATIC ITEMS IN THIS POPULATION. THIS RENEWAL EXTENDS OUR PREVIOUS WORK TO 1) DEVELOP AND VALIDATE A MODIFIED VERSION OF THE PROMIS PROFILE MEASURES SUITABLE FOR OLDER ADULTS WITH COGNITIVE IMPAIRMENT (OACI) AND 2) DEVELOP ADULT PROXY MEASURES FOR PATIENTS UNABLE TO RESPOND RELIABLY (EVEN WITH MODIFICATION FOR COGNITIVE IMPAIRMENT; PROXY-OACI).COGNITIVE INTERVIEWS WITH 20 PATIENTS WITH LOW COGNITION (MONTREAL COGNITIVE ASSESSMENT ≤25) AND 20 PROXIES ARE USED TO ASSESS THESE NEW VERSIONS. VALIDATION TESTING WILL BE PERFORMED TO SHOW 1) THE NEW PROMIS PROFILE-OACI IS RELIABLE AT A LOWER MOCA/MMSE SCORE THAN THE ORIGINAL VERSION, AND 2) RELIABILITY OF THE NEW PROMIS PROFILE-PROXY OACI. THE NEW MEASURES WILL BE TESTED IN 250 PATIENTS AND 200 PROXIES ENROLLED FROM OUTPATIENT PRACTICES WITH A RANGE OF COGNITIVE IMPAIRMENT FROM MCI TO ADRD AND FURTHER VALIDATED AND LINKED TO PROMIS SCALE METRICS USING A SAMPLE OF 500 ADULTS FROM AN INTERNET PANEL OF PATIENTS AGED 65+. SCALE RELIABILITY AND ITEM FUNCTIONING WILL BE ASSESSED BY INVESTIGATING DIFFERENTIAL ITEM FUNCTIONING ON THE NEW PROMIS PROFILES (USING ITEM-RESPONSE THEORY MODELING). VALIDITY WILL BE ASSESSED BY EXAMINING THE CONSISTENCY OF RELATIONSHIPS BETWEEN PROMIS PROFILES AND OTHER VARIABLES (E.G., SELF AND PROXY REPORTS ON SIMILAR MEASURES AND MEASURES OF OBSERVABLE PERFORMANCE) CROSS- SECTIONALLY FOR CONCURRENT VALIDITY. THIS STUDY WILL RESULT IN IMPROVED PROMIS PROFILE MEASURES OF DISABILITY, MENTAL HEALTH, AND SOCIAL ENGAGEMENT, WITH GREATER RELIABILITY AND VALIDITY FOR OLDER ADULTS WITH COGNITIVE IMPAIRMENT.

University Of Maryland, Baltimore

<P>THE GOALS ARE:</P><UL><LI>TO FOSTER FUNDAMENTAL CREATIVE DISCOVERIES, INNOVATIVE RESEARCH STRATEGIES, AND THEIR APPLICATIONS AS A BASIS FOR ULTIMATELY PROTECTING AND IMPROVING HEALTH;</LI><LI>TO DEVELOP, MAINTAIN, AND RENEW SCIENTIFIC HUMAN AND PHYSICAL RESOURCES THAT WILL ENSURE THE NATION'S CAPABILITY TO PREVENT DISEASE;</LI><LI>TO EXPAND THE KNOWLEDGE BASE IN MEDICAL AND ASSOCIATED SCIENCES IN ORDER TO ENHANCE THE NATION'S ECONOMIC WELL-BEING AND ENSURE A CONTINUED HIGH RETURN ON THE PUBLIC INVESTMENT IN RESEARCH; AND</LI><LI>TO EXEMPLIFY AND PROMOTE THE HIGHEST LEVEL OF SCIENTIFIC INTEGRITY, PUBLIC ACCOUNTABILITY, AND SOCIAL RESPONSIBILITY IN THE CONDUCT OF SCIENCE.</LI></UL><P>IN REALIZING THESE GOALS, THE NIH PROVIDES LEADERSHIP AND DIRECTION TO PROGRAMS DESIGNED TO IMPROVE THE HEALTH OF THE NATION BY CONDUCTING AND SUPPORTING RESEARCH:</P><UL><LI>IN THE CAUSES, DIAGNOSIS, PREVENTION, AND CURE OF HUMAN DISEASES;</LI><LI>IN THE PROCESSES OF HUMAN GROWTH AND DEVELOPMENT;</LI><LI>IN THE BIOLOGICAL EFFECTS OF ENVIRONMENTAL CONTAMINANTS;</LI><LI>IN THE UNDERSTANDING OF MENTAL, ADDICTIVE AND PHYSICAL DISORDERS; AND</LI><LI>IN DIRECTING PROGRAMS FOR THE COLLECTION, DISSEMINATION, AND EXCHANGE OF INFORMATION IN MEDICINE AND HEALTH, INCLUDING THE DEVELOPMENT AND SUPPORT OF MEDICAL LIBRARIES AND THE TRAINING OF MEDICAL LIBRARIANS AND OTHER HEALTH INFORMATION SPECIALISTS.</LI></UL>

93.866 - Aging Research

National Institute on Aging (NIA) [HHS - NIH]

Baltimore, Maryland 21201 United States

Single Zip Code

NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) (PA-25-301)