R61MH135106
Project Grant
Overview
Grant Description
Synchronized neuronal and peripheral biomarker recordings in freely moving humans - project summary/abstract recent technological advancements have allowed for single-neuron and intracranial electroencephalographic (IEEG) recordings in freely moving humans. However, these implanted neural recording devices have not been integrated with non-invasive peripheral biochemical recordings. The emergence of an experimental platform combining mobile deep brain recordings with wearable biochemical and biophysical sensors for use in real-world settings is unprecedented.
The proposed project will develop a novel platform that enables simultaneous single-neuron or IEEG, biochemical (cortisol, epinephrine), and biophysical (heart rate, skin conductance, and body and eye movements) activity to be recorded in freely moving human participants. As proof-of-concept, we will use this platform to investigate the neural and peripheral biomarker mechanisms underlying approach-avoidance behaviors during spatial navigation.
Through an interdisciplinary collaboration between UCLA, Stanford University, and the Veteran’s Administration Greater Los Angeles Healthcare System (VAGLAHS), the program will have access to human participants whom will have implanted electrodes within prefrontal cortex, amygdala, hippocampus, or nucleus accumbens regions. The proposed project outcomes will empower future studies and other researchers to investigate, for the first-time, deep brain and peripheral biomarker mechanisms underlying freely moving human behavior in naturalistic and ecologically valid environments.
The proposed project will develop a novel platform that enables simultaneous single-neuron or IEEG, biochemical (cortisol, epinephrine), and biophysical (heart rate, skin conductance, and body and eye movements) activity to be recorded in freely moving human participants. As proof-of-concept, we will use this platform to investigate the neural and peripheral biomarker mechanisms underlying approach-avoidance behaviors during spatial navigation.
Through an interdisciplinary collaboration between UCLA, Stanford University, and the Veteran’s Administration Greater Los Angeles Healthcare System (VAGLAHS), the program will have access to human participants whom will have implanted electrodes within prefrontal cortex, amygdala, hippocampus, or nucleus accumbens regions. The proposed project outcomes will empower future studies and other researchers to investigate, for the first-time, deep brain and peripheral biomarker mechanisms underlying freely moving human behavior in naturalistic and ecologically valid environments.
Funding Goals
NOT APPLICABLE
Grant Program (CFDA)
Awarding / Funding Agency
Place of Performance
Los Angeles,
California
900958353
United States
Geographic Scope
Single Zip Code
Related Opportunity
Analysis Notes
Amendment Since initial award the End Date has been shortened from 01/31/27 to 03/31/25 and the total obligations have increased 177% from $1,129,992 to $3,124,727.
Los Angeles University Of California was awarded
Integrated Neural Peripheral Biomarker Recordings Human Behavior Study
Project Grant R61MH135106
worth $3,124,727
from the National Institute of Mental Health in February 2024 with work to be completed primarily in Los Angeles California United States.
The grant
has a duration of 1 year 1 months and
was awarded through assistance program 93.242 Mental Health Research Grants.
The Project Grant was awarded through grant opportunity BRAIN Initiative: Brain Behavior Quantification and Synchronization (R61/R33 Clinical Trial Optional).
Status
(Complete)
Last Modified 5/21/26
Period of Performance
2/21/24
Start Date
3/31/25
End Date
Funding Split
$3.1M
Federal Obligation
$0.0
Non-Federal Obligation
$3.1M
Total Obligated
Activity Timeline
Transaction History
Modifications to R61MH135106
Additional Detail
Award ID FAIN
R61MH135106
SAI Number
R61MH135106-3906091387
Award ID URI
SAI UNAVAILABLE
Awardee Classifications
Public/State Controlled Institution Of Higher Education
Awarding Office
75N700 NIH National Institute of Mental Health
Funding Office
75N700 NIH National Institute of Mental Health
Awardee UEI
RN64EPNH8JC6
Awardee CAGE
4B557
Performance District
CA-36
Senators
Dianne Feinstein
Alejandro Padilla
Alejandro Padilla
Modified: 5/21/26